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Life
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Latest Advances in Dermatology: From Molecular Insights into Clinical Applications
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Latest Advances in Dermatology: From Molecular Insights into Clinical Applications

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (28 February 2025) | Viewed by 4198

Special Issue Editors

Dr. Emilio García Mouronte

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Guest Editor
Dermatology Department, University Hospital Ramon y Cajal, Madrid, Spain
Interests: skin cancer; photodynamic therapy; non-invasive imaging techniques; dermoscopy; confocal microscopy; laser; inflammatory disorders
Dr. Alfonso Perez-Gonzalez

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Guest Editor
Dermatology Department, University Hospital Ramon y Cajal, Madrid, Spain
Interests: photodynamic therapy; photobiomodulation; inflammatory dermatoses; autoinflammatory and autoimmune disorders

Special Issue Information

Dear Colleagues,

Precise diagnostic techniques and targeted therapies are the cornerstones of personalized medicine. In recent decades, substantial progress has been made in elucidating the molecular pathogenic mechanisms underlying numerous skin disorders, including inflammatory dermatoses and skin cancers.

The advent of innovative treatments, such as immunotherapy, biologic drugs targeting key cytokines in the pathophysiology of multiple inflammatory dermatoses, and JAK (tyrosine kinases inhibitors), has significantly revolutionized dermatology, improving the prognosis and management of previously challenging conditions, such as psoriasis, atopic dermatitis, alopecia areata, and metastatic melanoma.

Moreover, ongoing efforts to identify new biomarkers hold promise for predicting response and tolerability to specific therapies, thus minimizing side effects, improving the selection of patients eligible for therapies, and avoiding unnecessary treatments.

This Special Issue of Life invites original research articles, brief reports, and review articles that explore the latest advancements in the molecular diagnosis and targeted therapies of skin diseases. We aim to highlight cutting-edge research that bridges molecular insights and clinical applications, offering novel perspectives and therapeutic approaches to improve patient outcomes.

Dr. Emilio García Mouronte
Dr. Alfonso Perez-Gonzalez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dermatology
  • personalized medicine
  • molecular diagnostic techniques
  • targeted therapies
  • skin cancer
  • inflammatory skin diseases

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

13 pages, 2020 KiB  
Article
Efficacy of Fractional CO2 Laser Therapy in Improving Symptoms and Quality of Life in Women with Refractory Vulvar Lichen Sclerosus: A Prospective Observational Study
by Ana Gil-Villalba, Ángela Ayén-Rodríguez, María José Naranjo-Díaz, Laura Linares-González and Ricardo Ruiz-Villaverde
Life 2024, 14(12), 1678; https://doi.org/10.3390/life14121678 - 18 Dec 2024
Viewed by 1785
Abstract
Lichen sclerosus (LS) is a chronic inflammatory condition predominantly affecting the anogenital region of postmenopausal women. It is associated with considerable aesthetic and functional impairments and an increased risk of squamous cell carcinoma. While high-potency topical corticosteroids remain the cornerstone of treatment, therapeutic [...] Read more.
Lichen sclerosus (LS) is a chronic inflammatory condition predominantly affecting the anogenital region of postmenopausal women. It is associated with considerable aesthetic and functional impairments and an increased risk of squamous cell carcinoma. While high-potency topical corticosteroids remain the cornerstone of treatment, therapeutic options for patients with refractory LS are scarce. Fractional CO2 laser therapy has emerged as a potential second-line intervention aiming to mitigate symptoms and improve quality of life. This prospective observational study investigated the short-term efficacy and safety of fractional CO2 laser therapy in 75 women with refractory LS who underwent four treatment sessions between January 2022 and February 2024. Sixty-nine patients completed the protocol, demonstrating significant reductions in key symptoms, including pruritus (VAS score from 7.53 ± 3.02 to 4.08 ± 3.07), pain (5.83 ± 3.84 to 2.42 ± 2.85), and dyspareunia (8.26 ± 2.82 to 6.34 ± 3.30). Quality of life, sexual function, and psychological well-being also improved, as evidenced by reductions in Dermatology Life Quality Index (DLQI) scores (10.72 ± 7.25 to 5.94 ± 5.16), enhancements in sexual function (FSFI scores from 10.48 ± 8.46 to 15.52 ± 9.59), and decreased depression severity (BDI scores from 16.66 ± 12.64 to 5.94 ± 5.16). Importantly, no adverse effects were reported during the study period. Although these findings highlight the potential of fractional CO2 laser therapy as a safe and effective adjunct for refractory LS, it is essential to acknowledge the study’s limitations, particularly the relatively short follow-up period. Longer-term studies are warranted to confirm sustained benefits and to evaluate the broader applicability of this approach. Full article
(This article belongs to the Special Issue Latest Advances in Dermatology: From Molecular Insights into Clinical Applications)
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8 pages, 1614 KiB  
Article
The Prevalence of Demodex spp. Infestation in Dermatological Patients in Northern Poland
by Katarzyna Rychlik, Julia Sternicka, Monika Zabłotna, Roman J. Nowicki, Leszek Bieniaszewski and Dorota Purzycka-Bohdan
Life 2024, 14(9), 1196; https://doi.org/10.3390/life14091196 - 21 Sep 2024
Cited by 1 | Viewed by 1829
Abstract
The presence of Demodex spp. mites on the skin is a common phenomenon in the human population. In most people, it is an asymptomatic infestation, but in some patients, it can contribute to the occurrence of diseases such as demodicosis, rosacea, or blepharitis, [...] Read more.
The presence of Demodex spp. mites on the skin is a common phenomenon in the human population. In most people, it is an asymptomatic infestation, but in some patients, it can contribute to the occurrence of diseases such as demodicosis, rosacea, or blepharitis, as well as non-specific symptoms. In this study, the results of tests assessing the presence of Demodex spp. by direct microscopic examination (DME) in 2508 patients from northern Poland with the suspicion of demodicosis were retrospectively analyzed. A total of 3684 tests were performed. Among them, only 1585 (43.02%) revealed the presence of Demodex spp., while 2099 (56.98%) were negative. It was shown that in the analyzed population of patients with clinical suspicion of demodicosis, the degree of confirmation of the presence of Demodex spp. positively correlated with the patient’s age (p = 0.001) and the mite was mainly found on the edges of eyelids and on the facial skin. Additionally, in men, the presence of Demodex was more often confirmed than in women (p = 0.004). In conclusion, the proper diagnosis of demodicosis still constitutes an important clinical problem due to the non-specificity of symptoms and the low confirmation of clinical suspicions of infestation by DME, especially in lower age groups. Full article
(This article belongs to the Special Issue Latest Advances in Dermatology: From Molecular Insights into Clinical Applications)
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