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Nutrients, Volume 17, Issue 8

April-2 2025 - 108 articles

Cover Story: In recent years, autoimmune diseases are becoming more and more prevalent worldwide, with this rapid rise being influenced by environmental factors linked to lifestyle changes in modern societies. In this context, the role of diet has been the topic of extensive research as evidence has mounted that particular dietary patterns may contribute to or modulate autoimmunity. The present review specifically focuses on the Mediterranean diet (MD) as a whole dietary pattern, and on its peculiar components, such as n-3 polyunsaturated fatty acids (PUFAs), polyphenols and fiber. We explored their potential benefits in a spectrum of both systemic and organ-specific autoimmune disorders, including rheumatic diseases (like rheumatic arthritis and systemic lupus erythematosus), and thyroid diseases (like Hashimoto’s thyroiditis), since they often occur in the same individuals. View this paper
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Articles (108)

  • Article
  • Open Access
1 Citations
1,527 Views
18 Pages

Multiomics Analysis of a Micronutrient-Rich Dietary Pattern and the Aging Genotype 9p21 on the Plasma Proteome of Young Adults

  • Sara Mahdavi,
  • Katie Rosychuk,
  • David J. A. Jenkins,
  • Andrew J. Percy,
  • Christoph H. Borchers and
  • Ahmed El-Sohemy

21 April 2025

Background: Diet is one of the most significant modifiable lifestyle factors influencing human health, contributing to both morbidity and mortality. Genetic variations in the pleiotropic 9p21 risk locus further shape premature aging, disease suscepti...

  • Article
  • Open Access
1 Citations
1,589 Views
18 Pages

21 April 2025

Background: Breast milk confers essential passive immunity to infants, particularly during viral pandemics. This study investigates dynamic changes in SARS-CoV-2-specific antibodies and proteome in the breast milk of mothers infected with either the...

  • Article
  • Open Access
4 Citations
3,261 Views
15 Pages

The Relationship between Visceral Fat Accumulation and Risk of Cardiometabolic Multimorbidity: The Roles of Accelerated Biological Aging

  • Tianyu Zhu,
  • Yixing Tian,
  • Jinqi Wang,
  • Zhiyuan Wu,
  • Wenhan Xie,
  • Haotian Liu,
  • Xia Li,
  • Lixin Tao and
  • Xiuhua Guo

21 April 2025

Objectives: To investigate the association between visceral fat accumulation and the risk of cardiometabolic multimorbidity (CMM) and the potential roles of accelerated biological aging in this relationship. Methods: Using data from the UK Biobank, a...

  • Review
  • Open Access
2 Citations
1,494 Views
31 Pages

Enhancing Bone Health with Conjugated Linoleic Acid: Mechanisms, Challenges, and Innovative Strategies

  • Khandoker Hoque,
  • Zayana Ali,
  • Asma Maliha,
  • Mohammad A. Al-Ghouti,
  • Chiara Cugno,
  • Shaikh Mizanoor Rahman and
  • Md Mizanur Rahman

21 April 2025

Conjugated linoleic acid (CLA) is a bioactive compound known for its anti-inflammatory, anti-carcinogenic, and metabolic effects, with growing interest in its role in supporting bone health. Preclinical studies, particularly those involving the t10c1...

  • Article
  • Open Access
2 Citations
2,201 Views
20 Pages

Overweight, Obesity, and Depression in Multimorbid Older Adults: Prevalence, Diagnostic Agreement, and Associated Factors in Primary Care—Results from a Multicenter Observational Study

  • Daniel Christopher Bludau,
  • Alexander Pabst,
  • Franziska Bleck,
  • Siegfried Weyerer,
  • Wolfgang Maier,
  • Jochen Gensichen,
  • Karola Mergenthal,
  • Horst Bickel,
  • Angela Fuchs and
  • Ingmar Schäfer
  • + 7 authors

21 April 2025

Background/Objectives: Obesity and depression, in conjunction with multimorbidity, are interconnected conditions increasingly managed in general practitioner (GP) settings, yet these associations remain insufficiently studied in older patients. This...

  • Article
  • Open Access
1 Citations
1,506 Views
13 Pages

A Gut Microbial Metabolite HYA Ameliorates Adipocyte Hypertrophy by Activating AMP-Activated Protein Kinase

  • Rino Matsushita,
  • Kaori Sato,
  • Kunitoshi Uchida,
  • Yukiko Imi,
  • Reina Amano,
  • Nanaho Kasahara,
  • Yuki Kitao,
  • Yuki Oishi,
  • Honoka Kawaai and
  • Chiaki Tomimoto
  • + 4 authors

21 April 2025

Background/Objectives: Metabolites produced by gut microbiota play an important role in the crosstalk between the gut and other organs. Although HYA (10-hydroxy-cis-12-octadecenoic acid), a linoleic acid metabolite produced by lactic acid bacteria re...

  • Article
  • Open Access
1,786 Views
14 Pages

Gut Butyrate Reduction in Blood Pressure Is Associated with Other Vegetables, Whole Fruit, Total Grains, and Sodium Intake

  • Lauren San Diego,
  • Taylor Hogue,
  • Jarrad Hampton-Marcell,
  • Ian M. Carroll,
  • Troy Purdom,
  • Heather Colleran and
  • Marc D. Cook

21 April 2025

Background: African Americans (AA) are disproportionally affected by hypertension (HTN). Gut microbiome metabolites (e.g., butyrate) may mediate the relationship between the microbiome and blood pressure (BP). Previous research reports a consistent i...

  • Article
  • Open Access
1,193 Views
13 Pages

Predicting Weight Loss Success After Gastric Sleeve Surgery: A Machine Learning-Based Approach

  • Mónica Casas Domínguez,
  • Isabel Herrena Montano,
  • Juan José López Gómez,
  • Beatriz Ramos Bachiller,
  • Daniel Antonio de Luis Román and
  • Isabel de la Torre Díez

21 April 2025

Background/Objectives: Obesity is a global health issue, and in this context, bariatric surgery is considered the most effective treatment for severe cases. However, postoperative outcomes vary widely among individuals, driving the development of too...

  • Review
  • Open Access
4 Citations
3,061 Views
25 Pages

21 April 2025

Heat stress (HS), driven by rising global temperatures, significantly impairs the nutritional composition and sensory quality of meat from monogastric animals, particularly swine and poultry. HS induces physiological disturbances, including reduced f...

  • Article
  • Open Access
1 Citations
1,416 Views
15 Pages

Early Nutritional Intervention in Patients with Non-Small Cell Lung Cancer Receiving Concurrent Chemoradiotherapy: A Phase II Prospective Study

  • Fangjie Liu,
  • Qiaoting Luo,
  • Yu Xi,
  • Pengxin Zhang,
  • Yingjia Wu,
  • Suping Guo,
  • Yaoling Dong,
  • Daquan Wang,
  • Qingping Wu and
  • Hui Liu
  • + 2 authors

21 April 2025

Aims: This phase II study aimed to evaluate the impact of early nutritional intervention on the nutritional status and survival of locally advanced non-small cell lung cancer (LANSCLC) patients undergoing concurrent chemoradiotherapy (CCRT). Methods:...

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Nutrients - ISSN 2072-6643Creative Common CC BY license