Coexisting Subdural Hematoma in Cerebral Amyloid Angiopathy: A Case Series
Abstract
1. Introduction
2. Case Series
2.1. Case 1
2.2. Case 2
2.3. Case 3
3. Discussion
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
Aß | Amyloid β protein |
AH | Arterial hypertension |
CAA | Cerebral amyloid angiopathy |
CT | Computed tomography |
ECG | Electrocardiogram |
GCS | Glasgow Coma Scale |
ICH | Intracerebral hematoma |
ICU | Intensive care unit |
NED | Neurological emergency department |
mRS | Modified Rankin Score |
NIHSS | National Institutes of Health Stroke Scale |
SAH | Subarachnoid hemorrhage |
SDH | Subdural hematoma |
TBI | Traumatic brain injury |
References
- Rivier, C.A.; Kamel, H.; Sheth, K.N.; Iadecola, C.; Gupta, A.; de Leon, M.J.; Ross, E.; Falcone, G.J.; Murthy, S.B. Cerebral amyloid angiopathy and risk of isolated nontraumatic subdural hemorrhage. JAMA Neurol. 2024, 81, 163–169. [Google Scholar] [CrossRef] [PubMed]
- Xia, L.; Min, W.; Lu, X.; Wang, C.; Jiang, Z.; Zhang, Y.; Ye, S.; Su, Z.; Zheng, W.; Liu, H.; et al. Subdural hemorrhage from cerebral amyloid angiopathy–related intracerebral hemorrhage: A risk factor for postoperative hemorrhage. World Neurosurg. 2017, 107, 103–114. [Google Scholar] [CrossRef] [PubMed]
- Charidimou, A.; Boulouis, G.; Frosch, M.; Baron, J.C.; Pasi, M.; Albucher, J.F.; Banerjee, G.; Barbato, C.; Bonneville, F.; Brandne, S.; et al. The Boston Criteria Version 2.0 for Cerebral Amyloid Angiopathy: A Multicentre, Retrospective, MRI–neuropathology Diagnostic Accuracy Study. Lancet Neurol. 2022, 21, 714–725. [Google Scholar]
- Bax, F.; Greenberg, S.M. Cerebral amyloid angiopathy and nontraumatic subdural hemorrhage. JAMA Neurol. 2024, 81, 888. [Google Scholar] [CrossRef] [PubMed]
- Patel, P.V.; FitzMaurice, E.; Nandigam, R.N.; Auluck, P.; Viswanathan, A.; Goldstein, J.N.; Rosand, J.; Greenberg, S.M.; Smith, E.E. Association of subdural hematoma with increased mortality in lobar intracerebral hemorrhage. Arch. Neurol. 2009, 66, 79–84. [Google Scholar] [CrossRef] [PubMed]
- Edlmann, E.; Giorgi-Coll, S.; Whitfield, P.C.; Carpenter, K.L.H.; Hutchinson, P.J. Pathophysiology of chronic subdural haematoma: Inflammation, angiogenesis and implications for pharmacotherapy. J. Neuroinflamm. 2017, 14, 108. [Google Scholar] [CrossRef] [PubMed]
- Viguier, A.; Raposo, N.; Patsoura, S.; Calviere, L.; Albucher, J.F.; Ruidavets, J.B.; Chollet, F.; Cognard, C.; Olivot, J.M.; Bonneville, F. Subarachnoid and subdural hemorrhages in lobar intracerebral hemorrhage associated with cerebral amyloid angiopathy. Stroke 2019, 50, 1567–1569. [Google Scholar] [CrossRef] [PubMed]
- Bruce, S.S.; Murthy, S.B.; Parikh, N.S.; Schweitzer, A.D.; Roytman, M.; Liechty, B.; Cisse, B.; Kirou, K.A.; Navi, B.B. Cerebral amyloid angiopathy-related inflammation presenting as nontraumatic subdural hematoma. Ann. Intern. Med. Clin. Cases 2024, 3, e230989. [Google Scholar] [CrossRef]
- Storti, B.; Gabriel, M.M.; Sennfält, S.; Canavero, I.; Rifino, N.; Gatti, L.; Bersano, A. Rare forms of cerebral amyloid angiopathy: Pathogenesis, biological and clinical features of CAA-RI and IICAA. Front. Neurosci. 2023, 17, 1219025. [Google Scholar] [CrossRef] [PubMed]
- Nelson, P.T.; Pious, N.M.; Jicha, G.A.; Wilcock, D.M.; Fardo, D.W.; Estus, S.; Rebeck, G.W. APOE-ε2 and APOE-ε4 correlate with increased amyloid accumulation in cerebral vasculature. J. Neuropathol. Exp. Neurol. 2013, 72, 708–715. [Google Scholar] [CrossRef] [PubMed]
- Ghiso, J.; Tomidokoro, Y.; Revesz, T.; Frangione, B.; Rostagno, A. Cerebral amyloid angiopathy and Alzheimer’s disease. Hirosaki Igaku Hirosaki Med. J. 2010, 61, S111–S124. [Google Scholar]
- Kaushik, K.; de Kort, A.M.; van Dort, R.; van der Zwet, R.G.J.; Siegerink, B.; Voigt, S.; van Zwet, E.W.; van der Plas, M.C.; Koemans, E.A.; Rasing, I.; et al. Neuropsychiatric symptoms with focus on apathy and irritability in sporadic and hereditary cerebral amyloid angiopathy. Alzheimers Res. Ther. 2024, 16, 74. [Google Scholar] [CrossRef] [PubMed]
- Oblak, J.P.; Jurečič, A.; Writzl, K.; Frol, S. Preceding Head Trauma in Four Cases of Sporadic Cerebral Amyloid Angiopathy—Case Report Series. J. Stroke Cerebrovasc. Dis. 2022, 31, 106260. [Google Scholar] [CrossRef] [PubMed]
- Kirshner, H.S.; Bradshaw, M. The Inflammatory Form of Cerebral Amyloid Angiopathy or “Cerebral Amyloid Angiopathy-Related Inflammation” (CAARI). Curr. Neurol. Neurosci. Rep. 2015, 15, 54. [Google Scholar] [CrossRef] [PubMed]
- Cetin, H.; Akgor, M.C.; Kocer, B.; Ataoglu, E.E.; İnan, M.A. Extensive Cerebral Amyloid Angiopathy-Related Inflammation Caused by Rheumatoid Arthritis with Histopathological Findings. Neurol. India 2025, 73, 374–376. [Google Scholar] [CrossRef] [PubMed]
- Merella, P.; Casu, G.; Chessa, P.; Atzori, E.; Bandino, S.; Deiana, G. When Atrial Fibrillation Meets Cerebral Amyloid Angiopathy: Current Evidence and Strategies. J. Clin. Med. 2023, 12, 7704. [Google Scholar] [CrossRef] [PubMed]
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Zupan, M.; Straus, L.; Velnar, T.; Bošnjak, M.; Jensen-Kondering, U.; Splavski, B.; Frol, S. Coexisting Subdural Hematoma in Cerebral Amyloid Angiopathy: A Case Series. Neurol. Int. 2025, 17, 125. https://doi.org/10.3390/neurolint17080125
Zupan M, Straus L, Velnar T, Bošnjak M, Jensen-Kondering U, Splavski B, Frol S. Coexisting Subdural Hematoma in Cerebral Amyloid Angiopathy: A Case Series. Neurology International. 2025; 17(8):125. https://doi.org/10.3390/neurolint17080125
Chicago/Turabian StyleZupan, Matija, Lara Straus, Tomaž Velnar, Matic Bošnjak, Ulf Jensen-Kondering, Bruno Splavski, and Senta Frol. 2025. "Coexisting Subdural Hematoma in Cerebral Amyloid Angiopathy: A Case Series" Neurology International 17, no. 8: 125. https://doi.org/10.3390/neurolint17080125
APA StyleZupan, M., Straus, L., Velnar, T., Bošnjak, M., Jensen-Kondering, U., Splavski, B., & Frol, S. (2025). Coexisting Subdural Hematoma in Cerebral Amyloid Angiopathy: A Case Series. Neurology International, 17(8), 125. https://doi.org/10.3390/neurolint17080125