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Pharmaceuticals
Volume 16
Issue 8
10.3390/ph16081136
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Review

A Review of the Role of Natural Products as Treatment Approaches for Xerostomia

by
Konstantinos N. Kontogiannopoulos
1,*,
Afroditi Kapourani
1,
Ioannis Gkougkourelas
1,
Maria-Emmanouela Anagnostaki
1,
Lazaros Tsalikis
2,
Andreana N. Assimopoulou
3,4 and
Panagiotis Barmpalexis
1,4
1
Department of Pharmaceutical Technology, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
2
Department of Preventive Dentistry, Periodontology and Implant Biology, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
3
Laboratory of Organic Chemistry, School of Chemical Engineering, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
4
Natural Products Research Centre of Excellence-AUTH (NatPro-AUTH), Center for Interdisciplinary Research and Innovation (CIRI-AUTH), 57001 Thessaloniki, Greece
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2023, 16(8), 1136; https://doi.org/10.3390/ph16081136
Submission received: 16 June 2023 / Revised: 8 August 2023 / Accepted: 9 August 2023 / Published: 10 August 2023
(This article belongs to the Section Natural Products)
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Abstract

Xerostomia, commonly known as dry mouth, is a widespread oral health malfunction characterized by decreased salivary flow. This condition results in discomfort, impaired speech and mastication, dysphagia, heightened susceptibility to oral infections, and ultimately, a diminished oral health-related quality of life. The etiology of xerostomia is multifaceted, with primary causes encompassing the use of xerostomic medications, radiation therapy to the head and neck, and systemic diseases such as Sjögren’s syndrome. Consequently, there is a growing interest in devising management strategies to address this oral health issue, which presents significant challenges due to the intricate nature of saliva. Historically, natural products have served medicinal purposes, and in contemporary pharmaceutical research and development, they continue to play a crucial role, including the treatment of xerostomia. In this context, the present review aims to provide an overview of the current state of knowledge regarding natural compounds and extracts for xerostomia treatment, paving the way for developing novel therapeutic strategies for this common oral health issue.
Keywords: xerostomia; dry mouth; natural products; artificial saliva; salivary substitutes xerostomia; dry mouth; natural products; artificial saliva; salivary substitutes

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MDPI and ACS Style

Kontogiannopoulos, K.N.; Kapourani, A.; Gkougkourelas, I.; Anagnostaki, M.-E.; Tsalikis, L.; Assimopoulou, A.N.; Barmpalexis, P. A Review of the Role of Natural Products as Treatment Approaches for Xerostomia. Pharmaceuticals 2023, 16, 1136. https://doi.org/10.3390/ph16081136

AMA Style

Kontogiannopoulos KN, Kapourani A, Gkougkourelas I, Anagnostaki M-E, Tsalikis L, Assimopoulou AN, Barmpalexis P. A Review of the Role of Natural Products as Treatment Approaches for Xerostomia. Pharmaceuticals. 2023; 16(8):1136. https://doi.org/10.3390/ph16081136

Chicago/Turabian Style

Kontogiannopoulos, Konstantinos N., Afroditi Kapourani, Ioannis Gkougkourelas, Maria-Emmanouela Anagnostaki, Lazaros Tsalikis, Andreana N. Assimopoulou, and Panagiotis Barmpalexis. 2023. "A Review of the Role of Natural Products as Treatment Approaches for Xerostomia" Pharmaceuticals 16, no. 8: 1136. https://doi.org/10.3390/ph16081136

APA Style

Kontogiannopoulos, K. N., Kapourani, A., Gkougkourelas, I., Anagnostaki, M.-E., Tsalikis, L., Assimopoulou, A. N., & Barmpalexis, P. (2023). A Review of the Role of Natural Products as Treatment Approaches for Xerostomia. Pharmaceuticals, 16(8), 1136. https://doi.org/10.3390/ph16081136

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