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Special Issue "Molecular Mechanisms in Demyelinating Disorders of the Central Nervous System"
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".
Deadline for manuscript submissions: 30 September 2023 | Viewed by 7685
Special Issue Editor
2. Laboratory of Histology and Embryology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
Interests: neuroscience; multiple sclerosis; experimental autoimmune encephalomyelitis; intrathecal transplantation; stem cell differentiation; immunohistopathology; in situ hybridization; electron microscopy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
A demyelinating disease is a pathological condition of the nervous system that negatively affects the structure and function of the lipid sheath that surround axons, ultimately interfering with the nerve conduction. These lipid sheaths are lamellar membrane extensions of oligodendrocytes (OLs) in the central nervous system (CNS) and the Schwann cells in the peripheral nervous system (PNS). Myelinoclastic and leukodystrophic are the two categories into which demyelinating diseases have historically been divided. A typical, healthy myelin sheath is damaged in the first group as a result of a toxic, chemical, or autoimmune agent while genetic-based aberrant myelin that is degenerated is present in the latter one, better known as dysmyelination.
Among the three main inflammatory-based CNS demyelinating diseases are multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD) and acute disseminated encephalomyelitis (ADEM). MS is the most prevalent one, affecting millions of people worldwide. Since etiology of these diseases is still largely unknown, there’s a need to establish new biomarkers and prioritize the development of experimental research, particularly in the molecular level. I hereby invite authors to submit original research, review articles or commentaries on molecular mechanisms that shed light to therapeutic strategies in demyelinating disorders of the CNS.
Dr. Paschalis Theotokis
Manuscript Submission Information
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- molecular mechanisms
- oligodendrocyte precursor cells
- lipid metabolism
- microglia and macrophages
- experimental autoimmune