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Article

Increased Risk of Gastric Cancer in Asbestos-Exposed Workers: A Retrospective Cohort Study Based on Taiwan Cancer Registry 1980–2015

1
Ph.D. Program in Environmental and Occupational Medicine, College of Medicine, Kaohsiung Medical University and National Health Research Institutes, Kaohsiung 807, Taiwan
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Digestive Disease Center, Show-Chwan Memorial Hospital, Changhua 500, Taiwan
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Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
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Department of Environmental and Occupational Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
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Institute of Labor, Occupational Safety and Health, Ministry of Labor, New Taipei City 221, Taiwan
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National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli County 350, Taiwan
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Institute of Health Policy and Management, College of Public Health, National Taiwan University, Taipei 100, Taiwan
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Institute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan University, Taipei 100, Taiwan
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Department of Public Health, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
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Department of Occupational and Environmental Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editors: Dongmug Kang and Eun A Kim
Int. J. Environ. Res. Public Health 2021, 18(14), 7521; https://doi.org/10.3390/ijerph18147521
Received: 29 April 2021 / Revised: 11 July 2021 / Accepted: 13 July 2021 / Published: 15 July 2021
Asbestos has been recognized as a human carcinogen associated with malignant mesothelioma, cancers of lung, larynx, and ovary. However, a putative association between gastric cancer and asbestos exposure remains controversial. In this study, we aimed to explore gastric cancer risk of workers potentially exposed to asbestos in Taiwan. The asbestos occupational cohort was established from 1950 to 2015 based on the Taiwan Labor Insurance Database, and Taiwan Environmental Protection Agency regulatory datasets, followed by the Taiwan Cancer Registry for the period 1980–2015. Standardized incidence ratios (SIRs) for cancer were computed for the whole cohort using reference rates of the general population, and also reference labor population. Compared with the general population, SIR of the asbestos occupational cohort for the gastric cancer increased both in males (1.05, 95% confidence interval (CI): 1.02–1.09) and females (1.10, 95% CI: 1.01–1.18). A total of 123 worksites were identified to have cases of malignant mesothelioma, where increased risk for gastric cancer was found with a relative risk of 1.76 (95% CI: 1.63–1.90). This 35-year retrospective cohort study of asbestos-exposed workers in Taiwan may provide support for an association between occupational exposure to asbestos and gastric cancer. View Full-Text
Keywords: asbestos; gastric cancer; malignant mesothelioma; occupational cancer; standardized incidence ratio asbestos; gastric cancer; malignant mesothelioma; occupational cancer; standardized incidence ratio
MDPI and ACS Style

Fang, Y.-J.; Chuang, H.-Y.; Pan, C.-H.; Chang, Y.-Y.; Cheng, Y.; Lee, L.J.-H.; Wang, J.-D. Increased Risk of Gastric Cancer in Asbestos-Exposed Workers: A Retrospective Cohort Study Based on Taiwan Cancer Registry 1980–2015. Int. J. Environ. Res. Public Health 2021, 18, 7521. https://doi.org/10.3390/ijerph18147521

AMA Style

Fang Y-J, Chuang H-Y, Pan C-H, Chang Y-Y, Cheng Y, Lee LJ-H, Wang J-D. Increased Risk of Gastric Cancer in Asbestos-Exposed Workers: A Retrospective Cohort Study Based on Taiwan Cancer Registry 1980–2015. International Journal of Environmental Research and Public Health. 2021; 18(14):7521. https://doi.org/10.3390/ijerph18147521

Chicago/Turabian Style

Fang, Yi-Jen, Hung-Yi Chuang, Chih-Hong Pan, Yu-Yin Chang, Yawen Cheng, Lukas J.-H. Lee, and Jung-Der Wang. 2021. "Increased Risk of Gastric Cancer in Asbestos-Exposed Workers: A Retrospective Cohort Study Based on Taiwan Cancer Registry 1980–2015" International Journal of Environmental Research and Public Health 18, no. 14: 7521. https://doi.org/10.3390/ijerph18147521

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