Vascular Effects of the Polyphenolic Nutraceutical Supplement Taurisolo®: Focus on the Protection of the Endothelial Function

Martelli, Alma; Flori, Lorenzo; Gorica, Era; Piragine, Eugenia; Saviano, Anella; Annunziata, Giuseppe; Di Minno, Matteo Nicola Dario; Ciampaglia, Roberto; Calcaterra, Ilenia; Maione, Francesco; Tenore, Gian Carlo; Novellino, Ettore; Calderone, Vincenzo

doi:10.3390/nu13051540

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Vascular Effects of the Polyphenolic Nutraceutical Supplement Taurisolo^®: Focus on the Protection of the Endothelial Function

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Matteo Nicola Dario Di Minno

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Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy

Interdepartmental Research Center “Nutrafood: Nutraceutica e Alimentazione per la Salute”, University of Pisa, 56126 Pisa, Italy

Interdepartmental Research Center “Biology and Pathology of Ageing”, University of Pisa, 56126 Pisa, Italy

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ImmunoPharmaLab, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy

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Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy

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Department of Translational Medical Sciences, University of Naples Federico II, Via Sergio Pansini 5, 80131 Naples, Italy

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Department of Clinic Medicine and Surgery, University of Naples Federico II, Via Sergio Pansini 5, 80131 Naples, Italy

Author to whom correspondence should be addressed.

Academic Editors: Antonella Di Sotto, Silvia Di Giacomo and Maria Annunziata Carluccio

Nutrients 2021, 13(5), 1540; https://doi.org/10.3390/nu13051540

Received: 23 March 2021 / Revised: 15 April 2021 / Accepted: 29 April 2021 / Published: 2 May 2021

(This article belongs to the Special Issue Plant Polyphenols and Human Health: Novel Findings for Future Therapeutic Developments)

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Abstract

Preservation of vascular endothelium integrity and functionality represents an unmet medical need. Indeed, endothelial dysfunction leads to decreased nitric oxide biosynthesis, which is prodromic of hypertension and hypercoagulability. In this panorama, the nutraceutical supplement Taurisolo^®, a polyphenolic extract from Aglianico cultivar grape, rich in catechin and procyanidins, was evaluated as a vasoprotective, vasorelaxing, anti-hypertensive and anti-coagulant agent in: cell lines, isolated vessels, in vivo models of chronic hypertension and hypercoagulability, and in clinical tests of endothelial reactivity. Taurisolo^® demonstrated to fully protect vascular cell viability from oxidative stimulus at 100 µg/mL and evoke vasorelaxing effects (Emax = 80.6% ± 1.9 and pEC50 = 1.19 ± 0.03) by activation of the Sirtuins-AMPK-pathway. Moreover, Taurisolo^®, chronically administered at 20 mg/Kg/die in in vivo experiments, inhibited the onset of cardiac hypertrophy (heart weight/rat weight = 3.96 ± 0.09 vs. 4.30 ± 0.03), hypercoagulability (decrease of fibrinogen vs. control: p < 0.01) and hypertension (mean of Psys: 200 ± 2 vs. control 234 ± 2 mmHg) and improved endothelial function (Emax = 88.9% ± 1.5 vs. control 59.6% ± 3.6; flow-mediated dilation in healthy volunteers after 400 mg twice daily for 8 weeks vs. baseline: p = 0.019). In conclusion, Taurisolo^® preserves the vascular function against ox-inflamm-ageing process and the consequent cardiovascular accidents. View Full-Text

Keywords: endothelial dysfunction; vascular protection; Taurisolo^®; polyphenolic extract; hypertension; sirtuins; AMPK; nitric oxide; nutraceutical supplement

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MDPI and ACS Style

Martelli, A.; Flori, L.; Gorica, E.; Piragine, E.; Saviano, A.; Annunziata, G.; Di Minno, M.N.D.; Ciampaglia, R.; Calcaterra, I.; Maione, F.; Tenore, G.C.; Novellino, E.; Calderone, V. Vascular Effects of the Polyphenolic Nutraceutical Supplement Taurisolo^®: Focus on the Protection of the Endothelial Function. Nutrients 2021, 13, 1540. https://doi.org/10.3390/nu13051540

AMA Style

Martelli A, Flori L, Gorica E, Piragine E, Saviano A, Annunziata G, Di Minno MND, Ciampaglia R, Calcaterra I, Maione F, Tenore GC, Novellino E, Calderone V. Vascular Effects of the Polyphenolic Nutraceutical Supplement Taurisolo^®: Focus on the Protection of the Endothelial Function. Nutrients. 2021; 13(5):1540. https://doi.org/10.3390/nu13051540

Chicago/Turabian Style

Martelli, Alma, Lorenzo Flori, Era Gorica, Eugenia Piragine, Anella Saviano, Giuseppe Annunziata, Matteo Nicola Dario Di Minno, Roberto Ciampaglia, Ilenia Calcaterra, Francesco Maione, Gian Carlo Tenore, Ettore Novellino, and Vincenzo Calderone. 2021. "Vascular Effects of the Polyphenolic Nutraceutical Supplement Taurisolo^®: Focus on the Protection of the Endothelial Function" Nutrients 13, no. 5: 1540. https://doi.org/10.3390/nu13051540

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