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Article

Probiotic NVP-1703 Alleviates Allergic Rhinitis by Inducing IL-10 Expression: A Four-week Clinical Trial

1
Department of Allergy and Clinical Immunology, Chungbuk National University Hospital, Cheongju 28644, Korea
2
Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju 28644, Korea
3
PB Business Department, Navipharm Inc., Suwon 16209, Korea
4
Department of Internal Medicine, Division of Allergy and Clinical Immunology, Seoul National University Hospital, Seoul 03080, Korea
5
Department of Otorhinolaryngology—Head and Neck Surgery, Hallym University Dongtan Sacred Heart Hospital, Hwaseong 18450, Korea
6
Allergy and Clinical Immunology Research Center, Hallym University College of Medicine, Chuncheon 24252, Korea
7
Neurobiota Research Center, College of Pharmacy, Kyung Hee University, Seoul 02453, Korea
8
Department of Pulmonology and Allergy, Hallym University Dongtan Sacred Heart Hospital, Hwaseong 18450, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work as first authors.
Nutrients 2020, 12(5), 1427; https://doi.org/10.3390/nu12051427
Received: 27 April 2020 / Revised: 11 May 2020 / Accepted: 12 May 2020 / Published: 15 May 2020
Although several recent studies reported that probiotics might be beneficial for allergic rhinitis (AR), the effect of probiotics on AR is not consistent and have not been reproduced between studies. We aimed to determine the efficacy and safety of probiotic NVP-1703, a mixture of Bifidobacterium longum and Lactobacillus plantarum, in subjects with perennial AR. Adult subjects with perennial AR received either NVP-1703 (n = 47) or placebo (n = 48) for four weeks. Total nasal symptom scores (TNSS), rhinitis control assessment test (RCAT), blood eosinophil count, allergen-specific IgE, and immunological parameters in serum and urine were compared at baseline and after four weeks. TNSS changes from baseline at weeks 1, 3, and 4 were significant between the NVP-1703 and placebo groups (p = 0.033, 0.031, and 0.029, respectively). RCAT score showed significant differences between the NVP-1703 and placebo groups (p = 0.049) at week 4. Dermatophagoides farinae-specific IgE levels and serum IL-10 levels were significantly different between the NVP-1703 and placebo groups (p = 0.033 and p = 0.047, respectively). IL-10/IL-4 and IL-10/IL-13 ratios were different between the NVP-1703 and placebo groups at week 4 (p = 0.046 and 0.018, respectively). NVP-1703 treatment reduced urinary prostaglandin F and leukotriene E4 levels (p > 0.05). Therefore, NVP-1703 can be treatment option for perennial AR. View Full-Text
Keywords: allergic rhinitis; probiotics; immunoglobulin E; interleukin-10 allergic rhinitis; probiotics; immunoglobulin E; interleukin-10
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MDPI and ACS Style

Kang, M.-G.; Han, S.-W.; Kang, H.-R.; Hong, S.-J.; Kim, D.-H.; Choi, J.-H. Probiotic NVP-1703 Alleviates Allergic Rhinitis by Inducing IL-10 Expression: A Four-week Clinical Trial. Nutrients 2020, 12, 1427. https://doi.org/10.3390/nu12051427

AMA Style

Kang M-G, Han S-W, Kang H-R, Hong S-J, Kim D-H, Choi J-H. Probiotic NVP-1703 Alleviates Allergic Rhinitis by Inducing IL-10 Expression: A Four-week Clinical Trial. Nutrients. 2020; 12(5):1427. https://doi.org/10.3390/nu12051427

Chicago/Turabian Style

Kang, Min-Gyu, Seung-Won Han, Hye-Ryun Kang, Seok-Jin Hong, Dong-Hyun Kim, and Jeong-Hee Choi. 2020. "Probiotic NVP-1703 Alleviates Allergic Rhinitis by Inducing IL-10 Expression: A Four-week Clinical Trial" Nutrients 12, no. 5: 1427. https://doi.org/10.3390/nu12051427

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