Next Article in Journal
In Silico Evaluation of Antifungal Compounds from Marine Sponges against COVID-19-Associated Mucormycosis
Next Article in Special Issue
A Series of New Pyrrole Alkaloids with ALR2 Inhibitory Activities from the Sponge Stylissa massa
Previous Article in Journal / Special Issue
New Sorbicillinoids with Tea Pathogenic Fungus Inhibitory Effect from Marine-Derived Fungus Hypocrea jecorina H8
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Marine Drugs
Volume 20
Issue 3
10.3390/md20030214
marinedrugs-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Communication

Unique Cyclized Thiolopyrrolones from the Marine-Derived Streptomyces sp. BTBU20218885

by
Fuhang Song
1,†,
Jiansen Hu
2,†,
Xinwan Zhang
3,
Wei Xu
3,
Jinpeng Yang
3,
Shaoyong Li
4 and
Xiuli Xu
3,*
1
School of Light Industry, Beijing Technology and Business University, Beijing 100048, China
2
Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
3
School of Ocean Sciences, China University of Geosciences, Beijing 100083, China
4
School of Pharmacy, Tianjin Medical University, Tianjin 300070, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Mar. Drugs 2022, 20(3), 214; https://doi.org/10.3390/md20030214
Submission received: 15 February 2022 / Revised: 16 March 2022 / Accepted: 16 March 2022 / Published: 18 March 2022
(This article belongs to the Special Issue Heterocyclic Compounds from Marine Organisms)
Browse Figures
Versions Notes

Abstract

Two new cyclized thiolopyrrolone derivatives, namely, thiolopyrrolone A (1) and 2,2-dioxidothiolutin (2), together with the kn own compound, thiolutin (3) were identified from a marine-derived Streptomyces sp. BTBU20218885, which was isolated from a mud sample collected from the coastal region of Xiamen, China. Their chemical structures were determined using spectroscopic data, including HRESIMS, 1D and 2D NMR techniques. 1 possessed a unique unsymmetrical sulfur-containing thiolopyrrolone structure. All the compounds were tested for bioactivities against Staphylococcus aureus, Escherichia coli, Bacille Calmette–Guérin (BCG), Mycobacterium tuberculosis, and Candida albicans. 1 displayed antibacterial activities against BCG, M. tuberculosis, and S. aureus with minimum inhibitory concentration (MIC) values of 10, 10, and 100 μg/mL, respectively. Thiolutin (3) showed antibacterial activities against E. coli, BCG, M. tuberculosis, and S. aureus with MIC values of 6.25, 0.3125, 0.625, and 3.125 μg/mL, respectively.
Keywords: marine-derived Streptomyces; thiolopyrrolone; antibacterial; M. tuberculosis marine-derived Streptomyces; thiolopyrrolone; antibacterial; M. tuberculosis

Share and Cite

MDPI and ACS Style

Song, F.; Hu, J.; Zhang, X.; Xu, W.; Yang, J.; Li, S.; Xu, X. Unique Cyclized Thiolopyrrolones from the Marine-Derived Streptomyces sp. BTBU20218885. Mar. Drugs 2022, 20, 214. https://doi.org/10.3390/md20030214

AMA Style

Song F, Hu J, Zhang X, Xu W, Yang J, Li S, Xu X. Unique Cyclized Thiolopyrrolones from the Marine-Derived Streptomyces sp. BTBU20218885. Marine Drugs. 2022; 20(3):214. https://doi.org/10.3390/md20030214

Chicago/Turabian Style

Song, Fuhang, Jiansen Hu, Xinwan Zhang, Wei Xu, Jinpeng Yang, Shaoyong Li, and Xiuli Xu. 2022. "Unique Cyclized Thiolopyrrolones from the Marine-Derived Streptomyces sp. BTBU20218885" Marine Drugs 20, no. 3: 214. https://doi.org/10.3390/md20030214

APA Style

Song, F., Hu, J., Zhang, X., Xu, W., Yang, J., Li, S., & Xu, X. (2022). Unique Cyclized Thiolopyrrolones from the Marine-Derived Streptomyces sp. BTBU20218885. Marine Drugs, 20(3), 214. https://doi.org/10.3390/md20030214

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop