Current Views on Knee Osteoarthritis: 2nd Edition

Dear Colleagues,

The first volume of the Special Issue about knee osteoarthritis (OA) (“Knee Osteoarthritis – How Close are We to Disease Modifying Treatment?”) was a successful initiative. (https://www.mdpi.com/topics/osteoarthritis)

OA is a leading cause of disability worldwide and knee OA is among the most common disease localizations. There is evidence about existence of different phenotypes of knee OA. However, personalized approach to these patients is insufficiently applied. Moreover, there is no approved disease-modifying drug for the treatment of OA. Therapeutic approaches directed towards different underlying pathogenic processes in knee OA or administration of a drug combination may slow the disease progression. In a proportion of cases, knee OA is associated with obesity and metabolic syndrome. Increased risk of OA in obese patients was suggested to be not only a consequence of mechanical overload but also related to the effects of adipokines. Obesity-associated knee OA is suggested to represent a distinct phenotype—the so-called metabolic knee OA. A new personalized approach towards patients with knee OA, which aims to retard disease progression, i.e., to possess disease-modifying potential, is more than welcome.

Thus, this special issue aims to summarize the available knowledge on this topic. We invite you to share your research and opinion about current views on pathogenesis and treatment of knee OA.

Dr. Sevdalina Lambova
Guest Editor

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