Cells, Volume 11, Issue 19
October-1 2022 - 253 articles
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Cover Story: The transport of low-density lipoprotein (LDL) through the endothelium is a key step in atherosclerosis development, but it is notorious that phenotypic differences exist between endothelial cells (ECs) originating from different vascular beds. Here, we systematically compared brain versus aortic ECs regarding their interaction with LDL and observed that both EC types bind and internalize LDL. However, whereas aortic ECs degrade very small amounts of LDL and transcytose the majority, brain EC degrade but do not transport LDL. We found that the LDLR–clathrin pathway leads to LDL degradation in either EC type, whereas ALK1, which promotes LDL transport in aortic ECs, limits LDL degradation in brain ECs. Finally, neither SR-BI nor caveolin-1, which promote LDL uptake and transport into aortic ECs, limit LDL binding and association in brain ECs. View this paper 
