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Volume 44
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10.3390/cimb44020049
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Systematic Review

Evidence from a Systematic Review and Meta-Analysis Pointing to the Antidiabetic Effect of Polyphenol-Rich Plant Extracts from Gymnema montanum, Momordica charantia and Moringa oleifera

by
Michal Krawczyk
,
Izabela Burzynska-Pedziwiatr
,
Lucyna Alicja Wozniak
and
Malgorzata Bukowiecka-Matusiak
*
Chair of Medical Biology, Laboratory of Metabolomic Studies, Department of Structural Biology, Faculty of Medicine, Faculty of Biomedical Sciences, Medical University of Lodz, Zeligowskiego 7/9, 90-752 Lodz, Poland
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2022, 44(2), 699-717; https://doi.org/10.3390/cimb44020049
Submission received: 12 January 2022 / Revised: 26 January 2022 / Accepted: 26 January 2022 / Published: 28 January 2022
(This article belongs to the Special Issue Natural Products as Potential Sources of Antidiabetic Compounds)
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Abstract

In vitro and animal model studies are of great interest for selecting new phytochemicals, including polyphenols with antioxidative properties, as candidates for antidiabetic drugs. This review provides evidence from a critical literature data analysis on the effects of plant extract supplementation in diabetes mellitus management. We considered and meta-analyzed the efficacy of oral supplementation of plant extracts in animal model studies and examined physiological and oxidative stress parameters. Finally, 23 articles were included in the meta-analysis, revealing three plants with experimentally confirmed in vivo and in vitro antidiabetic properties: Gymnema montanum, Momordica charantia and Moringa oleifera. The following parameter changes resulted from an investigation of the supplementation: reduced oxidative stress, decreased insulin resistance, increased insulin release, reduced adiposity, and a modulatory effect on glycolysis and gluconeogenesis, as well as attenuation of diabetes-associated weight loss, reduced fasting blood glucose and lowered oxidative status. A comparison of Gymnema montanum versus Glybenclamide revealed the superiority of extracts over drug administration in some aspects. Although the analyzed extracts are promising candidates for antidiabetic treatment, there is much inconsistent data in the literature. Therefore, ultimate references for using these compounds in the prevention of diabetes are currently not applicable.
Keywords: diabetic rats; plant extracts; phytochemicals; supplementation; oxidative stress diabetic rats; plant extracts; phytochemicals; supplementation; oxidative stress

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MDPI and ACS Style

Krawczyk, M.; Burzynska-Pedziwiatr, I.; Wozniak, L.A.; Bukowiecka-Matusiak, M. Evidence from a Systematic Review and Meta-Analysis Pointing to the Antidiabetic Effect of Polyphenol-Rich Plant Extracts from Gymnema montanum, Momordica charantia and Moringa oleifera. Curr. Issues Mol. Biol. 2022, 44, 699-717. https://doi.org/10.3390/cimb44020049

AMA Style

Krawczyk M, Burzynska-Pedziwiatr I, Wozniak LA, Bukowiecka-Matusiak M. Evidence from a Systematic Review and Meta-Analysis Pointing to the Antidiabetic Effect of Polyphenol-Rich Plant Extracts from Gymnema montanum, Momordica charantia and Moringa oleifera. Current Issues in Molecular Biology. 2022; 44(2):699-717. https://doi.org/10.3390/cimb44020049

Chicago/Turabian Style

Krawczyk, Michal, Izabela Burzynska-Pedziwiatr, Lucyna Alicja Wozniak, and Malgorzata Bukowiecka-Matusiak. 2022. "Evidence from a Systematic Review and Meta-Analysis Pointing to the Antidiabetic Effect of Polyphenol-Rich Plant Extracts from Gymnema montanum, Momordica charantia and Moringa oleifera" Current Issues in Molecular Biology 44, no. 2: 699-717. https://doi.org/10.3390/cimb44020049

APA Style

Krawczyk, M., Burzynska-Pedziwiatr, I., Wozniak, L. A., & Bukowiecka-Matusiak, M. (2022). Evidence from a Systematic Review and Meta-Analysis Pointing to the Antidiabetic Effect of Polyphenol-Rich Plant Extracts from Gymnema montanum, Momordica charantia and Moringa oleifera. Current Issues in Molecular Biology, 44(2), 699-717. https://doi.org/10.3390/cimb44020049

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