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Open AccessArticle

Human Papillomavirus Genotype Distribution in Invasive Cervical Cancer in Pakistan

1
Department of Pathology, Shaukat Khanum Memorial Cancer Hospital and Research Centre Lahore, Punjab 54000, Pakistan
2
Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO)–IDIBELL, L’Hospitalet de Llobregat, Gran Via de l’Hospitalet, 199-203, 08908 L’Hospitalet de Llobregat, Barcelona, Spain
3
Clinical Research Office, Shaukat Khanum Memorial Cancer Hospital and Research Centre Lahore, Punjab 54000, Pakistan
4
Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO)–IDIBELL, L’Hospitalet de Llobregat, Gran Via de l’Hospitalet, 199-203, 08908 L’Hospitalet de Llobregat, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP). Madrid, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Samuel Mok
Cancers 2016, 8(8), 72; https://doi.org/10.3390/cancers8080072
Received: 31 May 2016 / Revised: 18 July 2016 / Accepted: 26 July 2016 / Published: 30 July 2016
(This article belongs to the Special Issue HPV Associated Cancers)
Few studies have assessed the burden of human papillomavirus (HPV) infection in Pakistan. We aim to provide specific information on HPV-type distribution in invasive cervical cancer (ICC) in the country. A total of 280 formalin-fixed paraffin-embedded tissue blocks were consecutively selected from Shaukat Khanum Memorial Cancer Hospital and Research Centre (Lahore, Pakistan). HPV-DNA was detected by SPF10 broad-spectrum PCR followed by DNA enzyme immunoassay and genotyping by LiPA25. HPV-DNA prevalence was 87.5% (95%CI: 83.0–91.1), with 96.1% of cases histologically classified as squamous cell carcinoma. Most of the HPV-DNA positive cases presented single infections (95.9%). HPV16 was the most common type followed by HPV18 and 45. Among HPV-DNA positive, a significantly higher contribution of HPV16/18 was detected in Pakistan (78.4%; 72.7–83.3), compared to Asia (71.6%; 69.9–73.4) and worldwide (70.8%; 69.9–71.8) and a lower contribution of HPVs31/33/45/52/58 (11.1%; 7.9–15.7 vs. 19.8%; 18.3–21.3 and 18.5%; 17.7–19.3). HPV18 or HPV45 positive ICC cases were significantly younger than cases infected by HPV16 (mean age: 43.3, 44.4, 50.5 years, respectively). A routine cervical cancer screening and HPV vaccination program does not yet exist in Pakistan; however, the country could benefit from national integrated efforts for cervical cancer prevention and control. Calculated estimations based on our results show that current HPV vaccine could potentially prevent new ICC cases. View Full-Text
Keywords: human papillomavirus; cervical cancer; genotype; epidemiology; human papillomavirus vaccines; Pakistan human papillomavirus; cervical cancer; genotype; epidemiology; human papillomavirus vaccines; Pakistan
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MDPI and ACS Style

Loya, A.; Serrano, B.; Rasheed, F.; Tous, S.; Hassan, M.; Clavero, O.; Raza, M.; De Sanjosé, S.; Bosch, F.X.; Alemany, L. Human Papillomavirus Genotype Distribution in Invasive Cervical Cancer in Pakistan. Cancers 2016, 8, 72. https://doi.org/10.3390/cancers8080072

AMA Style

Loya A, Serrano B, Rasheed F, Tous S, Hassan M, Clavero O, Raza M, De Sanjosé S, Bosch FX, Alemany L. Human Papillomavirus Genotype Distribution in Invasive Cervical Cancer in Pakistan. Cancers. 2016; 8(8):72. https://doi.org/10.3390/cancers8080072

Chicago/Turabian Style

Loya, Asif; Serrano, Beatriz; Rasheed, Farah; Tous, Sara; Hassan, Mariam; Clavero, Omar; Raza, Muhammad; De Sanjosé, Silvia; Bosch, F. X.; Alemany, Laia. 2016. "Human Papillomavirus Genotype Distribution in Invasive Cervical Cancer in Pakistan" Cancers 8, no. 8: 72. https://doi.org/10.3390/cancers8080072

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