Cells 2019, 8(2), 104; https://doi.org/10.3390/cells8020104
Control of the Antitumor Immune Response by Cancer Metabolism
1
Bordeaux University, CNRS, UMR 5164, ImmunoConcEpT, 33000 Bordeaux, France
2
Department of Medical Oncology, Hôpital Saint-André, Bordeaux University Hospital-CHU, 33000 Bordeaux, France
3
Curematch, Inc., 6440 Lusk Bvld, San Diego, CA 92121, USA
4
Cellomet, CGFB, 146 Rue léo Saignat, F-33000 Bordeaux, France
†
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 22 December 2018 / Revised: 25 January 2019 / Accepted: 28 January 2019 / Published: 31 January 2019
(This article belongs to the Section Cell Signaling and Regulated Cell Death)
Abstract
The metabolic reprogramming of tumor cells and immune escape are two major hallmarks of cancer cells. The metabolic changes that occur during tumorigenesis, enabling survival and proliferation, are described for both solid and hematological malignancies. Concurrently, tumor cells have deployed mechanisms to escape immune cell recognition and destruction. Additionally, therapeutic blocking of tumor-mediated immunosuppression has proven to have an unprecedented positive impact in clinical oncology. Increased evidence suggests that cancer metabolism not only plays a crucial role in cancer signaling for sustaining tumorigenesis and survival, but also has wider implications in the regulation of antitumor immune signaling through both the release of signaling molecules and the expression of immune membrane ligands. Here, we review these molecular events to highlight the contribution of cancer cell metabolic reprogramming on the shaping of the antitumor immune response. View Full-TextKeywords:
cancer; metabolism; immunity
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Domblides, C.; Lartigue, L.; Faustin, B. Control of the Antitumor Immune Response by Cancer Metabolism. Cells 2019, 8, 104.
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