Special Issue "DNA Repair Pathways in Cancer"
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (31 January 2017)
Prof. Dr. Eddy S. Yang
Department of Radiation Oncology, University of Alabama-Birmingham, 1720 2nd Ave South, Birmingham, AL 35294, USA
Website | E-Mail
Interests: PARP, DNA repair, BRCA1, BRCA2, EGFR, synthetic lethality, experimental therapeutics, breast cancer, ovarian cancer, prostate cancer, head and neck cancer
Genomic instability and DNA repair defects are a hallmark of cancer that is more prevalent than previously thought. Recent data from genetic studies, most notably from The Cancer Genome Atlas (TCGA) projects, have shown many tumor types to harbor genetic and epigenetic alterations in DNA repair pathways. These data have made the targeting of DNA repair proteins for cancer therapy increasingly attractive, especially given the recent successes of the PARP inhibitors. Furthermore, as resistance to therapy remains a clinical challenge, combinations of targeted therapies are needed. Moreover, the DNA damage response has crosstalk with inflammation and immune pathways. This and the fact that genomic instability can increase mutational burden and increase neoantigen presentation points to potential synergies between compounds targeting DNA repair and immune therapies. This Special Issue of Cancers will review the role of DNA repair pathways in cancer biology, inflammation, and the immune system and highlight novel targets currently in clinical testing. Research articles on these topics are also welcome.
Dr. Eddy S. Yang
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.