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Cancers, Volume 13, Issue 12

June-2 2021 - 250 articles

Cover Story: Up to one third of all breast cancers are classified as the aggressive HER2-positive subtype, which is associated with a higher risk of recurrence compared to HER2-negative breast cancers. The HER2 hyperactivity associated with this subtype drives tumor growth by up-regulation of mTOR pathways and metabolic adaptation. Combination therapies that simultaneously target HER2 and mTOR improve clinical outcomes compared with HER2 inhibition alone. Drugs that mimic glucose deprivation in HER2-positive breast cancer patients have not been evaluated; however, preclinical studies have shown that the growth of HER2-positive breast tumors is reduced in response to combining the glycolytic inhibitor 2-DG with mTOR inhibitors. Here, we review the role of mTOR, glycolysis, and signaling mechanisms in HER2-positive breast cancer. View this paper
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Articles (250)

  • Reply
  • Open Access
8 Citations
3,095 Views
5 Pages

Reply to Orlhac, F.; Buvat, I. Comment on “Ibrahim et al. The Effects of In-Plane Spatial Resolution on CT-Based Radiomic Features’ Stability with and without ComBat Harmonization. Cancers 2021, 13, 1848”

  • Abdalla Ibrahim,
  • Turkey Refaee,
  • Sergey Primakov,
  • Bruno Barufaldi,
  • Raymond J. Acciavatti,
  • Renée W. Y. Granzier,
  • Roland Hustinx,
  • Felix M. Mottaghy,
  • Henry C. Woodruff and
  • Joachim E. Wildberger
  • + 2 authors

21 June 2021

We would like to thank Orlhac and Buvat [...]

  • Article
  • Open Access
23 Citations
17,139 Views
14 Pages

Are Borrmann’s Types of Advanced Gastric Cancer Distinct Clinicopathological and Molecular Entities? A Western Study

  • Cristina Díaz del Arco,
  • Luis Ortega Medina,
  • Lourdes Estrada Muñoz,
  • Elena Molina Roldán,
  • M. Ángeles Cerón Nieto,
  • Soledad García Gómez de las Heras and
  • M. Jesús Fernández Aceñero

21 June 2021

Most studies on the clinicopathological impact of Borrmann classification for gastric cancer (GC) have been performed in Asian patients with type IV tumors, and immunohistochemical features of Borrmann types have scarcely been analyzed. We assessed t...

  • Review
  • Open Access
12 Citations
4,166 Views
16 Pages

Response Prediction and Evaluation Using PET in Patients with Solid Tumors Treated with Immunotherapy

  • Frank J. Borm,
  • Jasper Smit,
  • Daniela E. Oprea-Lager,
  • Maurits Wondergem,
  • John B. A. G. Haanen,
  • Egbert F. Smit and
  • Adrianus J. de Langen

21 June 2021

In multiple malignancies, checkpoint inhibitor therapy has an established role in the first-line treatment setting. However, only a subset of patients benefit from checkpoint inhibition, and as a result, the field of biomarker research is active. Mol...

  • Article
  • Open Access
9 Citations
4,725 Views
15 Pages

Co-Stimulatory versus Cell Death Aspects of Agonistic CD40 Monoclonal Antibody Selicrelumab in Chronic Lymphocytic Leukemia

  • Raquel Delgado,
  • Karoline Kielbassa,
  • Johanna ter Burg,
  • Christian Klein,
  • Christine Trumpfheller,
  • Koen de Heer,
  • Arnon P. Kater and
  • Eric Eldering

21 June 2021

Objectives: Chronic lymphocytic leukemia (CLL) is a common form of leukemia with a heterogeneous clinical course that remains incurable due to the development of therapy resistance. In lymph node proliferation centers, signals from the microenvironme...

  • Review
  • Open Access
16 Citations
5,852 Views
20 Pages

Ca2+ Signaling and Its Potential Targeting in Pancreatic Ductal Carcinoma

  • Louay Bettaieb,
  • Maxime Brulé,
  • Axel Chomy,
  • Mel Diedro,
  • Malory Fruit,
  • Eloise Happernegg,
  • Leila Heni,
  • Anaïs Horochowska,
  • Mahya Housseini and
  • Kekely Klouyovo
  • + 11 authors

21 June 2021

Pancreatic cancer (PC) is a major cause of cancer-associated mortality in Western countries (and estimated to be the second cause of cancer deaths by 2030). The main form of PC is pancreatic adenocarcinoma, which is the fourth most common cause of ca...

  • Review
  • Open Access
13 Citations
8,753 Views
18 Pages

Review of PP2A Tumor Biology and Antitumor Effects of PP2A Inhibitor LB100 in the Nervous System

  • Jean-Paul Bryant,
  • Adam Levy,
  • John Heiss and
  • Yeshavanth Kumar Banasavadi-Siddegowda

21 June 2021

Protein phosphatase 2A (PP2A) is a ubiquitous serine/threonine phosphatase implicated in a wide variety of regulatory cellular functions. PP2A is abundant in the mammalian nervous system, and dysregulation of its cellular functions is associated with...

  • Article
  • Open Access
15 Citations
3,230 Views
15 Pages

Electrochemotherapy with Bleomycin Enhances Radiosensitivity of Uveal Melanomas: First In Vitro Results in 3D Cultures of Primary Uveal Melanoma Cell Lines

  • Miltiadis Fiorentzis,
  • Ekaterina A. Sokolenko,
  • Nikolaos E. Bechrakis,
  • Saskia Ting,
  • Kurt W. Schmid,
  • Ali Sak,
  • Martin Stuschke,
  • Berthold Seitz and
  • Utta Berchner-Pfannschmidt

21 June 2021

Electrochemotherapy (ECT) is emerging as a complementary treatment modality for local tumor control in various cancer entities. Irradiation is an established therapeutic option for oncologic patients, which is commonly combined with chemotherapy due...

  • Article
  • Open Access
15 Citations
3,793 Views
17 Pages

The Challenge of Choosing the Best Classification Method in Radiomic Analyses: Recommendations and Applications to Lung Cancer CT Images

  • Federica Corso,
  • Giulia Tini,
  • Giuliana Lo Presti,
  • Noemi Garau,
  • Simone Pietro De Angelis,
  • Federica Bellerba,
  • Lisa Rinaldi,
  • Francesca Botta,
  • Stefania Rizzo and
  • Daniela Origgi
  • + 8 authors

21 June 2021

Radiomics uses high-dimensional sets of imaging features to predict biological characteristics of tumors and clinical outcomes. The choice of the algorithm used to analyze radiomic features and perform predictions has a high impact on the results, th...

  • Article
  • Open Access
3 Citations
2,796 Views
16 Pages

Hematopoietic Stem Cell Transplantation-Associated Neurological Complications and Their Brain MR Imaging Findings in a Pediatric Population

  • Hyewon Shin,
  • Mi-Sun Yum,
  • Min-Jee Kim,
  • Jin Kyung Suh,
  • Ho Joon Im,
  • Hyery Kim,
  • Kyung-Nam Koh and
  • Tae-Sung Ko

21 June 2021

Purpose: To determine the prognostic indicators for hematopoietic stem cell transplantation (HSCT)-associated neurological complications, the clinical characteristics and brain magnetic resonance imaging (MRI) lesions in pediatric HSCT recipients wer...

  • Article
  • Open Access
8 Citations
3,646 Views
15 Pages

B-Helper Neutrophils in Regional Lymph Nodes Correlate with Improved Prognosis in Patients with Head and Neck Cancer

  • Ekaterina Pylaeva,
  • Irem Ozel,
  • Anthony Squire,
  • Ilona Spyra,
  • Charlotte Wallner,
  • Magdalena Korek,
  • Georg Korschunow,
  • Maksim Domnich,
  • Elena Siakaeva and
  • Moritz Goetz
  • + 4 authors

21 June 2021

The role of neutrophils during cancer formation and elimination is diverse. Here, for the first time, we investigate neutrophil helper cells (NBH), their influence on B cell activity in the regional lymph nodes (RLN) of head-and-neck cancer patients...

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Cancers - ISSN 2072-6694