Next Article in Journal
Hot Spot TERT Promoter Mutations Are Rare in Sporadic Pancreatic Neuroendocrine Neoplasms and Associated with Telomere Length and Epigenetic Expression Patterns
Next Article in Special Issue
Prospective Assessment of Systemic MicroRNAs as Markers of Response to Neoadjuvant Chemotherapy in Breast Cancer
Previous Article in Journal
HLA Class I Allele Expression and Clinical Outcome in De Novo Metastatic Prostate Cancer
Previous Article in Special Issue
Circulating Plasma Gelsolin: A Predictor of Favorable Clinical Outcomes in Head and Neck Cancer and Sensitive Biomarker for Early Disease Diagnosis Combined with Soluble Fas Ligand
Review

Exploring the Therapeutic Potential of Membrane Transport Proteins: Focus on Cancer and Chemoresistance

1
Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON KIH 8M5, Canada
2
Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, NS B3H 4R2, Canada
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(6), 1624; https://doi.org/10.3390/cancers12061624
Received: 9 June 2020 / Accepted: 16 June 2020 / Published: 19 June 2020
(This article belongs to the Collection Cancer Biomarkers)
Improving the therapeutic efficacy of conventional anticancer drugs represents the best hope for cancer treatment. However, the shortage of druggable targets and the increasing development of anticancer drug resistance remain significant problems. Recently, membrane transport proteins have emerged as novel therapeutic targets for cancer treatment. These proteins are essential for a plethora of cell functions ranging from cell homeostasis to clinical drug toxicity. Furthermore, their association with carcinogenesis and chemoresistance has opened new vistas for pharmacology-based cancer research. This review provides a comprehensive update of our current knowledge on the functional expression profile of membrane transport proteins in cancer and chemoresistant tumours that may form the basis for new cancer treatment strategies. View Full-Text
Keywords: membrane transporters; pumps; ion channels; cancers; chemoresistance membrane transporters; pumps; ion channels; cancers; chemoresistance
Show Figures

Figure 1

MDPI and ACS Style

Almasi, S.; El Hiani, Y. Exploring the Therapeutic Potential of Membrane Transport Proteins: Focus on Cancer and Chemoresistance. Cancers 2020, 12, 1624. https://doi.org/10.3390/cancers12061624

AMA Style

Almasi S, El Hiani Y. Exploring the Therapeutic Potential of Membrane Transport Proteins: Focus on Cancer and Chemoresistance. Cancers. 2020; 12(6):1624. https://doi.org/10.3390/cancers12061624

Chicago/Turabian Style

Almasi, Shekoufeh, and Yassine El Hiani. 2020. "Exploring the Therapeutic Potential of Membrane Transport Proteins: Focus on Cancer and Chemoresistance" Cancers 12, no. 6: 1624. https://doi.org/10.3390/cancers12061624

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop