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Open AccessArticle

SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (Rousettus aegyptiacus)

1
Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
2
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
3
Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
*
Author to whom correspondence should be addressed.
Viruses 2018, 10(12), 727; https://doi.org/10.3390/v10120727
Received: 4 December 2018 / Revised: 15 December 2018 / Accepted: 17 December 2018 / Published: 19 December 2018
(This article belongs to the Section Animal Viruses)
Severe acute respiratory syndrome (SARS)-like WIV1-coronavirus (CoV) was first isolated from Rhinolophus sinicus bats and can use the human angiotensin converting enzyme 2 (ACE2) receptor. In the current study, we investigate the ability of WIV1-CoV to infect Rousettus aegyptiacus bats. No clinical signs were observed throughout the experiment. Furthermore, only four oropharyngeal swabs and two respiratory tissues, isolated on day 3 post inoculation, were found positive for viral RNA. Two out of twelve bats showed a modest increase in coronavirus specific antibodies post challenge. In conclusion, WIV1-CoV was unable to cause a robust infection in Rousettus aegyptiacus bats. View Full-Text
Keywords: WIV1-CoV; coronavirus; emerging infectious diseases; animal model WIV1-CoV; coronavirus; emerging infectious diseases; animal model
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MDPI and ACS Style

Van Doremalen, N.; Schäfer, A.; Menachery, V.D.; Letko, M.; Bushmaker, T.; Fischer, R.J.; Figueroa, D.M.; Hanley, P.W.; Saturday, G.; Baric, R.S.; Munster, V.J. SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (Rousettus aegyptiacus). Viruses 2018, 10, 727.

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