Table of Contents
Cancers, Volume 10, Issue 4 (April 2018)
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Cover Story (view full-size image) Anaplastic large cell lymphoma (ALCL) is a T-cell neoplasm with unique morphology and phenotype, [...] Read more. Anaplastic large cell lymphoma (ALCL) is a T-cell neoplasm with unique morphology and phenotype, which is subdivided into four different entities depending on clinical and molecular features: systemic ALK-positive ALCL, systemic ALK-negative ALCL, primary cutaneous ALCL, and breast implant-associated ALCL. While ALK fusion proteins are the genetic hallmark of ALK-positive ALCL and present a paradigm of a dominant oncogenic driver mutation, the genetic landscape of ALK-negative ALCL has only recently been explored further, deepening our understanding of its clinical behavior and pathogenesis and providing new targets to develop specific therapies. View this paper