Control of the Antitumor Immune Response by Cancer Metabolism
AbstractThe metabolic reprogramming of tumor cells and immune escape are two major hallmarks of cancer cells. The metabolic changes that occur during tumorigenesis, enabling survival and proliferation, are described for both solid and hematological malignancies. Concurrently, tumor cells have deployed mechanisms to escape immune cell recognition and destruction. Additionally, therapeutic blocking of tumor-mediated immunosuppression has proven to have an unprecedented positive impact in clinical oncology. Increased evidence suggests that cancer metabolism not only plays a crucial role in cancer signaling for sustaining tumorigenesis and survival, but also has wider implications in the regulation of antitumor immune signaling through both the release of signaling molecules and the expression of immune membrane ligands. Here, we review these molecular events to highlight the contribution of cancer cell metabolic reprogramming on the shaping of the antitumor immune response. View Full-Text
Share & Cite This Article
Domblides, C.; Lartigue, L.; Faustin, B. Control of the Antitumor Immune Response by Cancer Metabolism. Cells 2019, 8, 104.
Domblides C, Lartigue L, Faustin B. Control of the Antitumor Immune Response by Cancer Metabolism. Cells. 2019; 8(2):104.Chicago/Turabian Style
Domblides, Charlotte; Lartigue, Lydia; Faustin, Benjamin. 2019. "Control of the Antitumor Immune Response by Cancer Metabolism." Cells 8, no. 2: 104.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.