Modification of PMMA Cements for Cranioplasty with Bioactive Glass and Copper Doped Tricalcium Phosphate Particles

Russo, Teresa; De Santis, Roberto; Gloria, Antonio; Barbaro, Katia; Altigeri, Annalisa; Fadeeva, Inna V.; Rau, Julietta V.

doi:10.3390/polym12010037

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Modification of PMMA Cements for Cranioplasty with Bioactive Glass and Copper Doped Tricalcium Phosphate Particles

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Institute of Polymers, Composites and Biomaterials, National Research Council of Italy, V.le J.F. Kennedy 54-Mostra d’Oltremare Pad. 20, 80125 Naples, Italy

Istituto Zooprofilattico Sperimentale Lazio e Toscana “M. Aleandri”, Via Appia Nuova 1411, 00178 Rome, Italy

AA Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Leninsky prospect 49, 119334 Moscow, Russia

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Istituto di Struttura della Materia, Consiglio Nazionale delle Ricerche (ISM-CNR), Via del Fosso del Cavaliere 100, 00133 Rome, Italy

Author to whom correspondence should be addressed.

Polymers 2020, 12(1), 37; https://doi.org/10.3390/polym12010037

Received: 15 November 2019 / Revised: 13 December 2019 / Accepted: 17 December 2019 / Published: 25 December 2019

(This article belongs to the Section Polymer Physics and Theory)

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Abstract

Cranioplasty represents the surgical repair of bone defects or deformities in the cranium arising from traumatic skull bone fracture, cranial bone deformities, bone cancer, and infections. The actual gold standard in surgery procedures for cranioplasty involves the use of biocompatible materials, and repair or regeneration of large cranial defects is particularly challenging from both a functional and aesthetic point of view. PMMA-based bone cement are the most widely biomaterials adopted in the field, with at least four different surgical approaches. Modifications for improving biological and mechanical functions of PMMA-based bone cement have been suggested. To this aim, the inclusion of antibiotics to prevent infection has been shown to provide a reduction of mechanical properties in bending. Therefore, the development of novel antibacterial active agents to overcome issues related to mechanical properties and bacterial resistance to antibiotics is still encouraged. In this context, mechanical, biological, and antibacterial feature against P. aeruginosa and S. aureus bacterial strains of surgical PMMA cement modified with BG and recently developed Cu-TCP bioactive particles have been highlighted. View Full-Text

Keywords: cranioplasty; PMMA; biocomposites; bioactive particles; bending properties; compressive properties; MTT assay; bacterial strains

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MDPI and ACS Style

Russo, T.; De Santis, R.; Gloria, A.; Barbaro, K.; Altigeri, A.; Fadeeva, I.V.; Rau, J.V. Modification of PMMA Cements for Cranioplasty with Bioactive Glass and Copper Doped Tricalcium Phosphate Particles. Polymers 2020, 12, 37. https://doi.org/10.3390/polym12010037

AMA Style

Russo T, De Santis R, Gloria A, Barbaro K, Altigeri A, Fadeeva IV, Rau JV. Modification of PMMA Cements for Cranioplasty with Bioactive Glass and Copper Doped Tricalcium Phosphate Particles. Polymers. 2020; 12(1):37. https://doi.org/10.3390/polym12010037

Chicago/Turabian Style

Russo, Teresa, Roberto De Santis, Antonio Gloria, Katia Barbaro, Annalisa Altigeri, Inna V. Fadeeva, and Julietta V. Rau. 2020. "Modification of PMMA Cements for Cranioplasty with Bioactive Glass and Copper Doped Tricalcium Phosphate Particles" Polymers 12, no. 1: 37. https://doi.org/10.3390/polym12010037

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Modification of PMMA Cements for Cranioplasty with Bioactive Glass and Copper Doped Tricalcium Phosphate Particles

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