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Open AccessArticle

Fabrication of Intragastric Floating, Controlled Release 3D Printed Theophylline Tablets Using Hot-Melt Extrusion and Fused Deposition Modeling

1
College of Pharmacy & Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Korea
2
College of Pharmacy, Sahmyook University, Seoul 01795, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Pharmaceutics 2020, 12(1), 77; https://doi.org/10.3390/pharmaceutics12010077
Received: 27 December 2019 / Revised: 13 January 2020 / Accepted: 13 January 2020 / Published: 17 January 2020
(This article belongs to the Special Issue 3D Printing of Pharmaceuticals and Drug Delivery Devices)
This work presents a novel approach for producing gastro-retentive floating tablets (GRFT) by coupling hot-melt extrusion (HME) and fused deposition three-dimensional printing (3DP). Filaments containing theophylline (THEO) within a hydroxypropyl cellulose (HPC) matrix were prepared using HME. 3DP tablets with different infill percentages and shell thickness were developed and evaluated to determine their drug content, floating behavior, dissolution, and physicochemical properties. The dissolution studies revealed a relationship between the infill percentage/shell thickness and the drug release behavior of the 3DP tablets. All the developed GRFTs possessed the ability to float for 10 h and exhibited zero-order release kinetics. The drug release could be described by the Peppas–Sahlin model, as a combination of Fickian diffusion and swelling mechanism. Drug crystallinity was found unaltered throughout the process. 3DP coupled with HME, could be an effective blueprint to produce controlled-release GRFTs, providing the advantage of simplicity and versatility compared to the conventional methods. View Full-Text
Keywords: theophylline; hot-melt extrusion; fused deposition modeling 3D printing; gastro-retentive floating system; dissolution kinetics; controlled release theophylline; hot-melt extrusion; fused deposition modeling 3D printing; gastro-retentive floating system; dissolution kinetics; controlled release
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MDPI and ACS Style

Giri, B.R.; Song, E.S.; Kwon, J.; Lee, J.-H.; Park, J.-B.; Kim, D.W. Fabrication of Intragastric Floating, Controlled Release 3D Printed Theophylline Tablets Using Hot-Melt Extrusion and Fused Deposition Modeling. Pharmaceutics 2020, 12, 77.

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