Next Article in Journal
Assessment of Antimicrobial Activity of Cerumen (Earwax) and Antibiotics against Pathogenic Bacteria Isolated from Ear Pus Samples
Previous Article in Journal
Optimization and Immobilization of Alpha-Amylase from Bacillus subtilis in Calcium Alginate and Calcium Alginate—Cellulosic Residue Beads
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Microbiology Research
Volume 11
Issue 1
10.4081/mr.2020.8356
microbiolres-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Microbiology Research is published by MDPI from Volume 11 Issue 2 (2020). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Extremophilic Actinomycetes Isolated from Soil in Kazakhstan: Classification and Antimicrobial Activities

by
Ainur Zhulamanova
1,2,
Zhanat Koshenov
1,2,3,
Saikal Shamkeeva
1,4,
Zhannur Markhametova
1,
Diyora Abdukhakimova
1,
Lyudmila Trenozhnikova
5 and
Azliyati Azizan
1,*
1
Nazarbayev University School of Medicine (NUSOM), Nur-Sultan, Kazakhstan
2
National Laboratory Astana, (NLA), Nazarbayev University, Nur-Sultan, Kazakhstan
3
Department of Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria
4
Leipzig University, Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Lepzig, Germany
5
Research and Production Center for Microbiology and Virology (RPCMV), Almaty, Kazakhstan
*
Author to whom correspondence should be addressed.
Microbiol. Res. 2020, 11(1), 8356; https://doi.org/10.4081/mr.2020.8356
Submission received: 29 October 2019 / Revised: 29 October 2019 / Accepted: 3 January 2020 / Published: 14 July 2020

Abstract

Extremophilic actinomycetes species are capable of surviving in extreme environment and producing antibiotics. In this study, we hypothesize that extremophiles produce antimicrobial compounds that are potentially novel agent(s) effective against drug resistant pathogens. The goal of this study is to test inhibitory activity of the extracts derived from extremophilic actinomycetes species against the most prevalent drug-resistant bacteria in Kazakhstani hospitals, and preliminarily analyze chemical composition of the active extracts. Actinomycetes species isolated from the soil of Kazakhstan were cultured in modified media mimicking extreme environment the species were isolated from. Antimicrobial compound(s) extracted with organic solvent were tested against conditionally pathogenic and multi-drug resistant pathogens Acinetobacter baumanni and Pseudomonas aeruginosa. Our study generated promising results regarding the potential discovery of novel components effective against drug resistant pathogens. Future studies will focus on further chemical analysis to identify the active component within these extremophilic extracts.
Keywords: extremophiles; antibiotics; natural products; ESKAPE pathogens extremophiles; antibiotics; natural products; ESKAPE pathogens

Share and Cite

MDPI and ACS Style

Zhulamanova, A.; Koshenov, Z.; Shamkeeva, S.; Markhametova, Z.; Abdukhakimova, D.; Trenozhnikova, L.; Azizan, A. Extremophilic Actinomycetes Isolated from Soil in Kazakhstan: Classification and Antimicrobial Activities. Microbiol. Res. 2020, 11, 8356. https://doi.org/10.4081/mr.2020.8356

AMA Style

Zhulamanova A, Koshenov Z, Shamkeeva S, Markhametova Z, Abdukhakimova D, Trenozhnikova L, Azizan A. Extremophilic Actinomycetes Isolated from Soil in Kazakhstan: Classification and Antimicrobial Activities. Microbiology Research. 2020; 11(1):8356. https://doi.org/10.4081/mr.2020.8356

Chicago/Turabian Style

Zhulamanova, Ainur, Zhanat Koshenov, Saikal Shamkeeva, Zhannur Markhametova, Diyora Abdukhakimova, Lyudmila Trenozhnikova, and Azliyati Azizan. 2020. "Extremophilic Actinomycetes Isolated from Soil in Kazakhstan: Classification and Antimicrobial Activities" Microbiology Research 11, no. 1: 8356. https://doi.org/10.4081/mr.2020.8356

APA Style

Zhulamanova, A., Koshenov, Z., Shamkeeva, S., Markhametova, Z., Abdukhakimova, D., Trenozhnikova, L., & Azizan, A. (2020). Extremophilic Actinomycetes Isolated from Soil in Kazakhstan: Classification and Antimicrobial Activities. Microbiology Research, 11(1), 8356. https://doi.org/10.4081/mr.2020.8356

Article Metrics

Back to TopTop