Next Article in Journal
Viral Diversity of Microbats within the South West Botanical Province of Western Australia
Next Article in Special Issue
Investigation of the Role of the Spike Protein in Reversing the Virulence of the Highly Virulent Taiwan Porcine Epidemic Diarrhea Virus Pintung 52 Strains and Its Attenuated Counterpart
Previous Article in Journal
Antigenic and Pathogenic Characteristics of QX-Type Avian Infectious Bronchitis Virus Strains Isolated in Southwestern China
Previous Article in Special Issue
Fatty Acids Regulate Porcine Reproductive and Respiratory Syndrome Virus Infection via the AMPK-ACC1 Signaling Pathway
 
Search for Articles:
Title / Keyword
Author / Affiliation
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
Journals
Viruses
Volume 11
Issue 12
10.3390/v11121156
viruses-logo
Submit to this Journal Review for this Journal Edit a Special Issue
► Article Menu

Article Menu

share announcement question_answer thumb_up
...
textsms
...
Article

Pathogenic Characteristics of a Porcine Astrovirus Strain Isolated in China

by
Qingli Fang
†,
Cui Wang
†,
Huan Liu
,
Qingping Wu
,
Siying Liang
,
Minli Cen
,
Qinting Dong
,
Yingyi Wei
,
Ying Chen
,
Kang Ouyang
,
Zuzhang Wei
* and
Weijian Huang
*
College of Animal Science and Technology, Guangxi University, No.100 Daxue Road, Nanning 530004, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Viruses 2019, 11(12), 1156; https://doi.org/10.3390/v11121156
Received: 3 November 2019 / Revised: 6 December 2019 / Accepted: 11 December 2019 / Published: 13 December 2019
(This article belongs to the Special Issue Endemic and Emerging Swine Viruses)
View Full-Text Download PDF
Browse Figures

Abstract

Astroviral infection is considered to be one of the causes of mammalian diarrheal diseases. It has been shown that astrovirus infections cause varying degrees of diarrhea in turkeys and mice. However, the pathogenesis of porcine astrovirus is unknown. In this study, the virulence of a cytopathic porcine astrovirus (PAstV) strain (PAstV1-GX1) isolated from the PK-15 cell line was tested using seven-day-old nursing piglets. The results showed that PAstV1-GX1 infection could cause mild diarrhea, growth retardation, and damage of the villi of the small intestinal mucosa. However, all the above symptoms could be restored within 7 to 10days post inoculation (dpi). To evaluate the innate immunity response of PAstV in vivo, the alteration of inflammatory cytokine expression in piglets infected with PAstV1-GX1 was determined using quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). The mRNA expression levels of the IFNβ and ISG54 were found to be significantly elevated in virus-infected piglets. In contrast, expression of IFNλ was downregulated in piglets infected with PAstV1-GX1. In addition, the mRNA expression of the tight junction protein 1 and 2 and zonula occludin 1, which are associated with the intestinal barrier permeability, were affected after PAstV1 infection. The present study adds to our understanding of the pathogenic mechanism of PAstV and has established an animal model for further study of pig astrovirus infection. View Full-Text
Keywords: porcine astrovirus; pathogenesis; diarrhea; innate immunity porcine astrovirus; pathogenesis; diarrhea; innate immunity
►▼ Show Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Supplementary Material

SciFeed

Share and Cite

MDPI and ACS Style

Fang, Q.; Wang, C.; Liu, H.; Wu, Q.; Liang, S.; Cen, M.; Dong, Q.; Wei, Y.; Chen, Y.; Ouyang, K.; Wei, Z.; Huang, W. Pathogenic Characteristics of a Porcine Astrovirus Strain Isolated in China. Viruses 2019, 11, 1156. https://doi.org/10.3390/v11121156

AMA Style

Fang Q, Wang C, Liu H, Wu Q, Liang S, Cen M, Dong Q, Wei Y, Chen Y, Ouyang K, Wei Z, Huang W. Pathogenic Characteristics of a Porcine Astrovirus Strain Isolated in China. Viruses. 2019; 11(12):1156. https://doi.org/10.3390/v11121156

Chicago/Turabian Style

Fang, Qingli, Cui Wang, Huan Liu, Qingping Wu, Siying Liang, Minli Cen, Qinting Dong, Yingyi Wei, Ying Chen, Kang Ouyang, Zuzhang Wei, and Weijian Huang. 2019. "Pathogenic Characteristics of a Porcine Astrovirus Strain Isolated in China" Viruses 11, no. 12: 1156. https://doi.org/10.3390/v11121156

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Map by Country/Region

1
Back to TopTop