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Targeting the Microenvironment in High Grade Serous Ovarian Cancer

1
Department of Obstetrics and Gynecology, Northwestern University, Chicago, IL 60611, USA
2
Robert H. Lurie Comprehensive Cancer Center, Chicago, IL 60611, USA
*
Author to whom correspondence should be addressed.
Cancers 2018, 10(8), 266; https://doi.org/10.3390/cancers10080266
Received: 20 July 2018 / Revised: 3 August 2018 / Accepted: 6 August 2018 / Published: 10 August 2018
(This article belongs to the Special Issue The Tumor Microenvironment of High Grade Serous Ovarian Cancer)
Cancer–stroma interactions play a key role in cancer progression and response to standard chemotherapy. Here, we provide a summary of the mechanisms by which the major cellular components of the ovarian cancer (OC) tumor microenvironment (TME) including cancer-associated fibroblasts (CAFs), myeloid, immune, endothelial, and mesothelial cells potentiate cancer progression. High-grade serous ovarian cancer (HGSOC) is characterized by a pro-inflammatory and angiogenic signature. This profile is correlated with clinical outcomes and can be a target for therapy. Accumulation of malignant ascites in the peritoneal cavity allows for secreted factors to fuel paracrine and autocrine circuits that augment cancer cell proliferation and invasiveness. Adhesion of cancer cells to the mesothelial matrix promotes peritoneal tumor dissemination and represents another attractive target to prevent metastasis. The immunosuppressed tumor milieu of HGSOC is permissive for tumor growth and can be modulated therapeutically. Results of emerging preclinical and clinical trials testing TME-modulating therapeutics for the treatment of OC are highlighted. View Full-Text
Keywords: high-grade serous ovarian cancer; tumor microenvironment; angiogenesis; immune response; metastasis; therapeutic targeting strategies high-grade serous ovarian cancer; tumor microenvironment; angiogenesis; immune response; metastasis; therapeutic targeting strategies
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Nwani, N.G.; Sima, L.E.; Nieves-Neira, W.; Matei, D. Targeting the Microenvironment in High Grade Serous Ovarian Cancer. Cancers 2018, 10, 266.

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