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Cells, Volume 11, Issue 15

August-1 2022 - 204 articles

Cover Story: Urolithiasis is a risk factor for the development of chronic kidney disease that has been clinically correlated with cardiovascular disorders. Here, we first demonstrate that hyperoxaluria induces endothelial dysfunction mediated by oxidative stress in renal preglomerular arteries. Xanthine oxidase, pathway, Nox1 and in particular Nox2 contribute to the enhanced reactive oxygen species levels in the renal cortex of hyperoxaluric rats, which generates endothelial dysfunction in the nearby arteries. Inhibition of these enzymes restores impaired endothelial vasodilatation. An inflammatory response is also generated in the vascular endothelium through the activation of the redox-sensitive NF-κB pathway. The current data suggest that oxidative stress-mediated endothelial dysfunction induced by hyperoxaluria might contribute to the vascular renal damage associated with nephrolithiasis. View this paper
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Articles (204)

  • Review
  • Open Access
19 Citations
9,618 Views
15 Pages

7 August 2022

During its division the cell must ensure the equal distribution of its genetic material in the two newly created cells, but it must also distribute organelles such as the Golgi apparatus, the mitochondria and the centrosome. DNA, the carrier of hered...

  • Review
  • Open Access
17 Citations
5,005 Views
17 Pages

Could Experimental Inflammation Provide Better Understanding of Migraines?

  • Philip Victor Reducha,
  • Lars Edvinsson and
  • Kristian Agmund Haanes

6 August 2022

Migraines constitute a common neurological and headache disorder affecting around 15% of the world’s population. In addition to other mechanisms, neurogenic neuroinflammation has been proposed to play a part in migraine chronification, which in...

  • Article
  • Open Access
35 Citations
4,416 Views
15 Pages

6 August 2022

Lipid rafts play important roles in signal transduction, particularly in responses to inflammatory processes. The current study aimed to identify whether lipid raft-mediated inflammation contributes to hyperhomocysteinemia (HHcy)-accelerated atherosc...

  • Feature Paper
  • Article
  • Open Access
6 Citations
2,666 Views
14 Pages

lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via trans-Regulatory Actions

  • Bohao Zhao,
  • Jiali Li,
  • Ming Liu,
  • Shuaishuai Hu,
  • Naisu Yang,
  • Shuang Liang,
  • Xiyu Zhang,
  • Yingying Dai,
  • Zhiyuan Bao and
  • Yang Chen
  • + 1 author

6 August 2022

Hair follicles (HFs) are complex organs that grow cyclically during mammals’ growth and development. Long non-coding RNAs (lncRNAs) cannot be translated into proteins and play crucial roles in many biological processes. In our previous study, c...

  • Review
  • Open Access
3 Citations
4,902 Views
21 Pages

6 August 2022

Quorum sensing (QS) was historically described as a mechanism by which bacteria detect and optimize their population density via gene regulation based on dynamic environmental cues. Recently, it was proposed that QS or similar mechanisms may have bro...

  • Article
  • Open Access
11 Citations
5,705 Views
21 Pages

The Gluopsins: Opsins without the Retinal Binding Lysine

  • Martin Gühmann,
  • Megan L. Porter and
  • Michael J. Bok

6 August 2022

Opsins allow us to see. They are G-protein-coupled receptors and bind as ligand retinal, which is bound covalently to a lysine in the seventh transmembrane domain. This makes opsins light-sensitive. The lysine is so conserved that it is used to defin...

  • Communication
  • Open Access
6 Citations
3,600 Views
13 Pages

6 August 2022

In obesity, chronic membrane-localization of CD36 free fatty acid (FFA) translocase, but not other FFA transporters, enhances FFA uptake and intracellular lipid accumulation. This ectopic lipid accumulation promotes insulin resistance by inhibiting i...

  • Review
  • Open Access
390 Citations
41,704 Views
46 Pages

Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements

  • Praveen Kolimi,
  • Sagar Narala,
  • Dinesh Nyavanandi,
  • Ahmed Adel Ali Youssef and
  • Narendar Dudhipala

6 August 2022

Wound healing is highly specialized dynamic multiple phase process for the repair of damaged/injured tissues through an intricate mechanism. Any failure in the normal wound healing process results in abnormal scar formation, and chronic state which i...

  • Article
  • Open Access
4 Citations
2,767 Views
16 Pages

Add-On Cyclic Angiotensin-(1-7) with Cyclophosphamide Arrests Progressive Kidney Disease in Rats with ANCA Associated Glomerulonephritis

  • Domenico Cerullo,
  • Daniela Rottoli,
  • Daniela Corna,
  • Mauro Abbate,
  • Ariela Benigni,
  • Giuseppe Remuzzi and
  • Carlamaria Zoja

5 August 2022

Rapidly progressive crescentic glomerulonephritis associated with anti-neutrophil cytoplasmic antibodies (ANCA-GN) is a major cause of renal failure. Current immunosuppressive therapies are associated with severe side effects, intensifying the need f...

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Cells - ISSN 2073-4409