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Article

Gastrointestinal Tracking and Gastric Emptying of Coated Capsules in Rats with or without Sedation Using CT imaging

1
Nuclear Medicine Department and Molecular Imaging Group, University Clinical Hospital (CHUS) and Health Research Institute of Santiago de Compostela (IDIS), 15706 A Coruña, Spain
2
Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Santiago de Compostela (USC), Campus Vida, 15782 Santiago de Compostela, Spain
3
Intract Pharma, Royal College St, London NW1 0NH, UK
4
Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK
5
FabRx Ltd., 3 Romney Road, Ashford TN24 0RW, UK
6
Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I + D Farma Group (GI-1645), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
*
Authors to whom correspondence should be addressed.
Pharmaceutics 2020, 12(1), 81; https://doi.org/10.3390/pharmaceutics12010081
Received: 26 December 2019 / Revised: 14 January 2020 / Accepted: 16 January 2020 / Published: 19 January 2020
Following oral administration, gastric emptying is often a rate-limiting step in the absorption of drugs and is dependent on both physiological and pharmaceutical factors. To guide translation into humans, small animal imaging during pre-clinical studies has been increasingly used to localise the gastrointestinal transit of solid dosage forms. In contrast to humans, however, anaesthesia is usually required for effective imaging in animals which may have unintended effects on intestinal physiology. This study evaluated the effect of anaesthesia and capsule size on the gastric emptying rate of coated capsules in rats. Computed tomography (CT) imaging was used to track and locate the capsules through the gastrointestinal tract. Two commercial gelatine mini-capsules (size 9 and 9h) were filled with barium sulphate (contrast agent) and coated using Eudragit L. Under the effect of anaesthesia, none of the capsules emptied from the stomach. In non-anaesthetised rats, most of the size 9 capsules did not empty from the stomach, whereas the majority of the smaller size 9h capsules successfully emptied from the stomach and moved into the intestine. This study demonstrates that even with capsules designed to empty from the stomach in rats, the gastric emptying of such solid oral dosage forms is not guaranteed. In addition, the use of anaesthesia was found to abolish gastric emptying of both capsule sizes. The work herein further highlights the utility of CT imaging for the effective visualisation and location of solid dosage forms in the intestinal tract of rats without the use of anaesthesia. View Full-Text
Keywords: medical imaging; computed tomography; anesthesia; capsule size; gastric emptying; rodents; gastrointestinal tract; oral drug delivery; drug absorption medical imaging; computed tomography; anesthesia; capsule size; gastric emptying; rodents; gastrointestinal tract; oral drug delivery; drug absorption
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MDPI and ACS Style

Gómez-Lado, N.; Seoane-Viaño, I.; Matiz, S.; Madla, C.M.; Yadav, V.; Aguiar, P.; Basit, A.W.; Goyanes, A. Gastrointestinal Tracking and Gastric Emptying of Coated Capsules in Rats with or without Sedation Using CT imaging. Pharmaceutics 2020, 12, 81. https://doi.org/10.3390/pharmaceutics12010081

AMA Style

Gómez-Lado N, Seoane-Viaño I, Matiz S, Madla CM, Yadav V, Aguiar P, Basit AW, Goyanes A. Gastrointestinal Tracking and Gastric Emptying of Coated Capsules in Rats with or without Sedation Using CT imaging. Pharmaceutics. 2020; 12(1):81. https://doi.org/10.3390/pharmaceutics12010081

Chicago/Turabian Style

Gómez-Lado, Noemí, Iria Seoane-Viaño, Silvia Matiz, Christine M. Madla, Vipul Yadav, Pablo Aguiar, Abdul W. Basit, and Alvaro Goyanes. 2020. "Gastrointestinal Tracking and Gastric Emptying of Coated Capsules in Rats with or without Sedation Using CT imaging" Pharmaceutics 12, no. 1: 81. https://doi.org/10.3390/pharmaceutics12010081

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