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Case Report

Uncommon Presentation of Granulomatosis with Polyangiitis Mimicking Metastatic Lung Cancer

1
Department of Oncology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark
2
Department of Pathology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark
3
Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark
4
Department of Nephrology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark
*
Authors to whom correspondence should be addressed.
Clin. Pract. 2021, 11(2), 293-302; https://doi.org/10.3390/clinpract11020042
Received: 15 April 2021 / Revised: 3 May 2021 / Accepted: 11 May 2021 / Published: 14 May 2021
Diagnosis of anomalous intrathoracic lesions may be challenging and require a multidisciplinary approach. We present a case of granulomatosis with polyangiitis (GPA) clinically and radiologically mimicking metastatic lung cancer with a bilateral pulmonary mass, mediastinal and cervical lymph node involvement, and pleural effusion. Surgical biopsy of the thoracic lesion revealed necrotic granulomatous inflammation, and the final diagnosis was subsequently confirmed by kidney biopsy and biochemical parameters. This case illustrates how comprehensive diagnosis secures timely and relevant treatment. Systemic vasculitis may be one of the key differential diagnoses in patients with multiorgan involvement, especially with pattern-mimicking lung cancer. View Full-Text
Keywords: intrathoracic lesions; granulomatosis with polyangiitis; GPA; vasculitis; lung cancer differential diagnosis intrathoracic lesions; granulomatosis with polyangiitis; GPA; vasculitis; lung cancer differential diagnosis
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MDPI and ACS Style

Urbanska, E.M.; Elversang, J.; Colville-Ebeling, B.; Löfgren, J.O.; Nelveg-Kristensen, K.E.; Szpirt, W.M. Uncommon Presentation of Granulomatosis with Polyangiitis Mimicking Metastatic Lung Cancer. Clin. Pract. 2021, 11, 293-302. https://doi.org/10.3390/clinpract11020042

AMA Style

Urbanska EM, Elversang J, Colville-Ebeling B, Löfgren JO, Nelveg-Kristensen KE, Szpirt WM. Uncommon Presentation of Granulomatosis with Polyangiitis Mimicking Metastatic Lung Cancer. Clinics and Practice. 2021; 11(2):293-302. https://doi.org/10.3390/clinpract11020042

Chicago/Turabian Style

Urbanska, Edyta M.; Elversang, Johanna; Colville-Ebeling, Bonnie; Löfgren, Johan O.; Nelveg-Kristensen, Karl E.; Szpirt, Wladimir M. 2021. "Uncommon Presentation of Granulomatosis with Polyangiitis Mimicking Metastatic Lung Cancer" Clin. Pract. 11, no. 2: 293-302. https://doi.org/10.3390/clinpract11020042

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