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Pharmaceutics, Volume 9, Issue 4 (December 2017)
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Cover Story (view full-size image) Nanoparticle technology has permitted the exploration of many new avenues in parenteral and [...] Read more. Nanoparticle technology has permitted the exploration of many new avenues in parenteral and nonparenteral drug delivery, not only intravenous but also oral, topical, ocular, respiratory and mucosal. Mucosal drug delivery with nanoparticles may be facilitated by chitosan nanoparticles by virtue of chitosan’s Ph-dependent solubility, positive charge which aids binding to mucous, and the evolution of improved drug loading methodologies. This has permitted a greatly expanded scope of potential clinical applications for polymeric nanoparticles by the nonparenteral routes of administration. This review discusses not only these applications but also the technical aspects of nanoparticle fabrication. View this paper