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Toxins, Volume 7, Issue 2

February 2015 - 26 articles

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Articles (26)

  • Article
  • Open Access
64 Citations
11,243 Views
21 Pages

5 February 2015

Human health risks from cyanobacterial blooms are primarily related to cyanotoxins that some cyanobacteria produce. Not all species of cyanobacteria can produce toxins. Those that do often do not produce toxins at levels harmful to human health. Moni...

  • Article
  • Open Access
9 Citations
7,045 Views
15 Pages

5 February 2015

kis-kid, the auxiliary maintenance system of plasmid R1 and copB, the auxiliary copy number control gene of this plasmid, contribute to increase plasmid replication efficiency in cells with lower than average copy number. It is thought that Kis antit...

  • Article
  • Open Access
23 Citations
7,511 Views
16 Pages

The Anti-Cancer Potency and Mechanism of a Novel Tumor-Activated Fused Toxin, DLM

  • Dejun Sun,
  • Miaonan Sun,
  • Wenhe Zhu,
  • Zhiding Wang,
  • Yuefei Li and
  • Jie Ma

4 February 2015

Melittin, which acts as a membrane-disrupting lytic peptide, is not only cytotoxic to tumors, but also vital to normal cells. Melittin had low toxicity when coupled with target peptides. Despite significant research development with the fused toxin,...

  • Article
  • Open Access
108 Citations
11,429 Views
18 Pages

Metabolomics of the Bio-Degradation Process of Aflatoxin B1 by Actinomycetes at an Initial pH of 6.0

  • Manal Eshelli,
  • Linda Harvey,
  • RuAngelie Edrada-Ebel and
  • Brian McNeil

4 February 2015

Contamination of food and feed by Aflatoxin B1 (AFB1) is a cause of serious economic and health problems. Different processes have been used to degrade AFB1. In this study, biological degradation of AFB1 was carried out using three Actinomycete speci...

  • Review
  • Open Access
53 Citations
9,081 Views
11 Pages

Recent Insights into Clostridium perfringens Beta-Toxin

  • Masahiro Nagahama,
  • Sadayuki Ochi,
  • Masataka Oda,
  • Kazuaki Miyamoto,
  • Masaya Takehara and
  • Keiko Kobayashi

3 February 2015

Clostridium perfringens beta-toxin is a key mediator of necrotizing enterocolitis and enterotoxemia. It is a pore-forming toxin (PFT) that exerts cytotoxic effect. Experimental investigation using piglet and rabbit intestinal loop models and a mouse...

  • Article
  • Open Access
16 Citations
6,891 Views
16 Pages

Mutagenesis and Functional Analysis of the Pore-Forming Toxin HALT-1 from Hydra magnipapillata

  • Yvonne Jing Mei Liew,
  • Wai Tuck Soh,
  • William Febry Jiemy and
  • Jung Shan Hwang

3 February 2015

Actinoporins are small 18.5 kDa pore-forming toxins. A family of six actinoporin genes has been identified in the genome of Hydra magnipapillata, and HALT-1 (Hydra actinoporin-like toxin-1) has been shown to have haemolytic activity. In this study,...

  • Article
  • Open Access
13 Citations
6,674 Views
13 Pages

Toxicity of the Anti-ribosomal Lectin Ebulin f in Lungs and Intestines in Elderly Mice

  • Manuel Garrosa,
  • Pilar Jiménez,
  • Jesús Tejero,
  • Patricia Cabrero,
  • Damián Cordoba-Diaz,
  • Emiliano J. Quinto,
  • Manuel J. Gayoso and
  • Tomás Girbés

2 February 2015

All parts of dwarf elder (Sambucus ebulus L.) studied so far contain a ribosome-inactivating protein with lectin activity (ribosome-inactivating lectin; RIL), known as ebulin. Green fruits contain ebulin f, the toxicity of which has been studied in...

  • Article
  • Open Access
17 Citations
9,090 Views
16 Pages

Uptake of Clostridium botulinum C3 Exoenzyme into Intact HT22 and J774A.1 Cells

  • Astrid Rohrbeck,
  • Leonie Von Elsner,
  • Sandra Hagemann and
  • Ingo Just

2 February 2015

The Clostridium botulinum C3 exoenzyme selectively ADP-ribosylates low molecular weight GTP-binding proteins RhoA, B and C. This covalent modification inhibits Rho signaling activity, resulting in distinct actin cytoskeleton changes. Although C3 exoe...

  • Article
  • Open Access
34 Citations
9,011 Views
16 Pages

30 January 2015

Microcystin-LR (MC-LR) has been detected extensively in the aquatic environment and has the potential to disturb the thyroid endocrine system. However, limited information is available on the effects of subacute MC-LR exposure on fish thyroid hormone...

  • Article
  • Open Access
75 Citations
11,479 Views
14 Pages

Human Illnesses and Animal Deaths Associated with Freshwater Harmful Algal Blooms—Kansas

  • Ingrid Trevino-Garrison,
  • Jamie DeMent,
  • Farah S. Ahmed,
  • Patricia Haines-Lieber,
  • Thomas Langer,
  • Henri Ménager,
  • Janet Neff,
  • Deon Van der Merwe and
  • Edward Carney

30 January 2015

Freshwater harmful algal bloom (FHAB) toxins can cause morbidity and mortality in both humans and animals, and the incidence of FHABs in the United States and Kansas has increased. In 2010, the Kansas Department of Health and Environment (KDHE) devel...

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Toxins - ISSN 2072-6651