The Hippo-YAP Pathway Regulates 3D Organ Formation and Homeostasis
AbstractThe vertebrate body shape is formed by the specific sizes and shapes of its resident tissues and organs, whose alignments are essential for proper functioning. To maintain tissue and organ shape, and thereby function, it is necessary to remove senescent, transformed, and/or damaged cells, which impair function and can lead to tumorigenesis. However, the molecular mechanisms underlying three-dimensional (3D) organ formation and homeostasis are not fully clear. Yes-associated protein (YAP) is a transcriptional co-activator that is involved in organ size control and tumorigenesis. Recently, we reported that YAP is essential for proper 3D body shape through regulation of cell tension by using a unique medaka fish mutant, hirame (hir). In Madin–Darby canine kidney (MDCK) epithelial cells, active YAP-transformed cells are eliminated apically when surrounded by normal cells. Furthermore, in a mosaic mouse model, active YAP-expressing damaged hepatocytes undergo apoptosis and are eliminated from the liver. Thus, YAP functions in quantitative and quality control in organogenesis. In this review, we describe the various roles of YAP in vertebrates, including in the initiation of liver cancer. View Full-Text
Share & Cite This Article
Ishihara, E.; Nishina, H. The Hippo-YAP Pathway Regulates 3D Organ Formation and Homeostasis. Cancers 2018, 10, 122.
Ishihara E, Nishina H. The Hippo-YAP Pathway Regulates 3D Organ Formation and Homeostasis. Cancers. 2018; 10(4):122.Chicago/Turabian Style
Ishihara, Erika; Nishina, Hiroshi. 2018. "The Hippo-YAP Pathway Regulates 3D Organ Formation and Homeostasis." Cancers 10, no. 4: 122.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.