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Cells, Volume 9, Issue 10

October 2020 - 193 articles

Cover Story: Immune cells not only defend against pathogens, they also survey the metabolic state of organs. In the paper by Diehl et al. in this issue of Cells, the authors studied how fat is deposited in hepatocytes in a high fat diet animal model, a process called steatosis. In addition to hepatocytes, the liver contains tissue macrophages, the Kupffer cells. When hepatocytes from lean animals were exposed to the culture supernatant of Kupffer cells from fat animals, they became steatotic. The signaling factor TNF is a key player in this process, since blocking signaling by TNF also prevented the development of steatosis. These experiments show that the Kupffer cell acts as a sensor for metabolic overload by excess fatty acid and secretes TNF to instruct the hepatocytes to store fat. View this paper
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Articles (193)

  • Article
  • Open Access
23 Citations
5,808 Views
25 Pages

Complexity of Brassica oleraceaAlternaria brassicicola Susceptible Interaction Reveals Downregulation of Photosynthesis at Ultrastructural, Transcriptional, and Physiological Levels

  • Violetta Katarzyna Macioszek,
  • Magdalena Gapińska,
  • Agnieszka Zmienko,
  • Mirosław Sobczak,
  • Andrzej Skoczowski,
  • Jakub Oliwa and
  • Andrzej Kiejstut Kononowicz

20 October 2020

Black spot disease, caused by Alternaria brassicicola in Brassica species, is one of the most devastating diseases all over the world, especially since there is no known fully resistant Brassica cultivar. In this study, the visualization of black spo...

  • Editorial
  • Open Access
7 Citations
3,043 Views
3 Pages

19 October 2020

The incidence and prevalence of cardiac diseases, which are the main cause of death worldwide, are likely to increase because of population ageing and changes in lifestyle. Prevailing theories about the mechanisms of cardiac disease onset feature the...

  • Article
  • Open Access
6 Citations
3,515 Views
12 Pages

The miRNA Profile in Non-Hodgkin’s Lymphoma Patients with Secondary Myelodysplasia

  • Yuliya Andreevna Veryaskina,
  • Sergei Evgenievich Titov,
  • Igor Borisovich Kovynev,
  • Tatiana Ivanovna Pospelova and
  • Igor Fyodorovich Zhimulev

19 October 2020

Myelodysplastic syndromes are a group of clonal diseases of hematopoietic stem cells and are characterized by multilineage dysplasia, ineffective hematopoiesis, peripheral blood cytopenias, genetic instability and a risk of transformation to acute my...

  • Article
  • Open Access
24 Citations
6,201 Views
27 Pages

19 October 2020

Plant cell walls play an important role in shaping the defense strategies of plants. This research demonstrates the influence of two differentiators: the lifestyle and properties of the Trichoderma species on cell wall changes in common wheat seedlin...

  • Article
  • Open Access
15 Citations
5,612 Views
25 Pages

Single Cell ADNP Predictive of Human Muscle Disorders: Mouse Knockdown Results in Muscle Wasting

  • Oxana Kapitansky,
  • Gidon Karmon,
  • Shlomo Sragovich,
  • Adva Hadar,
  • Meishar Shahoha,
  • Iman Jaljuli,
  • Lior Bikovski,
  • Eliezer Giladi,
  • Robert Palovics and
  • Tal Iram
  • + 1 author

19 October 2020

Activity-dependent neuroprotective protein (ADNP) mutations are linked with cognitive dysfunctions characterizing the autistic-like ADNP syndrome patients, who also suffer from delayed motor maturation. We thus hypothesized that ADNP is deregulated i...

  • Review
  • Open Access
36 Citations
5,647 Views
22 Pages

Epigenetics in Liver Fibrosis: Could HDACs be a Therapeutic Target?

  • Alex Claveria-Cabello,
  • Leticia Colyn,
  • Maria Arechederra,
  • Jesus M. Urman,
  • Carmen Berasain,
  • Matias A. Avila and
  • Maite G. Fernandez-Barrena

19 October 2020

Chronic liver diseases (CLD) represent a worldwide health problem. While CLDs may have diverse etiologies, a common pathogenic denominator is the presence of liver fibrosis. Cirrhosis, the end-stage of CLD, is characterized by extensive fibrosis and...

  • Article
  • Open Access
8 Citations
3,446 Views
19 Pages

Effects of Coronavirus Persistence on the Genome Structure and Subsequent Gene Expression, Pathogenicity and Adaptation Capability

  • Ching-Hung Lin,
  • Cheng-Yao Yang,
  • Meilin Wang,
  • Shan-Chia Ou,
  • Chen-Yu Lo,
  • Tsung-Lin Tsai and
  • Hung-Yi Wu

19 October 2020

Coronaviruses are able to establish persistence. However, how coronaviruses react to persistence and whether the selected viruses have altered their characteristics remain unclear. In this study, we found that the persistent infection of bovine coron...

  • Article
  • Open Access
15 Citations
3,949 Views
18 Pages

Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity

  • Anupriya Chatterjee,
  • Rachana Eshwaran,
  • Gernot Poschet,
  • Santosh Lomada,
  • Mahmoud Halawa,
  • Kerstin Wilhelm,
  • Martina Schmidt,
  • Hans-Peter Hammes,
  • Thomas Wieland and
  • Yuxi Feng

19 October 2020

Our previous studies identified that retinal endothelial damage caused by hyperglycemia or nucleoside diphosphate kinase-B (NDPK-B) deficiency is linked to elevation of angiopoietin-2 (Ang-2) and the activation of the hexosamine biosynthesis pathway...

  • Article
  • Open Access
3 Citations
3,156 Views
15 Pages

SRSF3 Is a Critical Requirement for Inclusion of Exon 3 of BIS Pre-mRNA

  • Ji-Ye Baek,
  • Hye-Hyeon Yun,
  • Soon-Young Jung,
  • Jeehan Lee,
  • Kyunghyun Yoo and
  • Jeong-Hwa Lee

19 October 2020

BCL-2 interacting cell death suppressor (BIS), also known as BAG3, is a multifunctional protein. Aberrant expression and mutation of BIS have been implicated in cancers and myopathy. However, there have only been a few studies on the splicing of BIS...

  • Article
  • Open Access
13 Citations
5,604 Views
18 Pages

Clock-Controlled Mitochondrial Dynamics Correlates with Cyclic Pregnenolone Synthesis

  • Melissa Witzig,
  • Amandine Grimm,
  • Karen Schmitt,
  • Imane Lejri,
  • Stephan Frank,
  • Steven A. Brown and
  • Anne Eckert

19 October 2020

Neurosteroids are steroids synthetized in the nervous system, with the first step of steroidogenesis taking place within mitochondria with the synthesis of pregnenolone. They exert important brain-specific functions by playing a role in neurotransmis...

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Cells - ISSN 2073-4409