Antigenic and Pathogenic Characteristics of QX-Type Avian Infectious Bronchitis Virus Strains Isolated in Southwestern China
by
Shuyun Li †, Lijing Du †, Jing Xia, Jiteng Du, Guojin You, Yiping Wen, Xiaobo Huang, Qing Zhao, Xinfeng Han, Qigui Yan, Rui Wu, Min Cui, Sanjie Cao and Yong Huang *
Shuyun Li †, Lijing Du †, Jing Xia, Jiteng Du, Guojin You, Yiping Wen, Xiaobo Huang, Qing Zhao, Xinfeng Han, Qigui Yan, Rui Wu, Min Cui, Sanjie Cao and Yong Huang *
Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Huimin Road 211, Wenjiang, Chengdu, Sichuan 611130, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Viruses 2019, 11(12), 1154; https://doi.org/10.3390/v11121154
Received: 28 November 2019 / Revised: 9 December 2019 / Accepted: 9 December 2019 / Published: 13 December 2019
(This article belongs to the Section Animal Viruses)
The QX-type avian infectious bronchitis virus (IBV) is still a prevalent genotype in Southwestern China. To analyze the antigenicity and pathogenicity characteristics of the dominant genotype strains (QX-type), S1 gene sequence analysis, virus cross-neutralization tests, and pathogenicity test of eight QX-type IBV isolates were conducted. Sequence analysis showed that the nucleotide homology between the eight strains was high, but distantly related to H120 and 4/91 vaccine strains. Cross-neutralization tests showed that all eight strains isolated from 2015 and 2017 belonged to the same serotype, but exhibited antigenic variations over time. The pathogenicity test of the five QX-type IBV isolates showed that only three strains, CK/CH/SC/DYW/16, CK/CH/SC/MS/17, and CK/CH/SC/GH/15, had a high mortality rate with strong respiratory and renal pathogenicity, whereas CK/CH/SC/PZ/17 and CK/CH/SC/DYYJ/17 caused only mild clinical symptoms and tissue lesions. Our results indicate that the prevalent QX-type IBVs displayed antigenic variations and pathogenicity difference. These findings may provide reference for research on the evolution of IBV and vaccine preparation of infectious bronchitis (IB).
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Keywords:
infectious bronchitis virus; IBV; QX; antigenic; pathogenic
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MDPI and ACS Style
Li, S.; Du, L.; Xia, J.; Du, J.; You, G.; Wen, Y.; Huang, X.; Zhao, Q.; Han, X.; Yan, Q.; Wu, R.; Cui, M.; Cao, S.; Huang, Y. Antigenic and Pathogenic Characteristics of QX-Type Avian Infectious Bronchitis Virus Strains Isolated in Southwestern China. Viruses 2019, 11, 1154.
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