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The Impact of Nutrigenomics and Personalized Nutrition on Non-infectious Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrigenetics and Nutrigenomics".

Deadline for manuscript submissions: 5 July 2025 | Viewed by 1226

Special Issue Editor


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Guest Editor
Department of Medical and Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, University of Catania, 95123 Catania, Italy
Interests: epidemiology; biostatistics; public health; prevention; chronic diseases; dietary pattern; nutrigenomics; nutriepigenomics
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Special Issue Information

Dear Colleagues,

Nutrigenomics and personalized nutrition have emerged as groundbreaking fields in the study of non-infectious diseases. Understanding how individual genetic makeup interacts with dietary factors to influence health outcomes is of paramount importance in modern medicine. This Special Issue aims to delve into the profound impact of nutrigenomics and personalized nutrition on various non-infectious diseases, shedding light on novel insights and potential preventive and therapeutic interventions.

This Special Issue seeks to explore the intersection of nutrigenomics and personalized nutrition with non-infectious diseases. It aims to provide a platform for researchers to share their findings, advancements and perspectives in this rapidly evolving field. The collection of articles will contribute to enhancing our understanding of the intricate relationship between genetics, diet and disease, ultimately paving the way for personalized approaches to prevention and treatment.

We welcome original research articles and reviews covering a broad spectrum of topics within the realm of nutrigenomics and personalized nutrition, as they relate to non-infectious diseases. The potential themes for submissions include, but are not limited to, the following:

  • Genetic determinants of dietary response;
  • Nutritional epigenetics and disease susceptibility;
  • Biomarkers for personalized dietary recommendations;
  • Role of gut microbiota in personalized nutrition;
  • Implementation of personalized nutrition in clinical practice;
  • Ethical and societal implications of personalized nutrition.

We encourage researchers and scholars from diverse backgrounds to contribute their valuable insights to this Special Issue.

We look forward to receiving your contributions.

Dr. Andrea Maugeri
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrigenomics
  • personalized nutrition
  • non-infectious diseases
  • genetics
  • dietary response
  • epigenetics
  • biomarkers
  • gut microbiota

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Published Papers (1 paper)

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Research

24 pages, 5236 KiB  
Article
Synergistic Effects of Fructose and Food Preservatives on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): From Gut Microbiome Alterations to Hepatic Gene Expression
by Tomas Hrncir, Eva Trckova and Lucia Hrncirova
Nutrients 2024, 16(21), 3722; https://doi.org/10.3390/nu16213722 - 30 Oct 2024
Viewed by 949
Abstract
Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health problem closely linked to dietary habits, particularly high fructose consumption. This study investigates the combined effects of fructose and common food preservatives (sodium benzoate, sodium nitrite, and potassium sorbate) on [...] Read more.
Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health problem closely linked to dietary habits, particularly high fructose consumption. This study investigates the combined effects of fructose and common food preservatives (sodium benzoate, sodium nitrite, and potassium sorbate) on the development and progression of MASLD. Methods: We utilized a human microbiota-associated mouse model, administering 10% fructose with or without preservatives for 11 weeks. Liver histology, hepatic gene expression (microarray analysis), biochemical markers, cytokine profiles, intestinal permeability, and gut microbiome composition (16S rRNA and Internal Transcribed Spacer (ITS) sequencing) were evaluated. Results: Fructose and potassium sorbate synergistically induced liver pathology characterized by increased steatosis, inflammation and fibrosis. These histological changes were associated with elevated liver function markers and altered lipid profiles. The treatments also induced significant changes in both the bacterial and fungal communities and disrupted intestinal barrier function, leading to increased pro-inflammatory responses in the mesenteric lymph nodes. Liver gene expression analysis revealed a wide range of transcriptional changes induced by fructose and modulated by the preservative. Key genes involved in lipid metabolism, oxidative stress, and inflammatory responses were affected. Conclusions: Our findings highlight the complex interactions between dietary components, gut microbiota, and host metabolism in the development of MASLD. The study identifies potential risks associated with the combined consumption of fructose and preservatives, particularly potassium sorbate. Our data reveal new mechanisms that are involved in the development of MASLD and open up a new avenue for the prevention and treatment of MASLD through dietary interventions and the modulation of the microbiome. Full article
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