Table of Contents
Cells, Volume 9, Issue 10 (October 2020) – 193 articles
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Cover Story (view full-size image) Immune cells not only defend against pathogens, they also survey the metabolic state of organs. In [...] Read more. Immune cells not only defend against pathogens, they also survey the metabolic state of organs. In the paper by Diehl et al. in this issue of Cells, the authors studied how fat is deposited in hepatocytes in a high fat diet animal model, a process called steatosis. In addition to hepatocytes, the liver contains tissue macrophages, the Kupffer cells. When hepatocytes from lean animals were exposed to the culture supernatant of Kupffer cells from fat animals, they became steatotic. The signaling factor TNF is a key player in this process, since blocking signaling by TNF also prevented the development of steatosis. These experiments show that the Kupffer cell acts as a sensor for metabolic overload by excess fatty acid and secretes TNF to instruct the hepatocytes to store fat. View this paper