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Toxins 2015, 7(2), 396-406;

Recent Insights into Clostridium perfringens Beta-Toxin

Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho 770-8514, Tokushima, Japan
Department of Microbiology, Fujita Health University School of Medicine, Toyoake 470-1192, Aichi, Japan
Division of Microbiology and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Gakkocho-dori, Chuo-ku 951-8514, Niigata, Japan
Author to whom correspondence should be addressed.
Academic Editor: Teresa Krakauer
Received: 20 December 2014 / Revised: 15 January 2015 / Accepted: 29 January 2015 / Published: 3 February 2015
(This article belongs to the Special Issue Enterotoxins: Microbial Proteins and Host Cell Dysregulation)
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Clostridium perfringens beta-toxin is a key mediator of necrotizing enterocolitis and enterotoxemia. It is a pore-forming toxin (PFT) that exerts cytotoxic effect. Experimental investigation using piglet and rabbit intestinal loop models and a mouse infection model apparently showed that beta-toxin is the important pathogenic factor of the organisms. The toxin caused the swelling and disruption of HL-60 cells and formed a functional pore in the lipid raft microdomains of sensitive cells. These findings represent significant progress in the characterization of the toxin with knowledge on its biological features, mechanism of action and structure-function having been accumulated. Our aims here are to review the current progresses in our comprehension of the virulence of C. perfringens type C and the character, biological feature and structure-function of beta-toxin. View Full-Text
Keywords: Clostridium perfringens; beta-toxin; necrotizing enterocolitis; pore-forming toxin Clostridium perfringens; beta-toxin; necrotizing enterocolitis; pore-forming toxin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Nagahama, M.; Ochi, S.; Oda, M.; Miyamoto, K.; Takehara, M.; Kobayashi, K. Recent Insights into Clostridium perfringens Beta-Toxin. Toxins 2015, 7, 396-406.

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