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Review

Primary Diffuse Large B-Cell Lymphoma of the Urinary Bladder: Update on a Rare Disease and Potential Diagnostic Pitfalls

1
Pathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy
2
Pathology Unit, Policlinico Riuniti, University of Foggia, 71122 Foggia, Italy
3
Surgical Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy
4
Pathology Unit, Azienda Ospedaliera Santa Maria di Terni, University of Perugia, 05100 Terni, Italy
5
Gastroenterology Division, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy
6
Department of Urology and Renal Transplantation, University of Foggia, 71122 Foggia, Italy
7
Hematology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy
8
Haematopathology Division, European Institute of Oncology-IEO IRCCS Milan, 20141 Milan, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Curr. Oncol. 2022, 29(2), 956-968; https://doi.org/10.3390/curroncol29020081
Received: 31 December 2021 / Revised: 5 February 2022 / Accepted: 9 February 2022 / Published: 10 February 2022
(This article belongs to the Special Issue Haematological Neoplasms: Diagnosis and Management)
Diffuse large B-cell lymphoma (DLBCL) represents the most frequent type of non-Hodgkin lymphoma. Globally, DLBCL is an aggressive disease, requiring an accurate diagnosis and prompt treatment. The diagnosis is often made on biopsy samples of a nodal mass, however, approximately 40% of DLBCL cases arise at extranodal sites. The most common extranodal site is the gastrointestinal tract, however any extranodal area may be primarily involved. Primary urinary bladder lymphoma represents only 0.2% of extranodal non-Hodgkin lymphomas, whereas secondary involvement of the urinary bladder by a systemic lymphoma is a more common event. Despite being rare, DLBCL is considered to represent the predominant primary urinary bladder lymphoma. The majority of cases reported in the bladder belong to the DLBCL, NOS group, and there are only rare cases of EBV-positive DLBCL, NOS. In this review, we summarize the current knowledge on DLBCL primarily occurring in the urinary bladder, with the aim of increasing clinician and pathologist awareness on this aggressive lymphoma rarely arising in the urinary bladder. Additionally, we focus on those entities which should be taken into consideration in the differential diagnosis, highlighting potential diagnostic pitfalls. View Full-Text
Keywords: diffuse large B-cell lymphoma; urinary bladder; extranodal; lymphoma diffuse large B-cell lymphoma; urinary bladder; extranodal; lymphoma
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MDPI and ACS Style

Zanelli, M.; Sanguedolce, F.; Zizzo, M.; Palicelli, A.; Pellegrini, D.; Farinacci, S.; Soriano, A.; Froio, E.; Cormio, L.; Carrieri, G.; Cavazza, A.; Merli, F.; Pileri, S.A.; Ascani, S. Primary Diffuse Large B-Cell Lymphoma of the Urinary Bladder: Update on a Rare Disease and Potential Diagnostic Pitfalls. Curr. Oncol. 2022, 29, 956-968. https://doi.org/10.3390/curroncol29020081

AMA Style

Zanelli M, Sanguedolce F, Zizzo M, Palicelli A, Pellegrini D, Farinacci S, Soriano A, Froio E, Cormio L, Carrieri G, Cavazza A, Merli F, Pileri SA, Ascani S. Primary Diffuse Large B-Cell Lymphoma of the Urinary Bladder: Update on a Rare Disease and Potential Diagnostic Pitfalls. Current Oncology. 2022; 29(2):956-968. https://doi.org/10.3390/curroncol29020081

Chicago/Turabian Style

Zanelli, Magda, Francesca Sanguedolce, Maurizio Zizzo, Andrea Palicelli, David Pellegrini, Sabrina Farinacci, Alessandra Soriano, Elisabetta Froio, Luigi Cormio, Giuseppe Carrieri, Alberto Cavazza, Francesco Merli, Stefano A. Pileri, and Stefano Ascani. 2022. "Primary Diffuse Large B-Cell Lymphoma of the Urinary Bladder: Update on a Rare Disease and Potential Diagnostic Pitfalls" Current Oncology 29, no. 2: 956-968. https://doi.org/10.3390/curroncol29020081

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