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Cells, Volume 12, Issue 14

July-2 2023 - 112 articles

Cover Story: The prominent pathological change in prion-affected brains is neuroinflammation and aggregation of pathogenic prions. We investigated the impact of innate immune responses on prion replication in vitro. Glial cells from the cerebellum were susceptible to HY, but resistant to DY prion as determined by Western blot analysis, immunocytochemistry, and animal bioassay. However, glial cells from the cerebral cortex were refractory to both strains. Priming glial cells with lipopolysaccharide decreased prion replication, whereas pre-treatment with dexamethasone inhibiting innate immunity increased susceptibility to DY infection. Our results suggest that neuroinflammation resulting from prion infection might be an attempt to resolve prion propagation, implying a therapeutic potential of innate immune modulation in the early stages of prion disease. View this paper
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Articles (112)

  • Review
  • Open Access
35 Citations
8,074 Views
16 Pages

Liquid Biopsy in Neurological Diseases

  • Sunny Malhotra,
  • Mari Carmen Martín Miras,
  • Agustín Pappolla,
  • Xavier Montalban and
  • Manuel Comabella

22 July 2023

The most recent and non-invasive approach for studying early-stage biomarkers is liquid biopsy. This implies the extraction and analysis of non-solid biological tissues (serum, plasma, saliva, urine, and cerebrospinal fluid) without undergoing invasi...

  • Review
  • Open Access
7 Citations
3,094 Views
15 Pages

The Emerging Role of Innate Lymphoid Cells (ILCs) and Alarmins in Celiac Disease: An Update on Pathophysiological Insights, Potential Use as Disease Biomarkers, and Therapeutic Implications

  • Angela Rizzi,
  • Mario Di Gioacchino,
  • Luca Gammeri,
  • Riccardo Inchingolo,
  • Raffaella Chini,
  • Francesca Santilli,
  • Eleonora Nucera and
  • Sebastiano Gangemi

21 July 2023

Celiac disease (CD) is an intestinal disease that develops in genetically predisposed individuals and is triggered by the ingestion of gluten. CD was considered a Th1-disease. Today, the role of Th17, IL-21, and IL-17A lymphocytes is well known. Infl...

  • Article
  • Open Access
7 Citations
2,865 Views
17 Pages

Early Detection of Pre-Cancerous and Cancerous Cells Using Raman Spectroscopy-Based Machine Learning

  • Uraib Sharaha,
  • Daniel Hania,
  • Itshak Lapidot,
  • Ahmad Salman and
  • Mahmoud Huleihel

21 July 2023

Cancer is the most common and fatal disease around the globe, with an estimated 19 million newly diagnosed patients and approximately 10 million deaths annually. Patients with cancer struggle daily due to difficult treatments, pain, and financial and...

  • Article
  • Open Access
7 Citations
3,150 Views
11 Pages

21 July 2023

In a survey of the International Space Station (ISS), the most common pathogenic bacterium identified in samples from the air, water and surfaces was Staphylococcus aureus. While growth under microgravity is known to cause physiological changes in mi...

  • Correction
  • Open Access
1 Citations
1,106 Views
2 Pages

21 July 2023

The authors wish to make the following change to their paper [...]

  • Article
  • Open Access
7 Citations
3,214 Views
21 Pages

Autophagy Inhibition with Chloroquine Increased Pro-Apoptotic Potential of New Aziridine-Hydrazide Hydrazone Derivatives against Glioblastoma Cells

  • Monika Witusik-Perkowska,
  • Pola Głowacka,
  • Adam M. Pieczonka,
  • Ewa Świderska,
  • Agnieszka Pudlarz,
  • Michał Rachwalski,
  • Julia Szymańska,
  • Magdalena Zakrzewska,
  • Dariusz J. Jaskólski and
  • Janusz Szemraj

21 July 2023

Tumor therapy escape due to undesired side effects induced by treatment, such as prosurvival autophagy or cellular senescence, is one of the key mechanisms of resistance that eventually leads to tumor dormancy and recurrence. Glioblastoma is the most...

  • Review
  • Open Access
15 Citations
5,430 Views
26 Pages

Management of Rheumatoid Arthritis: Possibilities and Challenges of Mesenchymal Stromal/Stem Cell-Based Therapies

  • Yusuke Shimizu,
  • Edward Hosea Ntege,
  • Chinatsu Azuma,
  • Fuminari Uehara,
  • Takashi Toma,
  • Kotaro Higa,
  • Hiroki Yabiku,
  • Naoki Matsuura,
  • Yoshikazu Inoue and
  • Hiroshi Sunami

21 July 2023

Rheumatoid arthritis (RA) is a highly prevalent, chronic, and progressive autoimmune disorder primarily affecting joints and muscles. The associated inflammation, pain, and motor restriction negatively impact patient quality of life (QOL) and can eve...

  • Review
  • Open Access
3 Citations
3,128 Views
23 Pages

Unravelling the Role of PARP1 in Homeostasis and Tumorigenesis: Implications for Anti-Cancer Therapies and Overcoming Resistance

  • Taylor Lovsund,
  • Fatemeh Mashayekhi,
  • Amira Fitieh,
  • James Stafford and
  • Ismail Hassan Ismail

21 July 2023

Detailing the connection between homeostatic functions of enzymatic families and eventual progression into tumorigenesis is crucial to our understanding of anti-cancer therapies. One key enzyme group involved in this process is the Poly (ADP-ribose)...

  • Review
  • Open Access
9 Citations
4,710 Views
17 Pages

Targeting Soluble Guanylyl Cyclase during Ischemia and Reperfusion

  • Eric H. Mace,
  • Melissa J. Kimlinger,
  • Frederic T. Billings and
  • Marcos G. Lopez

21 July 2023

Ischemia and reperfusion (IR) damage organs and contribute to many disease states. Few effective treatments exist that attenuate IR injury. The augmentation of nitric oxide (NO) signaling remains a promising therapeutic target for IR injury. NO binds...

  • Article
  • Open Access
3 Citations
3,722 Views
14 Pages

FITC-Labeled RGD Peptides as Novel Contrast Agents for Functional Fluorescent Angiographic Detection of Retinal and Choroidal Neovascularization

  • Seung Woo Choi,
  • Hye Kyoung Hong,
  • Jehwi Jeon,
  • Ji Young Choi,
  • Minah Kim,
  • Pilhan Kim,
  • Byung Chul Lee and
  • Se Joon Woo

21 July 2023

The development of choroidal neovascularization (CNV) is a crucial factor in the pathophysiology and prognosis of exudative age-related macular degeneration (AMD). Therefore, the detection of CNV is essential for establishing an appropriate diagnosis...

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Cells - ISSN 2073-4409