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Current Issues in Molecular Biology, Volume 45, Issue 3

2023 March - 58 articles

Cover Story: Influenza viruses cause highly contagious respiratory infections and seasonal flu epidemics. The emergence of drug-resistant strains highlights groundbreaking for new antiviral therapeutic approaches. In this study, we provide the first biochemical evidence that 18-hydroxyferruginol (1) and 18-oxoferruginol (2) from Torreya nucifera can inhibit influenza virus infection by modulating the PI3K-Akt and ERK signaling pathways. The consequence of these events is the inhibition of viral RNP export from the nucleus and the disruption of influenza virus replication. Our findings suggest that these abietane diterpenoids have potential as novel antiviral candidates for the development of effective influenza therapies. View this paper
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Articles (58)

  • Article
  • Open Access
13 Citations
3,104 Views
15 Pages

Sucrose Transporter StSUT2 Affects Potato Plants Growth, Flowering Time, and Tuber Yield

  • Hui-Ling Gong,
  • Jin-Bao Liu,
  • Clement Igiraneza and
  • Leonce Dusengemungu

Background: Sucrose transporters (SUTs) mediate sucrose phloem loading in source tissue and sucrose unloading into sink tissue in potatoes and higher plants, thus playing a crucial role in plant growth and development. In potatoes, the physiological...

  • Review
  • Open Access
35 Citations
12,326 Views
20 Pages

Origin and Emergence of Microglia in the CNS—An Interesting (Hi)story of an Eccentric Cell

  • Iasonas Dermitzakis,
  • Maria Eleni Manthou,
  • Soultana Meditskou,
  • Marie-Ève Tremblay,
  • Steven Petratos,
  • Lida Zoupi,
  • Marina Boziki,
  • Evangelia Kesidou,
  • Constantina Simeonidou and
  • Paschalis Theotokis

Microglia belong to tissue-resident macrophages of the central nervous system (CNS), representing the primary innate immune cells. This cell type constitutes ~7% of non-neuronal cells in the mammalian brain and has a variety of biological roles integ...

  • Case Report
  • Open Access
1 Citations
2,971 Views
12 Pages

Stroke-Associating Acute Limb Ischemia Due to the Rupture of a Hydatid Cyst

  • Mihaela Lungu,
  • Violeta Diana Oprea,
  • Andrei Lucian Zaharia,
  • Bianca Stan,
  • Laura Rebegea,
  • Dan Iulian Mocanu,
  • Eva Maria Elkan,
  • Elena Niculet and
  • Ana Croitoru

(1) Background: Hydatidosis, or human cystic echinococcosis, is a zoonotic disease. Endemic in some areas, recently it has an increasing incidence in wider regions, determined by population migration. Clinical features depend on the localization and...

  • Article
  • Open Access
3 Citations
4,136 Views
17 Pages

Alteration of Mesenchymal Stem Cells Isolated from Glioblastoma Multiforme under the Influence of Photodynamic Treatment

  • Kalina Tumangelova-Yuzeir,
  • Krassimir Minkin,
  • Ivan Angelov,
  • Ekaterina Ivanova-Todorova,
  • Ekaterina Kurteva,
  • Georgi Vasilev,
  • Jeliazko Arabadjiev,
  • Petar Karazapryanov,
  • Kaloyan Gabrovski and
  • Dobroslav Kyurkchiev
  • + 2 authors

The central hypothesis for the development of glioblastoma multiforme (GBM) postulates that the tumor begins its development by transforming neural stem cells into cancer stem cells (CSC). Recently, it has become clear that another kind of stem cell,...

  • Article
  • Open Access
8 Citations
6,263 Views
19 Pages

The Effect of a Diet Enriched with Jerusalem artichoke, Inulin, and Fluoxetine on Cognitive Functions, Neurogenesis, and the Composition of the Intestinal Microbiota in Mice

  • Aleksandra Szewczyk,
  • Marta Andres-Mach,
  • Mirosław Zagaja,
  • Agnieszka Kaczmarczyk-Ziemba,
  • Maciej Maj and
  • Joanna Szala-Rycaj

The aim of the study was to assess the effect of long-term administration of natural prebiotics: Jerusalem artichoke (topinambur, TPB) and inulin (INU) as well as one of the most popular antidepressants, fluoxetine (FLU), on the proliferation of neur...

  • Brief Report
  • Open Access
1 Citations
2,061 Views
12 Pages

Understanding the three-dimensional (3D) structure of chromatin is invaluable for researching how it functions. One way to gather this information is the chromosome conformation capture (3C) technique and its follow-up technique Hi-C. Here, we presen...

  • Article
  • Open Access
2,628 Views
16 Pages

Nuclear receptor coregulators are the principal regulators of Estrogen Receptor (ER)-mediated transcription. ERβ, an ER subtype first identified in 1996, is associated with poor outcomes in breast cancer (BCa) subtypes, and the coexpression of t...

  • Article
  • Open Access
7 Citations
2,965 Views
12 Pages

The monitoring of antiviral-resistant influenza virus strains is important for public health given the availability and use of neuraminidase inhibitors and other antivirals to treat infected patients. Naturally occurring oseltamivir-resistant seasona...

  • Article
  • Open Access
5 Citations
4,127 Views
16 Pages

Mutant K-Ras in Pancreatic Cancer: An Insight on the Role of Wild-Type N-Ras and K-Ras-Dependent Cell Cycle Regulation

  • Robert Ferguson,
  • Karen Aughton,
  • Anthony Evans,
  • Victoria Shaw,
  • Jane Armstrong,
  • Adam Ware,
  • Laura Bennett,
  • Eithne Costello and
  • William Greenhalf

The development of K-Ras independence may explain the failure of targeted therapy for pancreatic cancer (PC). In this paper, active N as well as K-Ras was shown in all human cell lines tested. In a cell line dependent on mutant K-Ras, it was shown th...

  • Article
  • Open Access
2,953 Views
14 Pages

Effects of Large Extracellular Vesicles from Kidney Cancer Patients on the Growth and Environment of Renal Cell Carcinoma Xenografts in a Mouse Model

  • Matthieu Ferragu,
  • Luisa Vergori,
  • Vincent Le Corre,
  • Sarah Bellal,
  • Maria del Carmen Martinez and
  • Pierre Bigot

Plasma membrane-derived vesicles, also referred to as large extracellular vesicles (lEVs), are implicated in several pathophysiological situations, including cancer. However, to date, no studies have evaluated the effects of lEVs isolated from patien...

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Curr. Issues Mol. Biol. - ISSN 1467-3045