Table of Contents
Cancers, Volume 9, Issue 9 (September 2017)
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Cover Story (view full-size image) Adoptive T cell transfer (ACT) using chimeric antigen receptors (CARs) has shown impressive [...] Read more. Adoptive T cell transfer (ACT) using chimeric antigen receptors (CARs) has shown impressive clinical outcomes in leukemias and is now being explored in solid tumors. One target is malignant pleural mesothelioma (MPM), a pleural cancer with poor prognosis for which no effective treatment exists. Clinical trials using CARs are underway to target the tumor surface protein, mesothelin, and the cancer fibroblast surface protein, fibroblast activation protein. Preclinical studies targeting other attractive protein targets, as well as strategies to augment the function of CAR T cells, are also under way. View the paper