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Toxins, Volume 17, Issue 3

March 2025 - 51 articles

Cover Story: Paralytic shellfish poisoning is a threat to human health caused by the consumption of shellfish contaminated with toxins of the saxitoxin class. To protect human health, the toxicity of the compounds must be known, and an appropriate method must be used for screening shellfish prior to sale. This review details methods used in biotoxin research highlighting the strengths and weaknesses of each approach. The accurate determination of toxin concentrations can be achieved using analytical methods employing toxicity equivalence factors derived from oral animal toxicity data. Although this level of accuracy cannot be achieved using in vitro assays, these methods have great utility for screening purposes. The way that different countries around the world employ the various techniques to assess the risk posed by shellfish products is discussed. View this paper
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Articles (51)

  • Article
  • Open Access
3 Citations
3,747 Views
14 Pages

Snake Venom Makeover: Age-Dependent Variations in Procoagulant Biochemistry of Egyptian Saw-Scaled Viper (Echis pyramidum pyramidum) Venom

  • Alex Barker,
  • Lee Jones,
  • Lachlan A. Bourke,
  • Lorenzo Seneci,
  • Abhinandan Chowdhury,
  • Aude Violette,
  • Rudy Fourmy,
  • Raul Soria,
  • Matt Aldridge and
  • Bryan G. Fry

19 March 2025

Echis species (saw-scaled vipers) are WHO Category 1 medically significant venomous snakes with potent procoagulant venoms, which cause lethal venom-induced consumptive coagulopathy in human victims. Despite clinical presentations of bites varying si...

  • Article
  • Open Access
1 Citations
1,810 Views
12 Pages

Incidence of Dysphagia and Comorbidities in Patients with Cervical Dystonia, Analyzed by Botulinum Neurotoxin Treatment Exposure

  • Richard L. Barbano,
  • Bahman Jabbari,
  • Marjan Sadeghi,
  • Ahunna Ukah,
  • Emma Yue,
  • Kimberly Becker Ifantides,
  • Nuo-Yu Huang and
  • David Swope

19 March 2025

Dysphagia is prevalent in patients with cervical dystonia (CD) and is a potential adverse event in patients treated with botulinum neurotoxin (BoNT) for CD. Real-world studies may provide a better understanding of the incidence and potential risk fac...

  • Article
  • Open Access
1 Citations
3,852 Views
9 Pages

The Effect of Micro-Focused Ultrasound Treatment on Intradermal Botulinum Toxin Type A Injection

  • Sarawin Harnchoowong,
  • Natthachat Jurairattanaporn and
  • Vasanop Vachiramon

19 March 2025

Botulinum toxin type A (BoNT-A) injection and micro-focused ultrasound with visualization (MFU-V) are becoming increasingly popular for various esthetic conditions. However, performing MFU-V subsequently to BoNT-A injection may diminish the efficacy...

  • Article
  • Open Access
1 Citations
1,842 Views
22 Pages

19 March 2025

The aim of the present study was to evaluate the efficacy of a multicomponent mycotoxin detoxifying agent (MMDA, MYCORAID, Patent Co, Mišićevo, Serbia) in weaned pigs receiving contaminated feed with deoxynivalenol (DON) and zearalenone (...

  • Article
  • Open Access
1,315 Views
15 Pages

Nafamostat Mesylate Regulates Glycosylation to Alleviate Aristolochic Acid Induced Kidney Injury

  • Pei Xie,
  • Huijun Liu,
  • Xingli Huo,
  • Junlong Chen,
  • Yu Li,
  • Yu Huang and
  • Zongning Yin

18 March 2025

Acute kidney injury (AKI) is a condition with a poor prognosis, exacerbated by the lack of effective therapeutic options and inadequately understood underlying mechanisms. Glycosylation, a post-translational modification of proteins, is essential for...

  • Article
  • Open Access
1,081 Views
22 Pages

Ablation of Gut Microbiota Alleviates DON-Induced Neurobehavioral Abnormalities and Brain Damage in Mice

  • Yujing Cui,
  • Samuel Kumi Okyere,
  • Haoyue Guan,
  • Zixuan Hua,
  • Youtian Deng,
  • Huidan Deng and
  • Junliang Deng

18 March 2025

Background: Deoxynivalenol (DON) poses a threat to animal and human health, particularly causing damage to the nervous system. Intestinal flora can regulate the nervous system through the gut–brain axis; however, there is currently a lack of ev...

  • Article
  • Open Access
3 Citations
1,663 Views
25 Pages

17 March 2025

Mycotoxins are toxic compounds found in food and feed that pose significant risks to human and animal health. This work reviews recent studies on the cytotoxic effects of four mycotoxins: beauvericin (BEA), citrinin (CTN), moniliformin (MON), and pat...

  • Article
  • Open Access
2 Citations
1,343 Views
25 Pages

Selective Modulation of Osteoclast Function by Bothrops moojeni Venom and Its Fractions: Implications for Therapeutic Targeting in Bone Diseases

  • Fernanda D’Amélio,
  • Hugo Vigerelli,
  • Isabel de Fátima Correia Batista,
  • Rodrigo Pinheiro Araldi,
  • Álvaro R. B. Prieto-da-Silva,
  • Daniel Carvalho Pimenta and
  • Irina Kerkis

15 March 2025

Our study explores the differential effects of Bothrops moojeni venom and its fractions on osteoclast (OC) morphology, function, and osteoclastogenesis. The crude venom and its high-molecular-weight (HMW) fraction disrupt critical OC processes, inclu...

  • Article
  • Open Access
2 Citations
1,644 Views
15 Pages

15 March 2025

Introduction: Patients with cerebral palsy (CP) present mobility limitations that alter their activity and participation in social life. This study aimed to assess changes in gait kinematic measurements using the Observational Gait Scale (OGS) and pr...

  • Article
  • Open Access
1 Citations
2,289 Views
16 Pages

Botulinum Toxin Type A Exerts Direct Trans-Synaptic Action at Bilateral Spinal Nociceptive Circuits

  • Dalia Nemanić,
  • Petra Šoštarić,
  • Patrik Meglić,
  • Ivica Matak and
  • Lidija Bach-Rojecky

14 March 2025

Botulinum toxin type A (BoNT-A) induces a bilateral analgesic effect following unilateral injection in rodent bilateral or mirror pain models. This occurs either by indirect plasticity-related actions, or by the toxin’s direct central action in...

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Toxins - ISSN 2072-6651