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Cancers, Volume 13, Issue 13

July-1 2021 - 277 articles

Cover Story: The rapid improvement of next-generation sequencing (NGS) technologies, as well as their numerous applications in large-scale cohorts, has enabled vital advances in cancer research. However, the accumulation of NGS data has led to challenges that are commonly related to big data. Thus, sophisticated data analysis methods that incorporate systems biology and machine learning (ML) have become indispensable. The review by Park et al. provides a detailed summary of tailored ML and systems biology approaches and combinations thereof that tackle the various difficulties that arise in the face of big data. Moreover, it gives an overview of the numerous applications of artificial intelligence, aiding the analysis and interpretation of NGS data for molecular characterization, tumor heterogeneity, or cancer drug discovery, for instance. View this paper
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Articles (277)

  • Article
  • Open Access
10 Citations
3,166 Views
12 Pages
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Combination of the G-8 Screening Tool and Hand-Grip Strength to Predict Long-Term Overall Survival in Non-Small Cell Lung Cancer Patients Undergoing Stereotactic Body Radiotherapy

  • Kristian Kirkelund Bentsen,
  • Olfred Hansen,
  • Jesper Ryg,
  • Ann-Kristine Weber Giger and
  • Stefan Starup Jeppesen
Cancers2021, 13(13), 3363;https://doi.org/10.3390/cancers13133363

5 July 2021

The Geriatric 8 (G-8) is a known predictor of overall survival (OS) in older cancer patients, but is mainly based on nutritional aspects. This study aimed to assess if the G-8 combined with a hand-grip strength test (HGST) in patients with NSCLC trea...

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  • Article
  • Open Access
17 Citations
4,765 Views
16 Pages
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Neuroblastoma Molecular Risk-Stratification of DNA Copy Number and ALK Genotyping via Cell-Free Circulating Tumor DNA Profiling

  • Smadar Kahana-Edwin,
  • Lucy E. Cain,
  • Geoffrey McCowage,
  • Artur Darmanian,
  • Dale Wright,
  • Anna Mullins,
  • Federica Saletta and
  • Jonathan Karpelowsky
Cancers2021, 13(13), 3365;https://doi.org/10.3390/cancers13133365

5 July 2021

Background: MYCN amplification (MNA), segmental chromosomal aberrations (SCA) and ALK activating mutations are biomarkers for risk-group stratification and for targeted therapeutics for neuroblastoma, both of which are currently assessed on tissue bi...

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  • Article
  • Open Access
9 Citations
3,889 Views
24 Pages
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Single Cell Genetic Profiling of Tumors of Breast Cancer Patients Aged 50 Years and Older Reveals Enormous Intratumor Heterogeneity Independent of Individual Prognosis

  • Anna-Sophie Liegmann,
  • Kerstin Heselmeyer-Haddad,
  • Annette Lischka,
  • Daniela Hirsch,
  • Wei-Dong Chen,
  • Irianna Torres,
  • Timo Gemoll,
  • Achim Rody,
  • Christoph Thorns and
  • Edward Michael Gertz
  • + 4 authors
Cancers2021, 13(13), 3366;https://doi.org/10.3390/cancers13133366

5 July 2021

Purpose: Older breast cancer patients are underrepresented in cancer research even though the majority (81.4%) of women dying of breast cancer are 55 years and older. Here we study a common phenomenon observed in breast cancer which is a large inter-...

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  • Article
  • Open Access
3 Citations
3,052 Views
15 Pages
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Potent Anticancer Effects of Epidithiodiketopiperazine NT1721 in Cutaneous T Cell Lymphoma

  • Min Lin,
  • Claudia M. Kowolik,
  • Jun Xie,
  • Sushma Yadav,
  • Larry E. Overman and
  • David A. Horne
Cancers2021, 13(13), 3367;https://doi.org/10.3390/cancers13133367

5 July 2021

Cutaneous T cell lymphomas (CTCLs) are a heterogeneous group of debilitating, incurable malignancies. Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common subtypes, accounting for ~65% of CTCL cases. Patients with advanced disease have...

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  • Feature Paper
  • Article
  • Open Access
30 Citations
5,997 Views
17 Pages
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Physical Comorbidities and Depression in Recent and Long-Term Adult Cancer Survivors: NHANES 2007–2018

  • Dafina Petrova,
  • Andrés Catena,
  • Miguel Rodríguez-Barranco,
  • Daniel Redondo-Sánchez,
  • Eloísa Bayo-Lozano,
  • Rocio Garcia-Retamero,
  • José-Juan Jiménez-Moleón and
  • María-José Sánchez
Cancers2021, 13(13), 3368;https://doi.org/10.3390/cancers13133368

5 July 2021

Many adult cancer patients present one or more physical comorbidities. Besides interfering with treatment and prognosis, physical comorbidities could also increase the already heightened psychological risk of cancer patients. To test this possibility...

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  • Systematic Review
  • Open Access
14 Citations
6,658 Views
17 Pages
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The Incidence and Treatment Response of Double Expression of MYC and BCL2 in Patients with Diffuse Large B-Cell Lymphoma: A Systematic Review and Meta-Analysis

  • Jisun Hwang,
  • Chong Hyun Suh,
  • Kyung Won Kim,
  • Ho Sung Kim,
  • Austin I. Kim,
  • Jeffrey W. Craig,
  • Ke Xun Chen,
  • Joel Roberson,
  • Jeffrey P. Guenette and
  • Raymond Y. Huang
Cancers2021, 13(13), 3369;https://doi.org/10.3390/cancers13133369

5 July 2021

MYC/BCL2 protein co-expression (i.e., double expressor) has been shown to be a negative predictor of outcome in diffuse large B-cell lymphoma (DLBCL). We aimed to establish the incidence of double expressor status in patients with de novo DLBCL and i...

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  • Article
  • Open Access
7 Citations
3,544 Views
18 Pages
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Serum HPV16 E7 Oncoprotein Is a Recurrence Marker of Oropharyngeal Squamous Cell Carcinomas

  • Lucia Oton-Gonzalez,
  • John Charles Rotondo,
  • Carmen Lanzillotti,
  • Elisa Mazzoni,
  • Ilaria Bononi,
  • Maria Rosa Iaquinta,
  • Luca Cerritelli,
  • Nicola Malagutti,
  • Andrea Ciorba and
  • Chiara Bianchini
  • + 3 authors
Cancers2021, 13(13), 3370;https://doi.org/10.3390/cancers13133370

5 July 2021

Despite improved prognosis for many HPV-positive head and neck squamous cell carcinomas (HNSCCs), some cases are still marked by recurrence and metastasis. Our study aimed to identify novel biomarkers for patient stratification. Classical HPV markers...

Full Article
  • Review
  • Open Access
23 Citations
5,517 Views
20 Pages
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Epitranscriptomics: A New Layer of microRNA Regulation in Cancer

  • Veronica De Paolis,
  • Elisa Lorefice,
  • Elisa Orecchini,
  • Claudia Carissimi,
  • Ilaria Laudadio and
  • Valerio Fulci
Cancers2021, 13(13), 3372;https://doi.org/10.3390/cancers13133372

5 July 2021

MicroRNAs are pervasive regulators of gene expression at the post-transcriptional level in metazoan, playing key roles in several physiological and pathological processes. Accordingly, these small non-coding RNAs are also involved in cancer developme...

Full Article
  • Review
  • Open Access
57 Citations
9,212 Views
29 Pages
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Prostate Cancer Liquid Biopsy Biomarkers’ Clinical Utility in Diagnosis and Prognosis

  • Milena Matuszczak,
  • Jack A. Schalken and
  • Maciej Salagierski
Cancers2021, 13(13), 3373;https://doi.org/10.3390/cancers13133373

5 July 2021

Prostate cancer (PCa) is the most common cancer in men worldwide. The current gold standard for diagnosing PCa relies on a transrectal ultrasound-guided systematic core needle biopsy indicated after detection changes in a digital rectal examination (...

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