Search Results (41,810)

Rapid urbanization and climate change have intensified the interconnected challenges of surface heating, air pollution, and declining ecosystem functions, with important implications for regional sustainability. Taking Henan Province, China, as the study area, this study selected 2013, 2018, and 2023 as representative years and used land surface temperature (LST), fine particulate matter (PM2.5), ozone (O3), and net primary productivity (NPP) to characterize the thermal environment, air pollution, and carbon sequestration capacity. Pearson correlation analysis, multiple linear regression, and XGBoost-SHAP were integrated to examine bivariate associations, independent linear associations, factor importance, nonlinear responses, and potential threshold characteristics associated with natural, ecological, and anthropogenic factors. The results showed marked spatial differences in the four environmental variables. The multiple linear regression models explained 57.4–69.0% of the variation in LST, 23.8–72.0% in O3, 81.0–84.8% in PM2.5, and 57.4–62.5% in NPP. Natural factors generally showed relatively large and temporally stable standardized coefficients. Precipitation and potential evapotranspiration were positively associated with LST, whereas elevation and precipitation were negatively associated with PM2.5 and O3. NDVI showed an environmentally favorable pattern, being negatively associated with LST, PM2.5, and O3 but positively associated with NPP. Anthropogenic variables generally exhibited smaller and less temporally stable coefficients. The XGBoost models demonstrated good predictive performance, particularly for PM2.5, with R² values of 0.945, 0.920, and 0.905 in 2013, 2018, and 2023, respectively. SHAP analysis identified DEM, PRE, PET, and NDVI as the main contributors to model predictions and revealed nonlinear responses and potential threshold characteristics. These findings indicate that coordinated management of vegetation cover, hydrothermal conditions, and urban development can support heat mitigation, air pollution control, ecosystem productivity, and more sustainable, climate-resilient, and low-carbon development in rapidly urbanizing regions. Full article

Thunderstorm disasters are one of the major meteorological disasters in China, causing significant human casualties and economic losses each year. Traditional loss compensation insurance is confronted with difficulties such as inspection and assessing, causing low claim processing efficiency, while index insurance can effectively overcome these deficiencies by triggering payment through objective indices. This paper is based on satellite remote sensing monitoring data, using a combination of principal component analysis, random forests, and fuzzy mathematical theory to construct a lightning risk index and design a complete index insurance product. Experimental validation based on historical satellite monitoring data has shown that the risk indices constructed in this paper can effectively capture the temporal and spatial variability of lightning activity. Random forest models have a relatively low fitting error of training labels, and the SHAP values reveal a characteristic weight of importance consistent with physical perception. The insurance product has a reasonable distribution of amount and compensation, and premium pricing balances actuarial fairness with market acceptability. The present methodology provides a transportable design path to monitor and transfer the lightning risk using multi-source remote sensing data, with some outreach value in the field of lightning and other natural disasters. Full article

Harmalol is a β-carboline alkaloid exhibiting promising antioxidant properties; however, a comprehensive understanding of its radical scavenging mechanisms in aqueous media across a wide pH range remains limited. In this study, the antioxidant activity of harmalol toward hydroperoxyl radicals was investigated theoretically at the M06-2X/6-311+G(d,p)/PCM(water) level by combining thermodynamic and kinetic analyses over the pH range 2–13. The calculations revealed that the antioxidant behavior of harmalol strongly depends on its protonation state, tautomeric form, and the surrounding pH. Under physiological conditions, the monocationic form predominates, with a smaller contribution from the neutral/zwitterionic I and II species, and radical scavenging proceeds predominantly via proton-coupled electron transfer (PCET)-type hydrogen-transfer reactions involving the monocationic, neutral and zwitterionic I forms as well as radical adduct formation (RAF) mechanism involving zwitterion I. Analysis of SOMO distributions, spin densities, and atomic charges confirmed that the hydrogen transfer reactions for monocationic, neutral and zwitterionic I forms do not follow a classical hydrogen atom transfer (HAT) mechanism. The zwitterion I and neutral forms of harmalol exhibited significantly higher apparent rate constants for the PCET reaction than the monocationic species. Under alkaline conditions, the monoanionic forms exhibit the most favorable thermodynamic parameters toward radical scavenging via formal hydrogen transfer mechanism. Relaxed potential energy surface scans suggest that hydrogen transfer from both monoanionic forms may proceed through a barrierless pathway, while radical adduct formation can also contribute to the antioxidant activity under strongly basic conditions. In addition, monoanion II efficiently participates in single-electron transfer (SET) reactions characterized by very high apparent rate constants. Overall, the results demonstrate that the antioxidant efficiency of harmalol increases with increasing pH and provide detailed insight into the pH-dependent radical scavenging mechanisms of β-carboline derivatives in aqueous environments. Full article

Many species of actinomycete bacteria synthesise glycosylated polyene macrolides that have potential as antifungal drugs. The sugar residues of these compounds have profound effects on potency, toxicity and water-solubility. The medically important antibiotics amphotericin B and nystatin A1 have a single D-mycosamine sugar on C19 of the polyene macrolactone. A few naturally occurring polyenes have a second sugar residue. This may be attached to C35 of 38-membered macrolactones like nystatins or to the equivalent C27 of 30-membered pentaenes like selvamicin. The recently discovered mandimycin has a C35 disaccharide that changes the mode of action, reduces adverse side effects, and delays the emergence of resistance in laboratory cultures of fungal pathogens. Glycosyltransferases that can modify the C27 and C35 positions are of interest to synthetic biologists. The GloSV enzyme is predicted to add a 2,6-dideoxy-D-hexose to C27 of a pentaene in Saccharopolyspora gloriosae. Here we assess GloSV in strains of the amphotericin producer, Streptomyces nodosus. Low levels of new amphotericin analogues modified with D-oliose or D-digitoxose were identified through HR-LCMS. The identification of this glycosyltransferase will assist the development of streptomycete systems for production of non-toxic polyene glycoanalogues. Full article

Prostate cancer remains one of the most biologically heterogeneous malignancies in men and continues to present major therapeutic challenges despite advances in androgen receptor-targeted therapy and molecular stratification. Increasing evidence suggests that prostate cancer progression is influenced not only by tumor-intrinsic genetic alterations but also by complex interactions involving androgen receptor signaling, inflammatory pathways, metabolic reprogramming, oxidative stress, epigenetic remodeling, immune dysregulation, and gut microbiome-associated signaling. Within this evolving systems-level framework, natural products have attracted increasing attention because of their ability to modulate multiple interconnected molecular pathways. This review examines the molecular basis of prostate cancer progression with particular emphasis on crosstalk among androgen receptor signaling, microbiome-associated regulation, epigenetic adaptation, inflammatory signaling, and tumor microenvironment remodeling. The emerging role of the gut microbiome in androgen metabolism, microbial metabolite production, immune regulation, and endocrine resistance is critically discussed, together with current evidence describing the biological effects of selected phytochemicals including curcumin, epigallocatechin-3-gallate, resveratrol, sulforaphane, quercetin, and genistein. These compounds may influence prostate cancer-associated pathways through modulation of inflammatory signaling, oxidative stress, metabolic adaptation, chromatin remodeling, and microbiome dynamics. Major translational limitations including poor bioavailability, pharmacokinetic variability, microbiome heterogeneity, inconsistent clinical evidence, and incomplete mechanistic understanding are additionally discussed. Rather than considering natural products as isolated anticancer agents, this review adopts a systems-level perspective in which dietary bioactive compounds may function as modulators of interconnected regulatory networks relevant to prostate cancer biology and therapeutic responsiveness. Full article

Agriculture plays a fundamental role in ensuring global food security in the context of a growing population; however, it is also responsible for the substantial consumption of natural resources and greenhouse gas emissions. In this context, the adoption of sustainable practices represents a key strategy to improve agri-food supply chains, including the citrus sector. This study applies the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol to conduct a systematic review aimed at assessing the economic value generated by environmental, social, and economic sustainability practices along the citrus supply chain. The analysis focuses in particular on the role of sustainability certifications, examining both their potential benefits and the constraints associated with their adoption for producers and markets. Positioned at the beginning of the supply chain, producers play a pivotal role in the adoption of sustainable practices, whereas consumers, at the end, are instrumental in assigning market value to sustainability attributes through their purchasing decisions. The results highlight that, although consumer interest in ethical and environmentally friendly citrus products is increasing, this demand is often constrained by the lack of clear, standardized, and easily interpretable sustainability indicators. The review also reveals a significant imbalance in the existing literature, with economic assessments predominantly focused on environmental and production-related outcomes, while the economic value generated by social sustainability practices remains largely unexplored. Moreover, the review emphasizes the strategic role of policymakers in fostering sustainable transitions by providing economic incentives and facilitating access to finance, particularly for smallholders. Overall, the findings suggest that sustainability can generate economic value in the citrus supply chain; however, its effectiveness strongly depends on market recognition, certification credibility, supply chain organization, and institutional support. Full article

Background and Aim: While the proliferation of digital health technologies and wearable devices provides nursing professionals with constant access to biometric data, the pathological reliance on these metrics represents an emerging, yet empirically unexamined, digital anxiety framework. This study aims to theoretically define and systematically analyze this theorized phenomenon—termed “Technohypochondria”—within the context of nursing management and clinical practice. Methods: Utilizing Walker and Avant’s eight-stage concept analysis method, a systematic literature search was conducted across PubMed, CINAHL, Scopus, and Web of Science databases. Following strict inclusion and exclusion criteria, a total of 1240 data sources spanning nursing, management, psychology, and informatics literature were analyzed. Results: Three defining attributes of Technohypochondria emerged inductively from the literature: (1) Biometric data obsession, (2) Digital misinterpretation and catastrophizing, and (3) Need for algorithmic feedback. Unlike the general informational search patterns of cyberchondria, these attributes specifically capture a continuous, device-driven feedback loop. Ownership of wearable technology and inadequate digital health literacy were identified as primary antecedents. The analysis revealed significant managerial consequences, including loss of clinical focus, increased risk of medical errors, and weakened professional autonomy. Conclusions: Technohypochondria operationalizes a specific anxiety framework driven by constant biometric monitoring, conceptually diverging from cyberchondria’s focus on online health-information seeking. For nursing managers, addressing the psychological relationship between staff and technology is a strategic necessity for patient safety and workforce productivity. A primary limitation of this study is its theoretical nature; however, this study provides the essential conceptual foundation awaiting future empirical validation and scale development. Full article

In response to the increasing needs for environmentally friendly products, lignocellulosic natural fibers have been of interest as potential replacements for synthetic reinforcement materials in textiles, composites, and related applications. Among these resources, bast fibers derived from plant stems (flax, hemp, nettle, jute, hop), which contain a high cellulose content, have good mechanical properties, low density, and are renewable, are highly promising. Steam explosion has emerged as a green fiber extraction, defibrillation, and surface modification pretreatment technology. Despite the growing number of studies on steam-exploded natural fibers, a comprehensive understanding of the relationships between processing conditions, fiber modifications, mechanisms, and end-use performance remains limited. This review investigates the structural, chemical, and morphological influences of steam explosion on bast fibers. Specifically, it focuses on the mechanism of steam explosion including the solubilization of hemicellulose, partial lignin redistribution or removal, fiber individualization, and cellulose enrichment. The literature indicates that steam explosion can improve fiber separation, fineness, surface morphology, and interfacial adhesion of the composite materials and reduce the use of hazardous chemicals compared with conventional extraction methods. Nonetheless, conflicting results have also been documented, where the same steam explosion conditions can yield distinct fiber characteristics according to biomass type, composition of biomass, moisture concentration, and the amount of processing involved. Excessive treatment severity may lead to fiber shortening, cellulose degradation, and deterioration of fiber quality, particularly for textile applications requiring long fibers. This review highlights current knowledge gaps regarding the optimization of processing conditions, the understanding of steam explosion mechanisms, and the scale-up of the technology for industrial applications. Full article

Neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, and Amyotrophic lateral sclerosis, are distinguished by progressive neuronal dysfunction caused primarily by oxidative stress, mitochondrial impairment, neuroinflammation, and redox imbalance. Growing evidence suggests that indole-derived compounds have significant neuroprotective potential due to their antioxidant, anti-inflammatory, and redox-modulating properties. This review summarizes the structural and biological significance of indole scaffolds, focusing on the mechanisms by which natural, endogenous, microbiota-derived, and synthetic indole compounds protect neuronal networks. Indole-3-carbinol, 3,3′-diindolylmethane, indole-3-propionic acid, and melatonin are major indole derivatives that control important neuroprotective pathways like Nrf2/ARE signaling, mitochondrial bioenergetics, neurotrophic factor expression, apoptotic regulation, and suppression of proinflammatory mediators. These compounds also maintain synaptic plasticity, reduce reactive oxygen species production, and improve neuronal survival in neurodegenerative disease models. Additionally, updated information from translational and clinical research indicates that indole-based compounds may have promising therapeutic applications; however, obstacles like low bioavailability, metabolic instability, and blood–brain barrier penetration continue to be major obstacles to clinical application. Development in nanoparticle delivery systems, microbiome-targeted interventions, and rational structural optimization may improve therapeutic efficacy and translational potential. Overall, indole-derived compounds are a versatile class of redox modulators with potential applications in the prevention and treatment of neurodegenerative diseases via integrated antioxidant and neuroprotective mechanisms. Full article

Starting from the circular aperture diffraction experiment, this paper decomposes the intrinsic interactions underlying wave–particle duality and proposes a specific interaction force: the velocity-perpendicular interaction force. We derive the characterization formula of this force and show that it can induce the phenomenon of circular aperture diffraction of light, with the theoretical results being highly consistent with those calculated by the Huygens–Fresnel principle. The direction of this force is perpendicular to the relative velocity, originating from the coupling effect between the wave nature of light and the particle nature of the circular aperture structure, and it satisfies a modified inverse square law of distance related to the relative velocity. When photons pass through different positions of the circular aperture, the symmetry effect generates a net interaction time. The product of the main component of this force, the net interaction time, and the radius of the circular aperture constitutes a modulation quantity (a ratio of the Planck’s constant), which exerts an on–off modulation effect on the interaction force, thereby inducing the emergence of annular diffraction fringes. This study provides a novel physical interpretation for the circular aperture diffraction of light from the perspective of interaction forces and clarifies the possible existence form of wave–matter interaction forces. This force formula is expected to effectively describe the behavior of microscopic particles, just like the Schrödinger equation, while providing a brand-new perspective on interactions. It holds great application prospects in fields such as single-photon manipulation and quantum precision measurement. Full article

Beyond their established role in lipid digestion, bile acids function as key metabolic and immune signaling molecules. This review synthesizes recent advances in bile acid metabolism within the context of gout and hyperuricemia, proposing a gut–liver–joint crosstalk framework. Dysregulated bile acid metabolism—characterized by a reduced total bile acid pool, decreased hydrophobic secondary bile acids, elevated 12α-hydroxy bile acids, and impaired enterohepatic circulation—has been mechanistically linked to both hepatic urate overproduction via the PPAR-α/xanthine oxidase pathway and monosodium urate crystal-induced NLRP3 inflammasome activation, although human causal evidence remains to be established. The nuclear receptor FXR suppresses NLRP3 at the transcriptional level, while the membrane receptor TGR5 acts post-translationally through Cyclic adenosine monophosphate/Protein Kinase A (cAMP/PKA) and Glucagon-like peptide-1 (GLP-1) signaling. Gut microbiota dysbiosis amplifies these abnormalities through a vicious cycle of reduced bile acid signaling, increased intestinal permeability, and systemic endotoxemia. Based on these insights, we summarize five therapeutic strategies: FXR modulators, TGR5 agonists, microbiota-based interventions, natural products, and ursodeoxycholic acid replacement therapy. Future research should prioritize gout-specific preclinical models, clinical trials of TGR5 agonists, standardized microbiota-based therapies, dual-target molecules, and personalized patient stratification based on bile acid profiles. Full article

Natural materials derived from plants have attracted considerable attention as sustainable ingredients for skin-related applications. In this study, we evaluated the antioxidant and skin-related biological activities of a plant-derived peptide preparation obtained from Sesamum indicum L. by enzymatic hydrolysis (Vegan Sesamcoll, SCP). The antioxidant activity of SCP was assessed using ABTS and DPPH radical scavenging assays. SCP inhibited collagenase activity and increased type I collagen production in human dermal fibroblasts. In addition, SCP increased hyaluronan synthase 2 (HAS2) and hyaluronan synthase 3 (HAS3) protein production in human epidermal keratinocytes. These findings indicate that SCP exhibited concentration dependent radical scavenging activity, collagenase inhibitory activity, increased type I collagen production, and enhanced HAS2/HAS3 protein production in vitro in human skin cells. The results suggest that SCP may have potential as a plant-derived cosmetic ingredient for skin-related applications. However, additional studies, including further characterization of the peptide preparation, mechanistic investigations, bioavailability evaluation, and human clinical studies, are required to further validate its biological activities and potential cosmetic applications. Full article

Aflatoxin M1 (AFM1) is of primary importance to the food industry, state inspection authorities and consumers alike due to the carcinogenic nature of this toxin and the respective health risk associated with its presence in dairy products. In the present work, 1197 raw cow milk samples were collected and analyzed for AFM1 in the Republic of Cyprus during a five-year period (2021–2025) using the enzyme-linked immunosorbent assay (ELISA), confirmed by liquid chromatography-mass spectrometry (UPLC-MS/MS). Health exposure assessment and risk characterization were also performed for the Cypriot population (men, women and children) regarding milk consumption through the calculation of Estimated Daily Intake (EDI), Hazard Index (HI) and Margin of Exposure (MoE). Results showed that AFM1 in cow milk varied with season: 7.34 ± 8.59 ng/kg for winter, 6.86 ± 10.00 ng/kg for spring, 6.43 ± 7.44 ng/kg for summer and 5.36 ± 7.11 ng/kg for autumn. Among the analyzed years, 2022 and 2025 showed wider concentration ranges, with several samples presenting elevated AFM1 levels compared to the other years. Of the 1197 milk samples analyzed for AFM1 content, 633 were <LOD, 284 < LOQ, 278 at concentrations of 10–50 ng/kg, and only two samples exceeded the limit set by the EU (50 ng/kg). The average amount of AFM1 exposure EDI ranged between 0.026 ng/kg b.w./day for men and 0.061 ng/kg b.w./day for children. HI was <1, recording values of 0.130 for men, 0.155 for women and 0.305 for children. Finally, MoE recorded values > 10,000 (15,385 for men and 12,903 for women) and 6557 for children, indicating that the amount of AFM1 consumed through milk by children may comprise a considerable risk for this population group and consequently AFM1 contamination of milk demands its regular monitoring and evaluation of the respective risk involved. Full article

This study examines the effect of small ply angle deviations on the structural response of carbon fiber-reinforced polymer laminates representative of structures used in unmanned aerial vehicles (UAVs). A combined experimental and numerical approach was applied, including cantilever bending tests and experimental modal analysis, supported by finite element simulations. Laminates with nominal ply orientations of 0°, 5°, and 10° were manufactured using a manual hand lay-up process to reflect typical production variability. The results show that the numerical model accurately captures the observed trends in both bending deformation and natural frequencies, with discrepancies up to 12.5%. A consistent tendency to slightly overestimate stiffness was observed, leading to lower predicted deflections and higher natural frequencies compared to experimental data. The findings confirm that finite element modeling can reliably detect and predict the structural effects of small fiber misalignment, supporting its use in the assessment and design of lightweight composite structures used in UAV applications. Full article