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Life, Volume 14, Issue 12

2024 December - 184 articles

Cover Story: This article reviews the mechanisms and potential therapeutic implications of aquaporins (AQPs) in critical illnesses. AQPs are known to facilitate water transport and maintain cellular homeostasis, yet their specific involvement in conditions like sepsis, acute respiratory distress syndrome (ARDS), acute kidney injury (AKI), and acute brain injury (ABI) is less understood. We searched the existing literature and highlighted how the dysregulation of AQPs contributes to fluid imbalances and organ dysfunction in critically ill patients. It seems that altered AQP expression correlates with disease severity and outcomes, suggesting that AQPs could serve as biomarkers and therapeutic targets. This review enhances our understanding of AQPs' multifaceted roles in critical care. View this paper
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Articles (184)

  • Article
  • Open Access
3 Citations
2,242 Views
11 Pages

Reliability and Sensitivity of Enode/Vmaxpro Sensor for Muscle Power Assessment

  • Milan Marković,
  • Lazar Toskić,
  • Veroljub Stanković,
  • Radenko Arsenijević,
  • Nikola Aksović,
  • Bojan Bjelica,
  • Saša Bubanj and
  • Tatiana Dobrescu

23 December 2024

(1) Background: Regardless of the level of physical activity, performance monitoring is a valuable component of the training process. The aim of this research was to assess the reliability and sensitivity of parameter measurements using the Enode/Vma...

(This article belongs to the Section Physiology and Pathology)
  • Article
  • Open Access
3 Citations
1,861 Views
16 Pages

Identification of miRNAs Involved in Olfactory Regulation in Antennae of Beet Webworm, Loxostege sticticalis (Lepidoptera: Pyralidae)

  • Yu Zhang,
  • Yanyan Li,
  • Haibin Han,
  • Xiaoling Wang,
  • Shujing Gao,
  • Qing Zhao,
  • Halima Bieerdebieke,
  • Linbo Xu,
  • Qicong Zang and
  • Kejian Lin
  • + 2 authors

23 December 2024

The beet webworm, Loxostege sticticalis, is a typical migratory pest. Although miRNAs participate in many physiological functions, little is known about the functions of miRNAs in olfactory regulation. In this study, 1120 (869 known and 251 novel) mi...

(This article belongs to the Special Issue Recent Advances in Chemosensory-Based Behaviorally, Physiologically, and Molecularly Manipulated Technology of Pest Insects)
  • Article
  • Open Access
7 Citations
2,723 Views
12 Pages

23 December 2024

This study aimed to evaluate the incidence of total knee arthroplasty (TKA), a marker of severe knee osteoarthritis (OA), among older females with concurrent knee OA and osteoporosis (OP) who were treated with denosumab or bisphosphonates. By analyzi...

(This article belongs to the Special Issue Current Views on Knee Osteoarthritis: 2nd Edition)
  • Article
  • Open Access
6 Citations
2,949 Views
13 Pages

Differential Gut Microbiome Profiles in Long-Distance Endurance Cyclists and Runners

  • Guy Shalmon,
  • Rawan Ibrahim,
  • Ifat Israel-Elgali,
  • Meitar Grad,
  • Rani Shlayem,
  • Guy Shapira,
  • Noam Shomron,
  • Ilan Youngster and
  • Mickey Scheinowitz

23 December 2024

We recently have shown that the gut microbiota composition in female and male runners positively correlates with sports, and female runners show similar gut microbiome diversity to male runners. However, gut microbiota composition has not yet been fu...

(This article belongs to the Section Microbiology)
  • Article
  • Open Access
16 Citations
6,638 Views
23 Pages

Comparative Analysis of Infusions and Ethanolic Extracts of Annona muricata Leaves from Colima, Mexico: Phytochemical Profile and Antioxidant Activity

  • Gustavo A. Hernandez-Fuentes,
  • Osiris G. Delgado-Enciso,
  • Edgar G. Larios-Cedeño,
  • Juan M. Sánchez-Galindo,
  • Silvia G. Ceballos-Magaña,
  • Kayim Pineda-Urbina,
  • Mario A. Alcalá-Pérez,
  • Nancy E. Magaña-Vergara,
  • Josuel Delgado-Enciso and
  • Ivan Delgado-Enciso
  • + 5 authors

23 December 2024

Background: Annona muricata L. (guanabana) leaves are rich in bioactive compounds with potential antioxidant properties. In the state of Colima, both ethanolic extracts and infusions are traditionally used in folk medicine to address various ailments...

(This article belongs to the Special Issue Plants as a Promising Biofactory for Bioactive Compounds: 2nd Edition)
  • Review
  • Open Access
3 Citations
7,336 Views
12 Pages

23 December 2024

The rise in liver disease incidence and prevalence has led to increasing morbidity and mortality worldwide. Persistent hepatic inflammation drives disease progression by increasing fibrosis, advancing to cirrhosis, and potentially developing into hep...

(This article belongs to the Section Pharmaceutical Science)
  • Systematic Review
  • Open Access
7 Citations
3,457 Views
17 Pages

22 December 2024

Transoral robotic surgery (TORS) for tongue base reduction (TBR) and/or epiglottic surgery is an effective treatment option for selected patients with moderate to severe obstructive sleep apnoea (OSA). This systematic review aims to provide an up-to-...

(This article belongs to the Special Issue Obstructive Sleep Apnea: Current Knowledge and Future Perspectives)
  • Review
  • Open Access
4 Citations
7,743 Views
11 Pages

The Role of Corticosteroids in Non-Bacterial and Secondary Encephalitis

  • Giusy Di Flumeri,
  • Luca Gregorio Giaccari,
  • Maria Caterina Pace,
  • Maria Beatrice Passavanti,
  • Vincenzo Pota,
  • Vincenzo Riccardi,
  • Simona Brunetti,
  • Pasquale Sansone,
  • Francesco Coppolino and
  • Caterina Aurilio

22 December 2024

Encephalitis affects 1.9 to 14.3 people per 100,000 each year, and the mortality rate varies but can be up to 40%. After the identification of a particular microorganism in a patient with encephalitis, appropriate antimicrobial therapy should be init...

(This article belongs to the Section Pharmaceutical Science)
  • Article
  • Open Access
5 Citations
7,029 Views
14 Pages

Long-Term Efficacy of Combined Focused and Radial Extracorporeal Shockwave Therapy for Gluteus Medius Tendon Pathology: A Pilot Study

  • Federica Fulceri,
  • Larisa Ryskalin,
  • Gabriele Morucci,
  • Francesco Busoni,
  • Paola Soldani and
  • Marco Gesi

21 December 2024

Background: Gluteus medius tendinopathy is amongst the most prevalent lower limb tendinopathies and is now recognized as the primary cause of insidious lateral hip pain. Typically affecting middle-aged women, this condition causes disability and redu...

(This article belongs to the Special Issue Feature Papers in Medical Research: 3rd Edition)
  • Article
  • Open Access
3 Citations
1,812 Views
17 Pages

Can Aluminum Affect Social Behavior and Cortisol Plasma Profile in the Neotropical Freshwater Teleost Astyanax lacustris (Teleostei: Characidae)?

  • Natália Pires Vieira Morais de Faria,
  • Bruno Cavalheiro Araújo,
  • Bianca Mayumi Silva Kida,
  • Raisa Pereira Abdalla,
  • Diego dos Santos Brito,
  • Renata Guimarães Moreira and
  • Renato Massaaki Honji

21 December 2024

Aluminum (Al) can cause endocrine disruption in aquatic animals, but assessments of animal social behavior in neotropical teleost fish species with importance for Brazilian aquaculture have still not been addressed so far, which can further complete...

(This article belongs to the Section Animal Science)
  • Article
  • Open Access
4 Citations
2,478 Views
16 Pages

21 December 2024

Background: Effective management of primary apical periodontitis depends on understanding the dynamic interactions within the root canal microbiome. This study aimed to investigate the effect of sequential antimicrobial phases on the root canal micro...

(This article belongs to the Section Microbiology)
  • Article
  • Open Access
1 Citations
2,305 Views
15 Pages

Gut Microbiota Regulates the Homeostasis of Dendritic Epidermal T Cells

  • Jinwoo Chung,
  • Joo-Chan Lee,
  • Hanna Oh,
  • Yesung Kim,
  • Suin Lim,
  • Chanu Lee,
  • Yoon-Gyu Shim,
  • Eun-Chong Bang and
  • Jea-Hyun Baek

21 December 2024

Dendritic epidermal T cells (DETCs) are a γδ T cell subset residing in the skin epidermis. Although they have been known for decades, the fate of DETCs has largely remained enigmatic. Recent studies have highlighted the relationship betwe...

(This article belongs to the Special Issue Microbiota in Health and Disease)
  • Article
  • Open Access
3 Citations
3,606 Views
22 Pages

Localization of Secondary Metabolites in Relict Gymnosperms of the Genus Sequoia In Vivo and in Cell Cultures In Vitro, and the Biological Activity of Their Extracts

  • Rima N. Kirakosyan,
  • Elena A. Kalasnikova,
  • Elizaveta A. Bolotina,
  • Abdulrahman Saleh,
  • Anastasiya A. Balakina and
  • Svetlana M. Zaytseva

20 December 2024

In order to scientifically search for new sources of secondary metabolites with valuable qualities for phytopharmacognosy, tasks requiring a step-by-step solution were set. The primary task is the development of technologies for obtaining in vitro hi...

(This article belongs to the Special Issue Plants as a Promising Biofactory for Bioactive Compounds: 2nd Edition)
  • Article
  • Open Access
1 Citations
5,201 Views
13 Pages

20 December 2024

Background: Postoperative nausea and vomiting (PONV) remains a frequent and uncomfortable complication in women undergoing robotic gynecological procedures. Despite the use of various preventive strategies, PONV continues to negatively impact recover...

(This article belongs to the Special Issue Current Approaches and Future Directions in the Treatment of Gynecologic Tumors: Molecular Biology, Diagnostic Advancements and Targeted Therapeutic Strategies)
  • Article
  • Open Access
6 Citations
6,525 Views
18 Pages

Metagenome Analysis Identified Novel Microbial Diversity of Sandy Soils Surrounded by Natural Lakes and Artificial Water Points in King Salman Bin Abdulaziz Royal Natural Reserve, Saudi Arabia

  • Yahya S. Al-Awthan,
  • Rashid Mir,
  • Fuad A. Alatawi,
  • Abdulaziz S. Alatawi,
  • Fahad M. Almutairi,
  • Tamer Khafaga,
  • Wael M. Shohdi,
  • Amal M. Fakhry and
  • Basmah M. Alharbi

20 December 2024

Background: Soil microbes play a vital role in the ecosystem as they are able to carry out a number of vital tasks. Additionally, metagenomic studies offer valuable insights into the composition and functional potential of soil microbial communities....

(This article belongs to the Special Issue Trends in Microbiology 2025)
  • Article
  • Open Access
4 Citations
2,488 Views
20 Pages

Genomic Characterization of Probiotic Purple Nonsulfur Bacteria Cereibacter sphaeroides Strains S3W10 and SS15: Implications for Enhanced Shrimp Aquaculture

  • Chollachai Klaysubun,
  • Nattarika Chaichana,
  • Sirikan Suwannasin,
  • Kamonnut Singkhamanan,
  • Thunchanok Yaikhan,
  • Duangporn Kantachote,
  • Rattanaruji Pomwised,
  • Monwadee Wonglapsuwan and
  • Komwit Surachat

20 December 2024

Cereibacter sphaeroides strains S3W10 and SS15, isolated from shrimp ponds, exhibit potential probiotic benefits for aquaculture. In this study, the genomic features of S3W10 and SS15 were thoroughly characterized to evaluate their probiotic properti...

(This article belongs to the Section Animal Science)
  • Article
  • Open Access
3 Citations
3,225 Views
19 Pages

20 December 2024

Oryza sativa (rice) is a major staple food targeted for increased production to achieve food security. However, increased production is threatened by several biotic and abiotic factors, of which bacterial blight disease caused by Xanthomonas oryzae p...

(This article belongs to the Special Issue Trends in Microbiology 2025)
  • Article
  • Open Access
6 Citations
2,700 Views
17 Pages

Identification of Potential Sepsis Therapeutic Drugs Using a Zebrafish Rapid Screening Approach

  • Mark Widder,
  • Chance Carbaugh,
  • William van der Schalie,
  • Ronald Miller,
  • Linda Brennan,
  • Ashley Moore,
  • Robert Campbell,
  • Kevin Akers,
  • Roseanne Ressner and
  • Charlotte Lanteri
  • + 4 authors

20 December 2024

In the military, combat wound infections can progress rapidly to life-threatening sepsis. The discovery of effective small-molecule drugs to prevent and/or treat sepsis is a priority. To identify potential sepsis drug candidates, we used an optimized...

(This article belongs to the Special Issue Current Advances in Diagnosis and Treatment of Sepsis)
  • Review
  • Open Access
17 Citations
10,239 Views
44 Pages

Exploring Aquaporins in Human Studies: Mechanisms and Therapeutic Potential in Critical Illness

  • Charikleia S. Vrettou,
  • Vasileios Issaris,
  • Stelios Kokkoris,
  • Georgios Poupouzas,
  • Chrysi Keskinidou,
  • Nikolaos S. Lotsios,
  • Anastasia Kotanidou,
  • Stylianos E. Orfanos,
  • Ioanna Dimopoulou and
  • Alice G. Vassiliou

20 December 2024

Aquaporins (AQPs) are membrane proteins facilitating water and other small solutes to be transported across cell membranes. They are crucial in maintaining cellular homeostasis by regulating water permeability in various tissues. Moreover, they regul...

(This article belongs to the Collection Feature Review Papers for Life)
  • Correction
  • Open Access
1 Citations
1,081 Views
2 Pages

Correction: Tognetti et al. Pattern Analysis of Benign and Malignant Atypical Melanocytic Skin Lesions of Palms and Soles: Variations of Dermoscopic Features According to Anatomic Site and Personal Experience. Life 2024, 14, 659

  • Linda Tognetti,
  • Alessandra Cartocci,
  • Elvira Moscarella,
  • Aimilios Lallas,
  • Emi Dika,
  • Maria Concetta Fargnoli,
  • Caterina Longo,
  • Gianluca Nazzaro,
  • John Paoli and
  • Pietro Rubegni
  • + 12 authors

20 December 2024

“Harald Kittler” was not included as an author in the original publication [...]

(This article belongs to the Section Medical Research)
  • Article
  • Open Access
4,035 Views
12 Pages

Identification of Novel Inhibitors of Starch Excess 4 (SEX4)

  • Damhee Lee,
  • Dongsun Lee,
  • Kyujeong Won,
  • Suhyun Kim and
  • Youngjun Kim

20 December 2024

This study identified several inhibitors of Starch Excess 4 (SEX4), an enzyme in plants’ starch decomposition. Our research aims to inhibit starch breakdown by SEX4 with its potential to significantly impact food security, leading to starch acc...

(This article belongs to the Section Biochemistry, Biophysics and Computational Biology)
  • Article
  • Open Access
11 Citations
3,494 Views
18 Pages

Quercetin Enhances 5-Fluorouracil-Driven Cytotoxicity Dose-Dependently in A375 Human Melanoma Cells

  • Andrea Roman,
  • Andreea Smeu,
  • Ana Lascu,
  • Cristina Adriana Dehelean,
  • Iasmina-Alexandra Predescu,
  • Andrei Motoc,
  • Claudia Borza,
  • George Andrei Draghici,
  • Cristina Maria Trandafirescu and
  • Simona Ardelean
  • + 1 author

19 December 2024

Cutaneous melanoma (CM) represents a severe skin cancer with a rising incidence at present and limited treatment options. 5-Fluorouracil (5-FU) is widely used, including for CM; however, the innate resistance of this cancer to conventional therapy re...

(This article belongs to the Special Issue Natural Bioactives: Exploring Their Therapeutic Potential)
  • Article
  • Open Access
4 Citations
4,048 Views
15 Pages

Comparative Biomechanical Analysis of Kirschner Wire Fixation in Dorsally Displaced Distal Radius Fractures

  • Awad Dmour,
  • Ștefan-Lucian Toma,
  • Alin-Marian Cazac,
  • Stefan Dragos Tirnovanu,
  • Nicoleta Dima,
  • Bianca-Ana Dmour,
  • Dragos Cristian Popescu and
  • Ovidiu Alexa

19 December 2024

Objective: This study aims to evaluate and compare the biomechanical performance of two Kirschner (K) wire configurations—the intra-focal and interfragmentary techniques—for the fixation of dorsally displaced distal radius fractures. The...

(This article belongs to the Section Medical Research)
  • Review
  • Open Access
2,183 Views
17 Pages

Stereotactic Body Therapy for Urologic Cancers—What the Urologist Needs to Know

  • Jasamine Coles-Black,
  • Adib Rahman,
  • Shankar Siva,
  • Joseph Ischia,
  • Marlon Perera,
  • Damien Bolton and
  • Nathan Lawrentschuk

19 December 2024

Background: stereotactic ablative body radiotherapy (SABR) is a disruptive radiation therapy technique which is increasingly used for the treatment of urologic cancers. The aim of this narrative review is to provide an overview on the current landsca...

(This article belongs to the Section Medical Research)
  • Article
  • Open Access
7 Citations
2,978 Views
13 Pages

Effect of Metformin on Meibomian Gland Epithelial Cells: Implications in Aging and Diabetic Dry Eye Disease

  • Leon Rescher,
  • Swati Singh,
  • Ingrid Zahn,
  • Friedrich Paulsen and
  • Martin Schicht

18 December 2024

Background: Metformin, a commonly prescribed medication for managing diabetes, has garnered increasing interest as a potential therapeutic option for combating cancer and aging. Methods: The current study investigated the effects of metformin treatme...

(This article belongs to the Special Issue Eye Diseases: Diagnosis and Treatment, 3rd Edition)
  • Article
  • Open Access
3 Citations
2,471 Views
10 Pages

Ureteral Closure Using Advanced Bipolar Vessel Sealing Devices During Laparoscopic Nephrectomy in Dogs and Cats: A Pilot Series of Clinical Cases

  • Przemysław Prządka,
  • Bartłomiej Liszka,
  • Kamil Suliga,
  • Agnieszka Antończyk,
  • Zdzisław Kiełbowicz,
  • Dominika Kubiak-Nowak,
  • Stanisław Dzimira,
  • Adam Skalski and
  • Ludwika Gąsior

18 December 2024

Recently, laparoscopic nephrectomy has become more popular in veterinary medicine. In the majority of these procedures, vascular sealing devices (VSDs) are used. These allow for the closure of renal vessels with advanced bipolar coagulation. However,...

(This article belongs to the Special Issue Veterinary Pathology and Veterinary Anatomy: 2nd Edition)
  • Article
  • Open Access
2 Citations
1,374 Views
13 Pages

Characterization of the PaHAK Gene and Its Expression During the In Vitro Seed Germination of Two Botanical Avocado Varieties Under Saline Stress

  • Essoh Aimé Cesaire Elekou,
  • Luis María Suárez-Rodríguez,
  • Mariela Gómez-Romero,
  • Jannette Sofia Bayuelo-Jiménez,
  • Andrés Belver,
  • Juan Carlos Díaz-Pérez and
  • Rodolfo López-Gómez

18 December 2024

Soil salinity is one of the main challenges that modern agriculture faces. Avocado, which is classified as a glycophyte, is very sensitive to salt stress. There are botanical varieties of avocado that differ in their salt tolerance. This study invest...

(This article belongs to the Special Issue Plant Biotic and Abiotic Stresses 2024)
  • Article
  • Open Access
2 Citations
2,813 Views
11 Pages

18 December 2024

Postoperative fluid overload is associated with increased mortality and morbidity in infants with congenital heart disease (CHD). Loop diuretics, such as furosemide, are commonly used to prevent fluid overload in the postoperative period. This study...

(This article belongs to the Special Issue Conservative Management of Chronic Disease)
  • Article
  • Open Access
8 Citations
7,665 Views
13 Pages

Efficacy of Fractional CO2 Laser Therapy in Improving Symptoms and Quality of Life in Women with Refractory Vulvar Lichen Sclerosus: A Prospective Observational Study

  • Ana Gil-Villalba,
  • Ángela Ayén-Rodríguez,
  • María José Naranjo-Díaz,
  • Laura Linares-González and
  • Ricardo Ruiz-Villaverde

18 December 2024

Lichen sclerosus (LS) is a chronic inflammatory condition predominantly affecting the anogenital region of postmenopausal women. It is associated with considerable aesthetic and functional impairments and an increased risk of squamous cell carcinoma....

(This article belongs to the Section Medical Research)
  • Article
  • Open Access
8 Citations
27,787 Views
13 Pages

Pilot Study on the Effects of a Cosmetic Serum Containing Niacinamide, Postbiotics and Peptides on Facial Skin in Healthy Participants: A Randomized Controlled Trial

  • Doris Rusic,
  • Magdalena Ivic,
  • Ana Slugan,
  • Dario Leskur,
  • Darko Modun,
  • Toni Durdov,
  • Dubravka Vukovic,
  • Josipa Bukic,
  • Josko Bozic and
  • Ana Seselja Perisin

18 December 2024

The literature describes niacinamide, but also postbiotics and peptides, as ingredients that improve skin barrier function, but also affect melanin and sebum levels in individuals. However, the combined effects of these ingredients in a single cosmet...

(This article belongs to the Section Physiology and Pathology)
  • Systematic Review
  • Open Access
1 Citations
6,831 Views
14 Pages

Effectiveness of Manual Bronchial Clearance Techniques in the Treatment of Bronchiolitis

  • Nathali Carvajal-Tello,
  • Alejandro Segura-Ordoñez,
  • Valeria Grisales-Jaramillo,
  • Laura Isabella Rayo-Salazar,
  • Katheryne Julieh Hernandez-Peñuela and
  • Jose Luis Estela-Zape

18 December 2024

Background: Bronchiolitis is a seasonal viral infection of the respiratory tract that causes numerous childhood hospitalizations annually. Treatments vary based on severity, with mild cases requiring fluids and moderate to severe cases involving hosp...

(This article belongs to the Section Medical Research)
  • Article
  • Open Access
4 Citations
2,399 Views
21 Pages

18 December 2024

The presence of bile acids in the cystic fibrosis patient’s lungs contributes to an increase in the inflammatory response, in the dominance of pathogens, as well as in the decline in lung function, increasing morbidity. The aim of this study is...

(This article belongs to the Section Microbiology)
  • Article
  • Open Access
2 Citations
2,429 Views
12 Pages

18 December 2024

Background: Despite extensive research on proteinuria’s impact on chronic kidney disease progression, there is no direct comparison of outcomes in biopsy-diagnosed glomerular disease (GD) patients with nephrotic syndrome (NS) or nephrotic range...

(This article belongs to the Special Issue Recent Insights in the Pathogenesis, Diagnosis, Prognosis and Treatment of Glomerular Disorders)
  • Article
  • Open Access
10 Citations
2,864 Views
12 Pages

Immunomodulatory Properties of Multi-Strain Postbiotics on Human CD14+ Monocytes

  • Kyle D. Roberts,
  • Sadia Ahmed,
  • Erin San Valentin,
  • Luca Di Martino,
  • Thomas S. McCormick and
  • Mahmoud A. Ghannoum

17 December 2024

The ability of probiotics, comprising live microbiota, to modulate the composition of intestinal microbiomes has been connected to modulation of the central nervous system (Gut–Brain axis), neuroendocrine system (Gut–Skin axis), and immun...

(This article belongs to the Section Microbiology)
  • Article
  • Open Access
4 Citations
1,814 Views
13 Pages

17 December 2024

Dexmedetomidine (DEX) is a selective alpha-2 adrenergic receptor agonist with sedative and anxiolytic properties. Increasing evidence reports that DEX has a neuroprotective effect. In this study, we investigated the potential effects of DEX on learni...

(This article belongs to the Special Issue Feature Paper in Physiology and Pathology: 2nd Edition)
  • Review
  • Open Access
4 Citations
3,443 Views
18 Pages

Exploring the Functionality of the Krüppel-like Factors in Kidney Development, Metabolism, and Diseases

  • Itzel S. Salmon-Cabrales,
  • David A. de la Garza-Kalife,
  • Gabriel García-González,
  • Ana E. Estrada-Rodríguez,
  • Marco Antonio Jiménez-Gutiérrez,
  • Michelle G. Santoyo-Suárez,
  • Oscar Rodríguez-Núñez,
  • Elsa N. Garza-Treviño,
  • Diego F. Benítez-Chao and
  • Jose Francisco Islas
  • + 1 author

17 December 2024

The kidneys contribute to the overall health of an organism by maintaining systemic homeostasis. This process involves various biological mechanisms, in which the Krüppel-like factors (KLFs), a family of transcription factors, are essential for...

(This article belongs to the Special Issue Feature Paper in Physiology and Pathology: 2nd Edition)
  • Article
  • Open Access
3 Citations
3,129 Views
9 Pages

Immunohistochemical Evaluation of Basal and Luminal Markers in Bladder Cancer: A Study from a Single Institution

  • Anh Toan Do,
  • Quoc Thang Pham,
  • Ngoc Minh Tam Nguyen,
  • Phuc Nguyen Nguyen,
  • Thi Thanh Tam Bui and
  • Quoc Dat Ngo

17 December 2024

Background: Bladder cancer (BC) presents significant molecular diversity, which affects both prognosis and treatment results. Immunohistochemistry (IHC) facilitates the identification of molecular subtypes and their relationships with clinicopatholog...

(This article belongs to the Section Physiology and Pathology)
  • Article
  • Open Access
2 Citations
4,854 Views
15 Pages

Boswellia serrate Gum Resin Mitigates Renal Toxicity: Role of TNF-α, Interleukins, TGF-β, and Lipid Peroxidation

  • Heba M. Eltahir,
  • Abdel-Gawad S. Shalkami,
  • Ahmed M. Shehata,
  • Mohannad Almikhlafi,
  • Ahmed J. Aldhafiri,
  • Ali Alalawi,
  • Muayad Albadrani,
  • Ahmad Bakur Mahmoud and
  • Mekky M. Abouzied

17 December 2024

Background and aim: Being a central organ in homeostasis and maintaining the health of the biological system, kidneys are exposed to variable toxicants. Long-term exposure to nephrotoxic molecules causes chronic renal damage that causes fibrosis and...

(This article belongs to the Special Issue Common and Novel Markers of Inflammation and Tissue Damage in Various Pathological Conditions)
  • Review
  • Open Access
4 Citations
4,375 Views
16 Pages

International Nephrology Masterclass in Chronic Kidney Disease: Rationale, Summary, and Future Perspectives

  • Francesco Pesce,
  • Maria Vadalà,
  • Edgar Almeida,
  • Beatriz Fernandez,
  • Denis Fouque,
  • Jolanta Malyszko,
  • Kai Schmidt-Ott,
  • Peter Stenvinkel,
  • David C. Wheeler and
  • Loreto Gesualdo
  • + 18 authors

17 December 2024

Chronic kidney disease (CKD) is a progressive condition that affects more than 10% of the population worldwide, accounting for more than 843 million (M) individuals. The prevalence of CKD (844 M patients) is higher than that of diabetes mellitus (422...

(This article belongs to the Special Issue Feature Papers in Medical Research: 3rd Edition)
  • Review
  • Open Access
8 Citations
4,861 Views
15 Pages

Parvovirus B19 in Pregnancy—Do We Screen for Fifth Disease or Not?

  • Andrei Mihai Malutan,
  • Cristina Mihaela Ormindean,
  • Doru Diculescu,
  • Razvan Ciortea,
  • Renata Nicula,
  • Daria Pop,
  • Carmen Bucuri,
  • Roman Maria,
  • Ionel Nati and
  • Dan Mihu

16 December 2024

Parvovirus B19 (B19V) infection is the cause of erythema infectiosum, or the “fifth disease”, a widespread infection, potentially affecting 1–5% of pregnant women, in most cases without significant damage to the pregnancy or fetus....

(This article belongs to the Section Microbiology)
  • Article
  • Open Access
3 Citations
4,570 Views
12 Pages

16 December 2024

Background: The objective of this study was to examine the impacts of absolute cuff pressure blood flow restriction (A-BFR) training and incremental cuff pressure blood flow restriction (I-BFR) training, under equal cuff pressures, on body compositio...

(This article belongs to the Special Issue Focus on Exercise Physiology and Sports Performance: 2nd Edition)
  • Review
  • Open Access
11 Citations
16,703 Views
16 Pages

Gestational Diabetes Mellitus: New Thinking on Diagnostic Criteria

  • Jiyu Luo,
  • Ling Tong,
  • Ao Xu,
  • Yihan He,
  • Haiyun Huang,
  • Dongmei Qiu,
  • Xiaoyu Guo,
  • Hongli Chen,
  • Lingyun Xu and
  • Yuanyuan Li
  • + 2 authors

16 December 2024

Currently, there is a lack of standardized diagnostic criteria for gestational diabetes mellitus (GDM), making it a subject of ongoing debate. The optimal diagnostic method and screening strategy for GDM remain contentious. In this review, we summari...

(This article belongs to the Special Issue Personalized Prevention and Treatment in Endocrinology, Diabetes and Metabolic Diseases)
  • Systematic Review
  • Open Access
6 Citations
6,070 Views
12 Pages

Survival Prognostic Factors of Non-Invasive Ventilation in Amyotrophic Lateral Sclerosis: A Systematic Review

  • Aleksandra Orlova,
  • Yaroslav Malygin,
  • Anna Gofman,
  • Sofija Sotulenko,
  • Veronika Gandalian,
  • Ioan Kartashov,
  • Lev Brylev,
  • Sergey Bolevich,
  • Tamara Nikolic Turnic and
  • Vladimir Jakovljevic

16 December 2024

Objective: Amyotrophic lateral sclerosis is a neurodegenerative disease with high rates of disability and mortality. Non-invasive ventilation (NIV) is an effective method of treating patients, increasing life expectancy, but currently, predictors ava...

(This article belongs to the Section Medical Research)
  • Article
  • Open Access
3 Citations
2,235 Views
13 Pages

Inhibitor of DNA Binding Protein 2 (ID2) Mediates the Anti-Proliferative and Pro-Differentiation Effects of Insulin-like Growth Factor-1 (IGF-1)

  • Rebecca Ssengonzi,
  • Yuye Wang,
  • Jiayi Zhou,
  • Yukako Kayashima,
  • W. H. Davin Townley-Tilson,
  • Balaji Rao,
  • Qing Ma,
  • Nobuyo Maeda-Smithies and
  • Feng Li

16 December 2024

In preeclampsia (PE), impaired trophoblast proliferation and differentiation are thought to cause abnormal placentation and subsequent clinical manifestations of the disease, i.e., hypertension, proteinuria, and end-organ damage. Insulin-like growth...

(This article belongs to the Section Reproductive and Developmental Biology)
  • Review
  • Open Access
1 Citations
2,066 Views
13 Pages

16 December 2024

Parkinson’s disease (PD) is the second-leading cause of death among neurodegenerative disease after Alzheimer’s disease (AD), affecting around 2% of the population. It is expected that the incidence of PD will exceed 12 million by 2040. M...

(This article belongs to the Section Cell Biology and Tissue Engineering)
  • Systematic Review
  • Open Access
11 Citations
13,266 Views
14 Pages

Effects of High-Intensity Interval Training on Blood Pressure Levels in Hypertensive Patients: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

  • Luis Romero-Vera,
  • David Ulloa-Díaz,
  • Sergio Araya-Sierralta,
  • Francisco Guede-Rojas,
  • Oscar Andrades-Ramírez,
  • Claudio Carvajal-Parodi,
  • Gustavo Muñoz-Bustos,
  • María Matamala-Aguilera and
  • Darío Martínez-García

14 December 2024

Objective: This systematic review and meta-analysis aimed to (I) evaluate the evidence on the effects of high-intensity interval training (HIIT) on systolic blood pressure (SBP) and diastolic blood pressure (DBP) in hypertensive patients; (II) determ...

(This article belongs to the Special Issue Feature Paper in Physiology and Pathology: 2nd Edition)
  • Article
  • Open Access
1 Citations
2,651 Views
14 Pages

Effects of Marigold Extract and Carophyll Red on Growth, Body Color Development, Antioxidant Properties, and Innate Immunity in the Ornamental Fish Golden Severum (Heros efasciatus)

  • Jung-Jin Park,
  • Jun-Sung Bae,
  • Chae-Won Lee,
  • Chan-Young Yang,
  • Eun-Ha Jeong,
  • Kwan-Ha Park,
  • Jung-Soo Seo,
  • Mun-Gyeong Kwon and
  • Ji-Hoon Lee

13 December 2024

The body color state is an important determinant of the value of golden severum (Heros efasciatus)—a popular ornamental fish. The use of dietary supplements to improve the color development and health of this species is unexplored. Herein, the...

(This article belongs to the Special Issue Feature Papers in Animal Science: 3rd Edition)
  • Article
  • Open Access
12 Citations
2,564 Views
16 Pages

The Expression Profile of Genes Related to Carotenoid Biosynthesis in Pepper Under Abiotic Stress Reveals a Positive Correlation with Plant Tolerance

  • Tingli Wang,
  • Qiaoyun He,
  • Chenyuan Wang,
  • Zhimin Li,
  • Shitao Sun,
  • Xiai Yang,
  • Xiushi Yang,
  • Yanchun Deng and
  • Chunsheng Hou

13 December 2024

In light of the increasingly adverse environmental conditions and the concomitant challenges to the survival of important crops, there is a pressing need to enhance the resilience of pepper seedlings to extreme weather. Carotenoid plays an important...

(This article belongs to the Special Issue Physiological Responses of Plants Under Abiotic Stresses)
  • Article
  • Open Access
5 Citations
3,444 Views
14 Pages

Histological Findings in Infective Endocarditis—A Retrospective Cohort Study Conducted at “Dr. Carol Davila” Central Military Emergency University Hospital in Bucharest

  • Corina-Ioana Anton,
  • Ion Ștefan,
  • Sorin Duțulescu,
  • Florica Stăniceanu,
  • Cosmin Alexandru Buzilă,
  • Alexia-Teodora Ștefan and
  • Adrian Streinu-Cercel

13 December 2024

Background: Histological findings of infective endocarditis (IEs) in mechanical valves present a complex diagnostic challenge owing to the lack of a precise definition. This ambiguity is further complicated by the natural degenerative processes that...

(This article belongs to the Section Physiology and Pathology)
  • Systematic Review
  • Open Access
10 Citations
3,597 Views
26 Pages

Noninvasive Electrical Modalities to Alleviate Respiratory Deficits Following Spinal Cord Injury

  • Niraj Singh Tharu,
  • Aastha Suthar,
  • Yury Gerasimenko,
  • Camilo Castillo,
  • Alex Ng and
  • Alexander Ovechkin

13 December 2024

(1) Background: Respiratory dysfunction is a debilitating consequence of cervical and thoracic spinal cord injury (SCI), resulting from the loss of cortico-spinal drive to respiratory motor networks. This impairment affects both central and periphera...

(This article belongs to the Special Issue Spinal Neuromodulation: From Basic and Translational Research to Clinical Practice)

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