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Neurology International, Volume 17, Issue 5

May 2025 - 17 articles

Cover Story: This experimental study investigates the neuroprotective potential of cilostazol, alone and in combination with aspirin, in a model of focal ischemic stroke. Over four weeks of pre-treatment, followed by induced middle cerebral artery occlusion, we evaluated neurological outcomes and serum biomarkers. Co-administration of cilostazol and aspirin significantly reduced biomarker levels and improved neurological responses compared to monotherapy or control groups. These findings suggest a promising therapeutic strategy for stroke prevention. View this paper
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Articles (17)

  • Article
  • Open Access
1 Citations
1,012 Views
10 Pages

Background/Objectives: Chronic pain is a significant global health challenge and is associated with diverse conditions, such as diabetic neuropathic pain and spinal stenosis. Understanding the mechanisms of pain transmission is crucial, for both the...

  • Systematic Review
  • Open Access
3,629 Views
26 Pages

Background: This systematic review assessed the current literature regarding the analgesic treatment of central neuropathic pain (CNP) in central nervous system (CNS) conditions, such as spinal cord injuries, multiple sclerosis, post-stroke disorders...

  • Brief Report
  • Open Access
834 Views
10 Pages

The Second Exteroceptive Suppression Period of the Temporalis Muscle Is Altered in Migraine Patients with Allodynia

  • Eugenia Rota,
  • Paolo Immovilli,
  • Marco Aguggia,
  • Maria Gabriella Saracco,
  • Elisabetta Ghiglione,
  • Antonella Melotti and
  • Nicola Morelli

Background/Objectives: Studying the second exteroceptive suppression period (ES2) of the temporalis muscle may well shed some light on the brainstem neural circuits involved in migraine pathophysiology. It is known that allodynia is related to an inc...

  • Review
  • Open Access
5 Citations
3,642 Views
18 Pages

The Role of Tau in Neuronal Function and Neurodegeneration

  • Gonzalo Emiliano Aranda-Abreu,
  • Fausto Rojas-Durán,
  • María Elena Hernández-Aguilar,
  • Deissy Herrera-Covarrubias,
  • Luis Isauro García-Hernández,
  • María Rebeca Toledo-Cárdenas and
  • Donají Chi-Castañeda

Tau protein plays a pivotal role in maintaining neuronal structure and function through its regulation of microtubule stability and neuronal polarity. Encoded by the MAPT gene, Tau exists in multiple isoforms due to alternative mRNA splicing, with di...

  • Article
  • Open Access
1 Citations
1,219 Views
19 Pages

Cardiac Autonomic Modulation and Cognitive Performance in Community-Dwelling Older Adults: A Preliminary Study

  • Paula Andreatta Maduro,
  • Luiz Alcides Ramires Maduro,
  • Polyana Evangelista Lima,
  • Ana Clara Castro Silva,
  • Rita de Cássia Montenegro da Silva,
  • Alaine Souza Lima Rocha,
  • Maria Jacqueline Silva Ribeiro,
  • Juliana Magalhães Duarte Matoso,
  • Bruno Bavaresco Gambassi and
  • Paulo Adriano Schwingel

Background/Objectives: Cognitive decline has been increasingly linked to cardiac autonomic regulation; however, its specific associations with cognitive domains, such as information processing speed and executive function, remain unclear. This prelim...

  • Case Report
  • Open Access
1,085 Views
18 Pages

Background and Objectives: Neuropathy is a debilitating disorder characterized by peripheral nerve dysfunction and damage to sensory, motor, and autonomic neurons and their axons. While homozygous mutations in DNAJB2/HSJ1 have been linked to early-on...

  • Article
  • Open Access
1,750 Views
20 Pages

Cerebellar Contributions to Hypokinetic Symptoms in an Acute Lesion Parkinsonism Model

  • Cristofer Zarate-Calderon,
  • Gerardo Marín,
  • Iraís Viveros-Martínez,
  • Lizbeth Vásquez-Celaya,
  • Porfirio Carrillo-Castilla,
  • Gonzalo E. Aranda-Abreu,
  • Donaji Chi-Castañeda and
  • Luis I. García

Background: Parkinsonism, characterized by motor symptoms, is typically attributed to basal ganglia dysfunction. Recent evidence suggests that the cerebellum may also influence these symptoms. This study investigated Crus II, the dentate nucleus (DN)...

  • Review
  • Open Access
1 Citations
3,469 Views
23 Pages

Hydrogen sulfide (H2S) is a highly potent toxic gas, and the brain is a primary target organ following acute intoxications. Accidents and misuse of this gas for nefarious purposes, i.e., bioterrorism, are causes for concern regarding acute poisoning....

  • Article
  • Open Access
1,081 Views
9 Pages

The Impact of Concurrent Chronic Heart Failure and Chronic Kidney Dysfunction on Post-Stroke Rehabilitation Outcomes

  • Azadeh Fischer,
  • Nadja Jauert,
  • Martin Schikora,
  • Michael Joebges and
  • Wolfram Doehner

Background/Objectives: The aim of this study was to evaluate the impact of chronic heart failure (CHF), chronic kidney dysfunction (CKD), and the combined CHF-CKD comorbidity on the outcomes of rehabilitation in stroke patients. Methods: A total of 5...

  • Article
  • Open Access
2 Citations
892 Views
11 Pages

Effect of Cilostazol and Aspirin During Hyperacute Stroke Phase in Rats: An Experimental Research Study

  • Christiana Anastasiadou,
  • Anastasios Papapetrou,
  • George Galyfos,
  • Kostas Vekrellis,
  • Patroklos Katafygiotis,
  • Andreas Lazaris,
  • George Geroulakos,
  • Angelos Megalopoulos,
  • Christos Liapis and
  • Nikolaos Kostomitsopoulos
  • + 1 author

Objective: The contralateral hippocampus, a critical region for cognitive function, is often overlooked in everyday clinical practice and stroke research. This study aimed to evaluate the effect of specific antiplatelet agents on the hippocampus (ips...

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Neurol. Int. - ISSN 2035-8377