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Article

Excessive Folic Acid Mimics Folate Deficiency in Human Lymphocytes

by
Khadijah I. Alnabbat
1,2,
Ali M. Fardous
1,
Diane C. Cabelof
1 and
Ahmad R. Heydari
1,3,*
1
Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48202, USA
2
Department of Food and Nutrition Sciences, King Faisal University, Al Hufūf 31982, Saudi Arabia
3
Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48202, USA
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2022, 44(4), 1452-1462; https://doi.org/10.3390/cimb44040097
Submission received: 22 February 2022 / Revised: 14 March 2022 / Accepted: 20 March 2022 / Published: 23 March 2022
(This article belongs to the Special Issue Involvement of Medicinal Plants and Food in the Molecular Mechanisms of Disease Prevention)
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Abstract

Food fortification with synthetic folic acid (FA), along with supplementation, results in a marked increase in the population total of serum folates and unmetabolized folic acid (UMFA). Despite the success in reducing neural tube defects at birth in the intended target population (women of childbearing age), the potential deleterious effects of chronically high levels of UMFA in susceptible segments of the population require further investigation. In this study, we examine the effects of FA concentrations, ranging from depletion to supraphysiological levels, on markers of proliferation, DNA methylation, and DNA damage and repair in a human lymphoblastoid cell line (LCL). We note that both low and high levels of FA similarly impact global DNA methylation, cytome biomarkers measured through the CBMN assay, DNA damage induced by oxidative stress, and DNA base excision repair gene expression.
Keywords: folate; folic acid; restriction; depletion; excess; supraphysiological; UMFA; LCL; lymphocyte folate; folic acid; restriction; depletion; excess; supraphysiological; UMFA; LCL; lymphocyte

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MDPI and ACS Style

Alnabbat, K.I.; Fardous, A.M.; Cabelof, D.C.; Heydari, A.R. Excessive Folic Acid Mimics Folate Deficiency in Human Lymphocytes. Curr. Issues Mol. Biol. 2022, 44, 1452-1462. https://doi.org/10.3390/cimb44040097

AMA Style

Alnabbat KI, Fardous AM, Cabelof DC, Heydari AR. Excessive Folic Acid Mimics Folate Deficiency in Human Lymphocytes. Current Issues in Molecular Biology. 2022; 44(4):1452-1462. https://doi.org/10.3390/cimb44040097

Chicago/Turabian Style

Alnabbat, Khadijah I., Ali M. Fardous, Diane C. Cabelof, and Ahmad R. Heydari. 2022. "Excessive Folic Acid Mimics Folate Deficiency in Human Lymphocytes" Current Issues in Molecular Biology 44, no. 4: 1452-1462. https://doi.org/10.3390/cimb44040097

APA Style

Alnabbat, K. I., Fardous, A. M., Cabelof, D. C., & Heydari, A. R. (2022). Excessive Folic Acid Mimics Folate Deficiency in Human Lymphocytes. Current Issues in Molecular Biology, 44(4), 1452-1462. https://doi.org/10.3390/cimb44040097

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