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Cancers 2018, 10(4), 122;

The Hippo-YAP Pathway Regulates 3D Organ Formation and Homeostasis

Department of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
Author to whom correspondence should be addressed.
Received: 6 March 2018 / Revised: 4 April 2018 / Accepted: 16 April 2018 / Published: 17 April 2018
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The vertebrate body shape is formed by the specific sizes and shapes of its resident tissues and organs, whose alignments are essential for proper functioning. To maintain tissue and organ shape, and thereby function, it is necessary to remove senescent, transformed, and/or damaged cells, which impair function and can lead to tumorigenesis. However, the molecular mechanisms underlying three-dimensional (3D) organ formation and homeostasis are not fully clear. Yes-associated protein (YAP) is a transcriptional co-activator that is involved in organ size control and tumorigenesis. Recently, we reported that YAP is essential for proper 3D body shape through regulation of cell tension by using a unique medaka fish mutant, hirame (hir). In Madin–Darby canine kidney (MDCK) epithelial cells, active YAP-transformed cells are eliminated apically when surrounded by normal cells. Furthermore, in a mosaic mouse model, active YAP-expressing damaged hepatocytes undergo apoptosis and are eliminated from the liver. Thus, YAP functions in quantitative and quality control in organogenesis. In this review, we describe the various roles of YAP in vertebrates, including in the initiation of liver cancer. View Full-Text
Keywords: YAP; Hippo; organogenesis; homeostasis; cell elimination; hepatocyte YAP; Hippo; organogenesis; homeostasis; cell elimination; hepatocyte

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Ishihara, E.; Nishina, H. The Hippo-YAP Pathway Regulates 3D Organ Formation and Homeostasis. Cancers 2018, 10, 122.

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