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Volume 13
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10.3390/ma13204619
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Article

Heterogeneous Strain Distribution in the Subchondral Bone of Human Osteoarthritic Femoral Heads, Measured with Digital Volume Correlation

by
Melissa K. Ryan
1,2,3,*,
Sara Oliviero
1,2,
Maria Cristiana Costa
1,2,
J. Mark Wilkinson
1 and
Enrico Dall’Ara
1,2
1
Department of Oncology and Metabolism, Mellanby Centre for Bone Research, University of Sheffield, Sheffield S10 2TN, UK
2
INSIGNEO Institute for in silico Medicine, University of Sheffield, Sheffield S10 2TN, UK
3
Medical Device Research Institute, Flinders University, Adelaide 5042, Australia
*
Author to whom correspondence should be addressed.
Materials 2020, 13(20), 4619; https://doi.org/10.3390/ma13204619
Submission received: 30 July 2020 / Revised: 6 October 2020 / Accepted: 12 October 2020 / Published: 16 October 2020
(This article belongs to the Special Issue Digital Image/Volume Correlation of Biological Tissues and Biomaterials)
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Abstract

Osteoarthritis (OA) is a chronic disease, affecting approximately one third of people over the age of 45. Whilst the etiology and pathogenesis of the disease are still not well understood, mechanics play an important role in both the initiation and progression of osteoarthritis. In this study, we demonstrate the application of stepwise compression, combined with microCT imaging and digital volume correlation (DVC) to measure and evaluate full-field strain distributions within osteoarthritic femoral heads under uniaxial compression. A comprehensive analysis showed that the microstructural features inherent in OA bone did not affect the level of uncertainties associated with the applied methods. The results illustrate the localization of strains at the loading surface as well as in areas of low bone volume fraction and subchondral cysts. Trabecular thickness and connectivity density were identified as the only microstructural parameters with any association to the magnitude of local strain measured at apparent yield strain or the volume of bone exceeding yield strain. This work demonstrates a novel approach to evaluating the mechanical properties of the whole human femoral head in case of severe OA.
Keywords: hip osteoarthritis; subchondral bone; microCT digital volume correlation; strain hip osteoarthritis; subchondral bone; microCT digital volume correlation; strain

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MDPI and ACS Style

Ryan, M.K.; Oliviero, S.; Costa, M.C.; Wilkinson, J.M.; Dall’Ara, E. Heterogeneous Strain Distribution in the Subchondral Bone of Human Osteoarthritic Femoral Heads, Measured with Digital Volume Correlation. Materials 2020, 13, 4619. https://doi.org/10.3390/ma13204619

AMA Style

Ryan MK, Oliviero S, Costa MC, Wilkinson JM, Dall’Ara E. Heterogeneous Strain Distribution in the Subchondral Bone of Human Osteoarthritic Femoral Heads, Measured with Digital Volume Correlation. Materials. 2020; 13(20):4619. https://doi.org/10.3390/ma13204619

Chicago/Turabian Style

Ryan, Melissa K., Sara Oliviero, Maria Cristiana Costa, J. Mark Wilkinson, and Enrico Dall’Ara. 2020. "Heterogeneous Strain Distribution in the Subchondral Bone of Human Osteoarthritic Femoral Heads, Measured with Digital Volume Correlation" Materials 13, no. 20: 4619. https://doi.org/10.3390/ma13204619

APA Style

Ryan, M. K., Oliviero, S., Costa, M. C., Wilkinson, J. M., & Dall’Ara, E. (2020). Heterogeneous Strain Distribution in the Subchondral Bone of Human Osteoarthritic Femoral Heads, Measured with Digital Volume Correlation. Materials, 13(20), 4619. https://doi.org/10.3390/ma13204619

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