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Viruses, Volume 10, Issue 12

December 2018 - 71 articles

Cover Story: We employed two different approaches to mutate Sulfolobus islandicus rod-shaped virus 2 (SIRV2). The anti-CRISPR (Acr) gene acrID1 was used as a selection marker to knock out genes from an acrID1-null mutant of SIRV2. Moreover, the endogenous CRISPR-Cas systems of its host were repurposed to knock out all the accessory genes. The results are relevant for future functional studies, and such approaches are applicable to other virus–host systems. View Paper here.
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Articles (71)

  • Article
  • Open Access
19 Citations
13,693 Views
11 Pages

SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (Rousettus aegyptiacus)

  • Neeltje Van Doremalen,
  • Alexandra Schäfer,
  • Vineet D. Menachery,
  • Michael Letko,
  • Trenton Bushmaker,
  • Robert J. Fischer,
  • Dania M. Figueroa,
  • Patrick W. Hanley,
  • Greg Saturday and
  • Ralph S. Baric
  • + 1 author

19 December 2018

Severe acute respiratory syndrome (SARS)-like WIV1-coronavirus (CoV) was first isolated from Rhinolophus sinicus bats and can use the human angiotensin converting enzyme 2 (ACE2) receptor. In the current study, we investigate the ability of WIV1-CoV...

  • Article
  • Open Access
18 Citations
5,900 Views
17 Pages

19 December 2018

The recent emergence and rapid geographic expansion of Zika virus (ZIKV) poses a significant challenge for public health. Although historically causing only mild febrile illness, recent ZIKV outbreaks have been associated with more severe neurologica...

  • Review
  • Open Access
206 Citations
17,315 Views
35 Pages

Cervical Cancer Screening Programs in Europe: The Transition Towards HPV Vaccination and Population-Based HPV Testing

  • Andreas C. Chrysostomou,
  • Dora C. Stylianou,
  • Anastasia Constantinidou and
  • Leondios G. Kostrikis

19 December 2018

Cervical cancer is the fourth most frequently occurring cancer in women around the world and can affect them during their reproductive years. Since the development of the Papanicolaou (Pap) test, screening has been essential in identifying cervical c...

  • Article
  • Open Access
27 Citations
6,275 Views
19 Pages

Simultaneous Detection of Beta and Gamma Human Herpesviruses by Multiplex qPCR Reveals Simple Infection and Coinfection Episodes Increasing Risk for Graft Rejection in Solid Organ Transplantation

  • Yessica Sánchez-Ponce,
  • Gustavo Varela-Fascinetto,
  • José Carlos Romo-Vázquez,
  • Briceida López-Martínez,
  • José Luis Sánchez-Huerta,
  • Israel Parra-Ortega,
  • Ezequiel M. Fuentes-Pananá and
  • Abigail Morales-Sánchez

19 December 2018

Herpesviruses are common components of the human microbiome that become clinically relevant when a competent immunosurveillance is compromised, such as in transplantation. Members of the beta and gamma subfamilies are associated with a wide diversity...

  • Article
  • Open Access
6 Citations
7,099 Views
28 Pages

Global Interactomics Connect Nuclear Mitotic Apparatus Protein NUMA1 to Influenza Virus Maturation

  • Md Niaz Rahim,
  • Ludger Klewes,
  • Ali Zahedi-Amiri,
  • Sabine Mai and
  • Kevin M. Coombs

19 December 2018

Influenza A virus (IAV) infections remain a major human health threat. IAV has enormous genetic plasticity and can rapidly escape virus-targeted anti-viral strategies. Thus, there is increasing interest to identify host proteins and processes the vir...

  • Article
  • Open Access
98 Citations
10,330 Views
9 Pages

Engineering RNA Virus Interference via the CRISPR/Cas13 Machinery in Arabidopsis

  • Rashid Aman,
  • Ahmed Mahas,
  • Haroon Butt,
  • Zahir Ali,
  • Fatimah Aljedaani and
  • Magdy Mahfouz

19 December 2018

Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) systems are key immune mechanisms helping prokaryotic species fend off RNA and DNA viruses. CRISPR/Cas9 has broad applications in basic research and biotec...

  • Meeting Report
  • Open Access
4,502 Views
9 Pages

18 December 2018

The Spanish Network of Bacteriophages and Transducer Elements (FAGOMA) was created to answer the need of Spanish scientists working on phages to exchange knowledge and find synergies. Seven years and five meetings later, the network has become a frui...

  • Review
  • Open Access
30 Citations
5,621 Views
13 Pages

18 December 2018

Prion diseases display multiple disease phenotypes characterized by diverse clinical symptoms, different brain regions affected by the disease, distinct cell tropism and diverse PrPSc deposition patterns. The diversity of disease phenotypes within th...

  • Editorial
  • Open Access
23 Citations
6,546 Views
4 Pages

18 December 2018

The One Health concept recognizes that the health of human beings, animals, plants and the environment is interconnected and interdependent. This idea has been shaped over the centuries and has gained momentum and traction as anatomy, physiology, mic...

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Viruses - ISSN 1999-4915