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  • Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..

Current Oncology, Volume 17, Issue 11

July 2010 - 3 articles

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Articles (3)

  • Review
  • Open Access
59 Citations
854 Views

1 July 2010

The epidermal growth factor receptor (EGFR), a member of the ErbB family of receptor tyrosine kinases, plays an important role in the control of cell growth and differentiation. Disruption of its signaling leads to neoplastic cell proliferation, migr...

  • Article
  • Open Access
60 Citations
1,363 Views
15 Pages

1 July 2010

Two anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (MoAbs) have been approved in Canada for the treatment of metastatic colorectal cancer (mCRC)—cetuximab, a mouse-human chimeric MoAb, and panitumumab, a fully human MoAb. This pap...

  • Article
  • Open Access
45 Citations
1,261 Views
10 Pages

KRAS Mutation Testing in the Treatment of Metastatic Colorectal Cancer with Anti-EGFR Therapies

  • D. Soulières,
  • W. Greer,
  • Anthony M. Magliocco,
  • D. Huntsman,
  • S. Young,
  • M.-S. Tsao and
  • Suzanne Kamel-Reid

1 July 2010

Survival of patients with metastatic CRC (mCRC) has improved steadily over the past several decades, due largely to the development of new combinations of standard chemotherapy, as well as to the introduction of new targeted therapies. Among the avai...

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Curr. Oncol. - ISSN 1718-7729