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Toxins 2018, 10(6), 252; https://doi.org/10.3390/toxins10060252

Staphylococcus aureus Toxins and Their Molecular Activity in Infectious Diseases

LEPABE, Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal
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Received: 30 April 2018 / Revised: 14 June 2018 / Accepted: 15 June 2018 / Published: 19 June 2018
(This article belongs to the Collection Staphylococcus aureus Toxins)
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Abstract

Staphylococcus aureus is a microorganism resident in the skin and nasal membranes with a dreadful pathogenic potential to cause a variety of community and hospital-acquired infections. The frequency of these infections is increasing and their treatment is becoming more difficult. The ability of S. aureus to form biofilms and the emergence of multidrug-resistant strains are the main reasons determining the challenge in dealing with these infections. S. aureus' infectious capacity and its success as a pathogen is related to the expression of virulence factors, among which the production of a wide variety of toxins is highlighted. For this reason, a better understanding of S. aureus toxins is needed to enable the development of new strategies to reduce their production and consequently improve therapeutic approaches. This review focuses on understanding the toxin-based pathogenesis of S. aureus and their role on infectious diseases. View Full-Text
Keywords: biofilms; epidemiology; exfoliative toxins; pore-forming toxins; Staphylococcus aureus; superantigens biofilms; epidemiology; exfoliative toxins; pore-forming toxins; Staphylococcus aureus; superantigens
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Oliveira, D.; Borges, A.; Simões, M. Staphylococcus aureus Toxins and Their Molecular Activity in Infectious Diseases. Toxins 2018, 10, 252.

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