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Personalised Prophylaxis in a Child with Haemophilia A and Type 1 Diabetes

Hemophilia Foundation of Salta, Salta 4400, Argentina
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Academic Editors: Maurizio Aricò and Anna Capasso
Clin. Pract. 2021, 11(2), 287-292; https://doi.org/10.3390/clinpract11020041
Received: 4 December 2020 / Revised: 9 April 2021 / Accepted: 13 April 2021 / Published: 8 May 2021
Poor management of either type 1 diabetes or haemophilia A can lead to complications such as organ dysfunction and haemarthropathy. Here, we describe the case of an 8-year-old boy diagnosed with severe haemophilia A shortly after birth. At 2 years old, he was also diagnosed with type 1 diabetes. After six years, the haemophilia treatment was changed from a plasma-derived factor VIII (FVIII) concentrate (octanate®, Octapharma, Lachen, Switzerland) to Nuwiq® (simocotocog alfa, Octapharma, Lachen, Switzerland), a recombinant FVIII (rFVIII) product from a human cell line, which allowed for a personalised treatment schedule that supported good adherence. The dosing regimen could be reduced to two weekly rFVIII infusions. The patient has experienced no spontaneous bleeds since switching to rFVIII and shows no signs of joint damage after over seven years of FVIII prophylaxis. rFVIII was well tolerated, with no treatment-related adverse events observed. This case illustrates the importance of treatment personalisation for young patients and their families managing concomitant diseases. View Full-Text
Keywords: haemophilia A; diabetes; simoctocog alfa; personalised prophylaxis; coagulation factor VIII haemophilia A; diabetes; simoctocog alfa; personalised prophylaxis; coagulation factor VIII
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MDPI and ACS Style

Cruz, M.S.; Santillan, J.; Lesser, J.; Ortiz, J.P.; Forzani, L. Personalised Prophylaxis in a Child with Haemophilia A and Type 1 Diabetes. Clin. Pract. 2021, 11, 287-292. https://doi.org/10.3390/clinpract11020041

AMA Style

Cruz MS, Santillan J, Lesser J, Ortiz JP, Forzani L. Personalised Prophylaxis in a Child with Haemophilia A and Type 1 Diabetes. Clinics and Practice. 2021; 11(2):287-292. https://doi.org/10.3390/clinpract11020041

Chicago/Turabian Style

Cruz, Maria S.; Santillan, Josefina; Lesser, Julieta; Ortiz, Juan P.; Forzani, Laura. 2021. "Personalised Prophylaxis in a Child with Haemophilia A and Type 1 Diabetes" Clin. Pract. 11, no. 2: 287-292. https://doi.org/10.3390/clinpract11020041

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